Pharmacokinetic analysis and individual administration of cyclosporine for a juvenile renal transplant patients

Key words: 
• renal transplant /
• cyclosporine /
• pharmacokinetic analysis /
• individual administration

Abstract: It was reported that a juvenile renal transplant patients had a low cyclosporine whole blood concentration after normal administration.The pharmacokinetic parameters were: T_1/2(Ke) = 3.15h, T_max = 1.88h,C_max=498.41ng·ml^-1,AUC=3188.65(ng·ml^-1)·h^-1.Computer software was used to design the individual administration, that was 200mg, tid. Satisfactory effect was acquired.