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GUO Cheng, ZHENG Qing-ming, ZHENG Han-chen. The Study of antidepressant activity of the total flavonoids product from Hypericum sampsonii Hance[J]. Journal of Pharmaceutical Practice and Service, 2005, (6): 345-347,361.
Citation:
GUO Cheng, ZHENG Qing-ming, ZHENG Han-chen. The Study of antidepressant activity of the total flavonoids product from Hypericum sampsonii Hance[J]. Journal of Pharmaceutical Practice and Service, 2005, (6): 345-347,361.
The Study of antidepressant activity of the total flavonoids product from Hypericum sampsonii Hance
Departmemt of Pharmacy, Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233;School of Pharmacy, Second Military Medical University, Shanghai 200433
3.
School of Pharmacy, Second Military Medical University, Shanghai 200433
Received Date: 2005-09-14
Abstract
Objective To observe the antidepressant activity of the active components from Hypericum sampsonii Hance. Methods The total flavonoids product from H. sampsonii were examined by Forced Swimming Test(FST) and Reserpine Reversal Test(RRT) in mice. Results Three doses(150mg/(kg·d), 300mg/(kg·d) and 600mg/(kg·d), i.g.) of the total flavonoids product(contains 68.30% total flavonoids) from H. sampsonii were examined by FST in mice, which reduced duration immobility with dose response by 5.97%, 41.85% and 45.96% respectively. In addition, the different doses of the total flavonoids(150mg/(kg·d), 300mg/(kg·d) and 600mg/(kg·d), i.g.) were examined by RRT, which induced hypothermia by low dose reserpine(5mg/kg, i.p.). In this study, the three doses of total flavonoids reversed hypothermia to some extent but with no dose response relationship. Conclusion The flavonoids compounds are the antidepressant components from H. sampsonii Hance.
2. Departmemt of Pharmacy, Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233;School of Pharmacy, Second Military Medical University, Shanghai 200433
3. School of Pharmacy, Second Military Medical University, Shanghai 200433
Abstract: Objective To observe the antidepressant activity of the active components from Hypericum sampsonii Hance. Methods The total flavonoids product from H. sampsonii were examined by Forced Swimming Test(FST) and Reserpine Reversal Test(RRT) in mice. Results Three doses(150mg/(kg·d), 300mg/(kg·d) and 600mg/(kg·d), i.g.) of the total flavonoids product(contains 68.30% total flavonoids) from H. sampsonii were examined by FST in mice, which reduced duration immobility with dose response by 5.97%, 41.85% and 45.96% respectively. In addition, the different doses of the total flavonoids(150mg/(kg·d), 300mg/(kg·d) and 600mg/(kg·d), i.g.) were examined by RRT, which induced hypothermia by low dose reserpine(5mg/kg, i.p.). In this study, the three doses of total flavonoids reversed hypothermia to some extent but with no dose response relationship. Conclusion The flavonoids compounds are the antidepressant components from H. sampsonii Hance.
GUO Cheng, ZHENG Qing-ming, ZHENG Han-chen. The Study of antidepressant activity of the total flavonoids product from Hypericum sampsonii Hance[J]. Journal of Pharmaceutical Practice and Service, 2005, (6): 345-347,361.
Citation:
GUO Cheng, ZHENG Qing-ming, ZHENG Han-chen. The Study of antidepressant activity of the total flavonoids product from Hypericum sampsonii Hance[J]. Journal of Pharmaceutical Practice and Service, 2005, (6): 345-347,361.
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