Effect of Fufang Danshen injection on red cell indexes and the level of lipid-peropxidation in patients with psoriasis

Key words: 
• psoriasis /
• free radical /
• lipid peroxides /
• red cell index /
• Fufang Danshen injection

Abstract: OBJECTIVE To study the effects of Fufang Danshen injection on indexes of red cell and malonyldialdehyde (MDA) content,superoxide enzyme (SOD) and glutathione-peroxidase (GHS-PX) activities in patients with psoriasis.METHODS Fourty-five psoriasis patients were treated with Fufang danshen,injection,compared with fifty normal subjects.We measured their four indexes of red cell,MDA,SOD and GSH-PX of blood.RESULTS The four indexes of psoriasis are all abnormal,especially the levels of mean cell volume (MCV) and mean concentration of hemoglobin (MCHC) (P<0 05).After treated with Fufang Dansen MCV and MCHC of red cell changed obviously,restored to normal levels.The level of MDA in patients increased and the activities of SOD,GSH-PX were decreased.After using Fufang Danshen the level of MDA decreased and SOD,GSH-PX were increased and P<0 05.CONCLUSION The abnormal degree of red cell in four indexes,MDA,SOD and GSH-PX were correlated with the stage of this disease,which suggest that abnormality of indexes of red cell and lipid-peroxidation may play a certain role in the pathogenesis of psoriasis,and this may be used as important reference indexes to judge the severity of the disease and evaluate the therapeutic effect of Fufang Danshen.