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Volume 16 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 1998  >  (5): 292-293,316

Chen Jun, He Fengci. Effect of azone on the permeability of acyclorior cream thought rabbit skin in vitro[J]. Journal of Pharmaceutical Practice and Service, 1998, (5): 292-293,316.
Citation: Chen Jun, He Fengci. Effect of azone on the permeability of acyclorior cream thought rabbit skin in vitro[J]. Journal of Pharmaceutical Practice and Service, 1998, (5): 292-293,316.
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Effect of azone on the permeability of acyclorior cream thought rabbit skin in vitro

  • Department of Pharmacy, Research Institute of Surgery Da-ping Hospital, The Third Military Medical University, Chongqin 400042

  • To investigate the effect of the different concertration of azone on the acyclovir(ACV)cream, in order to optimize the formulation. We determined the transdermal amount of the ACV and steady-state-rate of penetration in vitro, using the improved-Frenz cell and excised rabbit skin as transdermal barrier in permeation test. The result indicated transdermal absorption of ACV followed zeroorder kinetics, and the penetration enhance effect of Azone was independent with the concertration. The ACV cream containing 2% Azone showed remarkable effect to enhance the transdermal delivery amount of ACV.
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Effect of azone on the permeability of acyclorior cream thought rabbit skin in vitro

  • Department of Pharmacy, Research Institute of Surgery Da-ping Hospital, The Third Military Medical University, Chongqin 400042

Abstract: To investigate the effect of the different concertration of azone on the acyclovir(ACV)cream, in order to optimize the formulation. We determined the transdermal amount of the ACV and steady-state-rate of penetration in vitro, using the improved-Frenz cell and excised rabbit skin as transdermal barrier in permeation test. The result indicated transdermal absorption of ACV followed zeroorder kinetics, and the penetration enhance effect of Azone was independent with the concertration. The ACV cream containing 2% Azone showed remarkable effect to enhance the transdermal delivery amount of ACV.

Chen Jun, He Fengci. Effect of azone on the permeability of acyclorior cream thought rabbit skin in vitro[J]. Journal of Pharmaceutical Practice and Service, 1998, (5): 292-293,316.
Citation: Chen Jun, He Fengci. Effect of azone on the permeability of acyclorior cream thought rabbit skin in vitro[J]. Journal of Pharmaceutical Practice and Service, 1998, (5): 292-293,316.
shu

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