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LI Yu, ZHAO Jing-xia, YANG Gen-jin, DONG Xin, LI Ling, SU Li, ZHANG Wei. Determination of residual by headspace gas chromatography organic solvents in piroxicam[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 31-32.
Citation:
Chen Jun, He Fengci. Effect of azone on the permeability of acyclorior cream thought rabbit skin in vitro[J]. Journal of Pharmaceutical Practice and Service, 1998, (5): 292-293,316.
Effect of azone on the permeability of acyclorior cream thought rabbit skin in vitro
Department of Pharmacy, Research Institute of Surgery Da-ping Hospital, The Third Military Medical University, Chongqin 400042
Abstract
To investigate the effect of the different concertration of azone on the acyclovir(ACV)cream, in order to optimize the formulation. We determined the transdermal amount of the ACV and steady-state-rate of penetration in vitro, using the improved-Frenz cell and excised rabbit skin as transdermal barrier in permeation test. The result indicated transdermal absorption of ACV followed zeroorder kinetics, and the penetration enhance effect of Azone was independent with the concertration. The ACV cream containing 2% Azone showed remarkable effect to enhance the transdermal delivery amount of ACV.
Abstract: To investigate the effect of the different concertration of azone on the acyclovir(ACV)cream, in order to optimize the formulation. We determined the transdermal amount of the ACV and steady-state-rate of penetration in vitro, using the improved-Frenz cell and excised rabbit skin as transdermal barrier in permeation test. The result indicated transdermal absorption of ACV followed zeroorder kinetics, and the penetration enhance effect of Azone was independent with the concertration. The ACV cream containing 2% Azone showed remarkable effect to enhance the transdermal delivery amount of ACV.
LI Yu, ZHAO Jing-xia, YANG Gen-jin, DONG Xin, LI Ling, SU Li, ZHANG Wei. Determination of residual by headspace gas chromatography organic solvents in piroxicam[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 31-32.
Citation:
Chen Jun, He Fengci. Effect of azone on the permeability of acyclorior cream thought rabbit skin in vitro[J]. Journal of Pharmaceutical Practice and Service, 1998, (5): 292-293,316.
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LI Yu, ZHAO Jing-xia, YANG Gen-jin, DONG Xin, LI Ling, SU Li, ZHANG Wei. Determination of residual by headspace gas chromatography organic solvents in piroxicam[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 31-32.
LI Yu, ZHAO Jing-xia, YANG Gen-jin, DONG Xin, LI Ling, SU Li, ZHANG Wei. Determination of residual by headspace gas chromatography organic solvents in piroxicam[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(1): 31-32.
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