The effect of Carthamus tinctorius injection on blood viscosity, function of platelet , anticoagulation and fibrinolysis of the patient with cor pulmonale

Key words: 
• Carthamus tinctorius injection /
• cor pulmonale /
• platelet /
• fibrinolysis activity

Abstract: OBJECTIVE:To explore the effect of Carthamus tinctorius injection on blood viscosity, platelet , elotting and fibrinolysis in the patients with cor pulmonale. METHODS: 60 patients with acute cor pulmonale are divided into two groups. The 30 patients of control group are treated with routine drugs, the other 30 patients of Carthamus tinctorius group are treated with Carthamus tinctorius (30mL, qd, for 15d as a course) on the basement of routine treatment. Examine the patients' blood viscosity, PAgT-Max, granular membrane protein ( GMP-140), plasminogen (PLg) and tissue-type plasminogen activator ( tpA) of pre-and after the treatment. RESULTS: The total efficient rate of contral group is 86.7% , and its notable efficient rate is 30% ; While in the Carthamus tinctorius group these two figures are 93 % and 60 %. The notable efficient rate in Carthamus tinctorius group is significantly higher than that of control group, (P<0.01 ). After the treatment, the blood viscosity and platelet index of Carthamus tinctorius are significantly lower than before ( P< 0.01-0.05 ) . The antithrombotic and fibrinhlysis activity are significantly higher than that of before the treatment, the PLg, anti thrombin Ⅲ ( AT-Ⅲ ) are significantly higher than before , but the tpA has no significant difference ( P> 0.05 ) . CONCLUSION: The acute cor pulmonale is in a pre-thrombotic state, the Carthamus tinctorius injection can notablely inprove this state, and it suggests that the Carthamus tinctorius injection may play a role in clinical to treat cor pulmonale.