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LIANG Yan-chun, WANG Xiu-li. Study on the reversing effect of tamoxifen on multidrug resistant cell line K562/DOX[J]. Journal of Pharmaceutical Practice and Service, 2001, (5): 264-265.
Citation:
LIANG Yan-chun, WANG Xiu-li. Study on the reversing effect of tamoxifen on multidrug resistant cell line K562/DOX[J]. Journal of Pharmaceutical Practice and Service, 2001, (5): 264-265.
Study on the reversing effect of tamoxifen on multidrug resistant cell line K562/DOX
OBJECTIVE To develop effect of tamoxifen on resistance modulators. METHODS The effects of tamoxifen on drug sensitivity in multidrug resistant human leukemic cell line K562/DOX were studied by MTT corlori- metric assay. RESULTS:Tamoxifen enhanced the cytotoxicity of doxorubicin (DOX) to K562/DOX and had no effect on efflux of DOX in K562 cells. CONCLUSION Tamoxifen is an effective reversal agent of multidrug resistance.
Abstract: OBJECTIVE To develop effect of tamoxifen on resistance modulators. METHODS The effects of tamoxifen on drug sensitivity in multidrug resistant human leukemic cell line K562/DOX were studied by MTT corlori- metric assay. RESULTS:Tamoxifen enhanced the cytotoxicity of doxorubicin (DOX) to K562/DOX and had no effect on efflux of DOX in K562 cells. CONCLUSION Tamoxifen is an effective reversal agent of multidrug resistance.
LIANG Yan-chun, WANG Xiu-li. Study on the reversing effect of tamoxifen on multidrug resistant cell line K562/DOX[J]. Journal of Pharmaceutical Practice and Service, 2001, (5): 264-265.
Citation:
LIANG Yan-chun, WANG Xiu-li. Study on the reversing effect of tamoxifen on multidrug resistant cell line K562/DOX[J]. Journal of Pharmaceutical Practice and Service, 2001, (5): 264-265.
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