The postantibiotic effect and new administrative regimen of aminoglycosides

Key words: 
• aminoglycosides /
• postantibiotic effect /
• postexposure resistance /
• nephrotoxicity /
• ototoxicity

Abstract: The postantibiotic effect(PAE)is reviewed in this article, which provides theory basis for once-daily administration of aminoglycosides. The new regimen has equally effective as traditional regimens. Also,it may delays the occurance for postexposure resistance by reducing contact time between the organism and the drug,and reduces nephrotoxicity and ototoxicity that caused by the accumulation of drugs, The data on studies has shown that once-daily administration of aminoglycosides is advisable. Patients, espacially the patient with renal dysfunction,may benifit from once-daily administration of aminoglycosides.