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Volume 23 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2005  >  (5): 271-272,281

WANG Shao-ming, LIN Cai-jing, YANG Chun-bo, SHI Zuo-lin, ZHUANG Jie, RUAN Jun-shan. Study on the model of gastric mucosal precancerous lesion in rat[J]. Journal of Pharmaceutical Practice and Service, 2005, (5): 271-272,281.
Citation: WANG Shao-ming, LIN Cai-jing, YANG Chun-bo, SHI Zuo-lin, ZHUANG Jie, RUAN Jun-shan. Study on the model of gastric mucosal precancerous lesion in rat[J]. Journal of Pharmaceutical Practice and Service, 2005, (5): 271-272,281.
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Study on the model of gastric mucosal precancerous lesion in rat

  • 1.

    Fujian provincial hospital

  • 2.

    The second people's hospital

  • Received Date: 2005-02-01
  • Objective To establish a practical and effective animal model in order to study gastric mucosal precancerous lesion (GPL) in rat. Methods Three group were classified in the experimental. Normal group:not to establish the model; Model group Ⅰ established the model only use N-methyl-N'-nitro-N'-nitrosoguanididne (MNNG). Model group Ⅱ:established the model by com-plexed method such as the diet, N-methyl-N'-nirtro-N-nitrosoguanidine(MNNG), alcohol, ranitidine and so on. The change of GPL in pathohistologic were observed. Results Experimental GPL of rats were induced successfully. Conclusion It was found that the rate of GPL in model group Ⅱ is higher than that in model group Ⅰ. And the established time was only 20 weeks which was less than 35 weeks that have ever reproted. The model is a practical and effective animal model in studying on GPL in rat.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Study on the model of gastric mucosal precancerous lesion in rat

  • 1. Fujian provincial hospital
  • 2. The second people's hospital
  • Received Date: 2005-02-01

Abstract: Objective To establish a practical and effective animal model in order to study gastric mucosal precancerous lesion (GPL) in rat. Methods Three group were classified in the experimental. Normal group:not to establish the model; Model group Ⅰ established the model only use N-methyl-N'-nitro-N'-nitrosoguanididne (MNNG). Model group Ⅱ:established the model by com-plexed method such as the diet, N-methyl-N'-nirtro-N-nitrosoguanidine(MNNG), alcohol, ranitidine and so on. The change of GPL in pathohistologic were observed. Results Experimental GPL of rats were induced successfully. Conclusion It was found that the rate of GPL in model group Ⅱ is higher than that in model group Ⅰ. And the established time was only 20 weeks which was less than 35 weeks that have ever reproted. The model is a practical and effective animal model in studying on GPL in rat.

WANG Shao-ming, LIN Cai-jing, YANG Chun-bo, SHI Zuo-lin, ZHUANG Jie, RUAN Jun-shan. Study on the model of gastric mucosal precancerous lesion in rat[J]. Journal of Pharmaceutical Practice and Service, 2005, (5): 271-272,281.
Citation: WANG Shao-ming, LIN Cai-jing, YANG Chun-bo, SHI Zuo-lin, ZHUANG Jie, RUAN Jun-shan. Study on the model of gastric mucosal precancerous lesion in rat[J]. Journal of Pharmaceutical Practice and Service, 2005, (5): 271-272,281.
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