Indissoluble particle changes of Xiangdan injection mixed-up with glucose injection

Key words: 
• Xiangdan injection /
• 5% glucose injection /
• indissoluble particle

Abstract: Objective To investigate indissoluble particle of the mixed solution of Xiangdan injection and 5% Glucose injection mixed. It's safety dose was found to decrease harmful reaction. Methods Six difficult proportions solutions mixing Xiangdan injection with 5% glucose injection were provided:4mL : 250 mL、10mL : 250 mL、20mL : 250 mL、30mL : 250 mL、40mL : 250 mL、50mL : 250 mL. According to Chinese Pharmacopoeia, The indissoluble particle was tested. Results The indissoluble particle increased obviously along with proportion of Xiangdan injection increased. Conclusion We must revise quality standard and control dose of Xiangdan injection as fast as possible. It is effective way to decrease harmful reaction of Xiangdan injection.