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Volume 19 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2001  >  (4): 222-224

LIU Xin-yu, WU Fang, FAN Guo-rong, HU Jin-hong. Determination of content uniformity in levamlodipine besylate tablets by RP-HPLC[J]. Journal of Pharmaceutical Practice and Service, 2001, (4): 222-224.
Citation: LIU Xin-yu, WU Fang, FAN Guo-rong, HU Jin-hong. Determination of content uniformity in levamlodipine besylate tablets by RP-HPLC[J]. Journal of Pharmaceutical Practice and Service, 2001, (4): 222-224.
shu

Determination of content uniformity in levamlodipine besylate tablets by RP-HPLC

  • 1.

    Shenzhen Futian People's Hospital, Shenzhen 518033, China

  • 2.

    Shanghai Changhai Hospital, Shanghai 200433, China

  • Received Date: 2001-03-15
  • OBJECTIVE To develop a new RP-HPLC method was established for the determination of content uniformity in levamlodipine besylate tablets with nicadipine as the internal standard by RP HPLC.METHODS The separation was performed on Hypersil ODS 2(200mm×40mmID,5μm)column with 0.02mol/L sodium dihydrogen phosphate acetonitrile triethylamine(60:40:0.05)as mobile phase.The detection wavelength was 238nm.RESULTS Levamlodipine and nicadipine were isolated within 6min.A good linearity was obtained in the range of 1.642～52.56μg/ml(r=0.9999,n=5)for levamlodipine besylate and the average recovery was 100.8% with the RSD of 0.85%.CONCLUSION The method is simple, rapid, accurate,reliable and suitable for the determination of content uniformity in levamlodipine besylate tablets.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Determination of content uniformity in levamlodipine besylate tablets by RP-HPLC

  • 1. Shenzhen Futian People's Hospital, Shenzhen 518033, China
  • 2. Shanghai Changhai Hospital, Shanghai 200433, China
  • Received Date: 2001-03-15

Abstract: OBJECTIVE To develop a new RP-HPLC method was established for the determination of content uniformity in levamlodipine besylate tablets with nicadipine as the internal standard by RP HPLC.METHODS The separation was performed on Hypersil ODS 2(200mm×40mmID,5μm)column with 0.02mol/L sodium dihydrogen phosphate acetonitrile triethylamine(60:40:0.05)as mobile phase.The detection wavelength was 238nm.RESULTS Levamlodipine and nicadipine were isolated within 6min.A good linearity was obtained in the range of 1.642～52.56μg/ml(r=0.9999,n=5)for levamlodipine besylate and the average recovery was 100.8% with the RSD of 0.85%.CONCLUSION The method is simple, rapid, accurate,reliable and suitable for the determination of content uniformity in levamlodipine besylate tablets.

LIU Xin-yu, WU Fang, FAN Guo-rong, HU Jin-hong. Determination of content uniformity in levamlodipine besylate tablets by RP-HPLC[J]. Journal of Pharmaceutical Practice and Service, 2001, (4): 222-224.
Citation: LIU Xin-yu, WU Fang, FAN Guo-rong, HU Jin-hong. Determination of content uniformity in levamlodipine besylate tablets by RP-HPLC[J]. Journal of Pharmaceutical Practice and Service, 2001, (4): 222-224.
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