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Volume 23 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2005  >  (6): 371-374

CHEN Wei-zhong, HE Quan-shan, LIU Xin. Studies on the quality standard and acute toxicity of Shengyu capsule[J]. Journal of Pharmaceutical Practice and Service, 2005, (6): 371-374.
Citation: CHEN Wei-zhong, HE Quan-shan, LIU Xin. Studies on the quality standard and acute toxicity of Shengyu capsule[J]. Journal of Pharmaceutical Practice and Service, 2005, (6): 371-374.
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Studies on the quality standard and acute toxicity of Shengyu capsule

  • 1.

    Department of Pharmacy, Fuzhou General Hospital, Nanjing Military Region, Fuzhou 350025, China

  • 2.

    Department of Pharmacy, Fujian College of TMC, Fuzhou 350003, China

  • Received Date: 2005-07-29
  • Objective To establish the quality standard of Shengyu capsules and to investigate the acute toxicity of the capsules in mice. Methods Thin layer chromatography was used for simultaneously identification of the main components of alcohol extracts of Radix Astragali, Radix Codonopsis, Radix Paeoniae alba and Placenta Hominis in Shengyu capsules. Extractum content of Shengyu capsule was assayed by ethanol extraction method. LD50 of extractum of Shengyu capsule in mice was calculated with modified Karber's method. Results All spots were clear and concentrated on the thin layer. The results have good repeatability. The extractum content of Shengyu capsules was more than 16. 3%. LD50 and its confidence interval of Shengyu capsule in mice were 764.8 mg/kg and 682.5～847.2 mg/kg, respectively. Conclusion The method for determination the quality standard of Shengyu capsule was feasible and precise. The dosage of Shengyu capsule in clinic use was safe.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Studies on the quality standard and acute toxicity of Shengyu capsule

  • 1. Department of Pharmacy, Fuzhou General Hospital, Nanjing Military Region, Fuzhou 350025, China
  • 2. Department of Pharmacy, Fujian College of TMC, Fuzhou 350003, China
  • Received Date: 2005-07-29

Abstract: Objective To establish the quality standard of Shengyu capsules and to investigate the acute toxicity of the capsules in mice. Methods Thin layer chromatography was used for simultaneously identification of the main components of alcohol extracts of Radix Astragali, Radix Codonopsis, Radix Paeoniae alba and Placenta Hominis in Shengyu capsules. Extractum content of Shengyu capsule was assayed by ethanol extraction method. LD50 of extractum of Shengyu capsule in mice was calculated with modified Karber's method. Results All spots were clear and concentrated on the thin layer. The results have good repeatability. The extractum content of Shengyu capsules was more than 16. 3%. LD50 and its confidence interval of Shengyu capsule in mice were 764.8 mg/kg and 682.5～847.2 mg/kg, respectively. Conclusion The method for determination the quality standard of Shengyu capsule was feasible and precise. The dosage of Shengyu capsule in clinic use was safe.

CHEN Wei-zhong, HE Quan-shan, LIU Xin. Studies on the quality standard and acute toxicity of Shengyu capsule[J]. Journal of Pharmaceutical Practice and Service, 2005, (6): 371-374.
Citation: CHEN Wei-zhong, HE Quan-shan, LIU Xin. Studies on the quality standard and acute toxicity of Shengyu capsule[J]. Journal of Pharmaceutical Practice and Service, 2005, (6): 371-374.
shu

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