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Volume 18 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2000  >  (6): 372-374

JIA Nuan, LIU Jun, BIAN Yan-fang, YUAN Cheng. Pharmacokinetics of tinidazole in patients with lung infection[J]. Journal of Pharmaceutical Practice and Service, 2000, (6): 372-374.
Citation: JIA Nuan, LIU Jun, BIAN Yan-fang, YUAN Cheng. Pharmacokinetics of tinidazole in patients with lung infection[J]. Journal of Pharmaceutical Practice and Service, 2000, (6): 372-374.
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Pharmacokinetics of tinidazole in patients with lung infection

  • Received Date: 2000-04-25
  • OBJECTIVE To determine pharmacokinetics of tinidazole in patients with lung infection.METHODS The concentration of tinidazole in patients'serum was determined by a RP-HPLC method.Metronidazole was being internal standard and a mobile phase of wateracetonitrile-acetic acid(80:20:0 1) were used.There was a good liner relation within the range of 1～50mg/L and the determination limit was 0 1mg/L.Of these patients,5 males and 2 females,were driped intravenously 400mg of tinidazole within 90min.RESULTS The results suggested the pharmacokinetics of administrated tinidazole could be described by a linear two-compartment model.The pharmacokinetic parameters were T1/2α=(2.42±1.75)h,T1/2β=(14.20±4.00)h,AUC0～∞=(219.0±83.9)mg.h/L,Vc=(26.58±11.75)L. CONCLUSIONS There was marker difference for pharmacokinetics of tinidazole among the 7 patients.
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Pharmacokinetics of tinidazole in patients with lung infection

  • Received Date: 2000-04-25

Abstract: OBJECTIVE To determine pharmacokinetics of tinidazole in patients with lung infection.METHODS The concentration of tinidazole in patients'serum was determined by a RP-HPLC method.Metronidazole was being internal standard and a mobile phase of wateracetonitrile-acetic acid(80:20:0 1) were used.There was a good liner relation within the range of 1～50mg/L and the determination limit was 0 1mg/L.Of these patients,5 males and 2 females,were driped intravenously 400mg of tinidazole within 90min.RESULTS The results suggested the pharmacokinetics of administrated tinidazole could be described by a linear two-compartment model.The pharmacokinetic parameters were T1/2α=(2.42±1.75)h,T1/2β=(14.20±4.00)h,AUC0～∞=(219.0±83.9)mg.h/L,Vc=(26.58±11.75)L. CONCLUSIONS There was marker difference for pharmacokinetics of tinidazole among the 7 patients.

JIA Nuan, LIU Jun, BIAN Yan-fang, YUAN Cheng. Pharmacokinetics of tinidazole in patients with lung infection[J]. Journal of Pharmaceutical Practice and Service, 2000, (6): 372-374.
Citation: JIA Nuan, LIU Jun, BIAN Yan-fang, YUAN Cheng. Pharmacokinetics of tinidazole in patients with lung infection[J]. Journal of Pharmaceutical Practice and Service, 2000, (6): 372-374.
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