Observation on the stability on infusions mixed with norfloxacin by convolution spectrometry

Key words: 
• convolution spectrometry /
• stability of drugs /
• norfloxacin /
• common infusions

Abstract: Objective To observe the chemical stabihty of seven common injections (5% glucose injection, 10% glucose injection, 5% glucose and sodium chloride injection, 10% glucose and sodium chloride injection, compound sodium chloride injection, 0.9% sodium chloride injection, sodium lactate injection) mixed with norfloxacin at room temperature for 8 hours. Methods A convolution spectrometry was used, the appearance was observed and pH value was tested. The results were described quantitatively by subtract spectrometry value. Results There were no obvious changes in the appearances and pH in 8 hours. Except that the subtract spectrometry values of norfloxacin with sodium lactate injection in 4, 6, 8h were 11.51%,19.73%,24.81%, the others were less than 10%. Conclusion Norfloxacin can be mixed with other common injections except sodium lactate injection at room temperature for 8 hours. The convolution spectrometry provides a new method for the research of the stability of drugs.