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Volume 24 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2006  >  (2): 83-86

Liu Ye, QI Li-Hong, ZHANG Yue-Fan, Xiao Zhen Yu, ZHANG Min, ZHANG Jun-Ping. Inhibitory effects of six flavonoids on collagen synthesis of rat hepatic stellate cells[J]. Journal of Pharmaceutical Practice and Service, 2006, (2): 83-86.
Citation: Liu Ye, QI Li-Hong, ZHANG Yue-Fan, Xiao Zhen Yu, ZHANG Min, ZHANG Jun-Ping. Inhibitory effects of six flavonoids on collagen synthesis of rat hepatic stellate cells[J]. Journal of Pharmaceutical Practice and Service, 2006, (2): 83-86.
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Inhibitory effects of six flavonoids on collagen synthesis of rat hepatic stellate cells

  • 1.

    Department of Pharmacy, Fuzhou General Hospital, PLA Nanjing Military Area Command, Fuzhou 350001, China

  • 2.

    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2005-09-14
  • Objective : To study the effects of six flavonoids (fisetin, quercetin, apigenin, phloretin, hesperectin, and chalcone)on collagen synthesis of immortallized rat hepatic stellate cell line HSC-T6 cells. Methods : Collagen synthesis was determined by 3H-proline incorporation. Results :Fisetin, quercetin, apigenin, phloretin, hesperectin, and chalcone (12.5-50μmol/L)concentration-dependently diminished collagen synthesis stimulated by serum, macrophage conditioned medium (MCM)and transforming growth factorβ1(TGFβ1). Conclusion :The six flavonoids inhibited the collagen synthesis of hepatic stellate cells, which may have potential therapeutic effects against liver fibrosis.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Inhibitory effects of six flavonoids on collagen synthesis of rat hepatic stellate cells

  • 1. Department of Pharmacy, Fuzhou General Hospital, PLA Nanjing Military Area Command, Fuzhou 350001, China
  • 2. Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2005-09-14

Abstract: Objective : To study the effects of six flavonoids (fisetin, quercetin, apigenin, phloretin, hesperectin, and chalcone)on collagen synthesis of immortallized rat hepatic stellate cell line HSC-T6 cells. Methods : Collagen synthesis was determined by 3H-proline incorporation. Results :Fisetin, quercetin, apigenin, phloretin, hesperectin, and chalcone (12.5-50μmol/L)concentration-dependently diminished collagen synthesis stimulated by serum, macrophage conditioned medium (MCM)and transforming growth factorβ1(TGFβ1). Conclusion :The six flavonoids inhibited the collagen synthesis of hepatic stellate cells, which may have potential therapeutic effects against liver fibrosis.

Liu Ye, QI Li-Hong, ZHANG Yue-Fan, Xiao Zhen Yu, ZHANG Min, ZHANG Jun-Ping. Inhibitory effects of six flavonoids on collagen synthesis of rat hepatic stellate cells[J]. Journal of Pharmaceutical Practice and Service, 2006, (2): 83-86.
Citation: Liu Ye, QI Li-Hong, ZHANG Yue-Fan, Xiao Zhen Yu, ZHANG Min, ZHANG Jun-Ping. Inhibitory effects of six flavonoids on collagen synthesis of rat hepatic stellate cells[J]. Journal of Pharmaceutical Practice and Service, 2006, (2): 83-86.
shu

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