The susceptibilities test in vitor of 5 species of antifungal drugs

Key words: 
• antifungal drues /
• susceptibility test /
• microdilution method /
• MIC /
• Candida

Abstract: Objective To study the susceptibilities in vitro of the Candida collected from sputum of respiratory tract infectious to 5 species of antifungal drugs, and offer reference for the clinical treatment. Methods The MIC of 43 strains of Candida to fluconazole tablets fiuconazole injectio, intraconazole capsules, allimin injectio were tested by broth microdilution methods according to the National Committee of Clinical Laboratory Standard Recommendations. Results The MIC of fluconazole was 0.8～100μg/mL and 83.7%(36/43) was susceptible; The MIC of fluconazole injectio 6.25～25μg/mL and 100% was susceptible, itraconazle capsules 2.5～10μg/mL and 90.7% was susceptible, allimin injectio 4.69～18.75μg/mL and 100% was susceptible; allimin liquid 0.78～100mg/mL and 88.4% were susceptible. Conclusion We can infer that it was effective for the deep infectious patients for Candida with 12.5μg or more dose of fluconazole injectio or allimin injectious.