Assay for bacteririal endotoxin in papaverine hydrochloride and sodium chloride injection

Key words: 
• papaverine hydrochloride and sodium chlorid injection /
• bacterial endotoxin /
• Gel-clot method

Abstract: OBJECTIVE To establish the method of assay for the bacterial endotoxin in papaverine hydrochlo-ride and sodium chloride injection. METHODS Inhibition and enhancement test was performed with limulus ameboeytc lysate manufactured by two different companies. RESULTS:The injection will not interfere to the bacterial endotoxins test. CONCLUSIONS The results suggest that bacterial endotoxins test(gel-clot method)can be used as an replaceable method for the rabbit pyrogen test for papaverine hydrochloride and sodium chloride injection.