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Volume 13 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 1995  >  (2): 72-75

Tang Zhong-jin, Wang Xiu-ying, Chen Hong, Guan Ying, Zhu Quan-ying, Su Ding-feng. Effect of tetrandrine on 45Ca influx in rat aorta in vitro[J]. Journal of Pharmaceutical Practice and Service, 1995, (2): 72-75.
Citation: Tang Zhong-jin, Wang Xiu-ying, Chen Hong, Guan Ying, Zhu Quan-ying, Su Ding-feng. Effect of tetrandrine on 45Ca influx in rat aorta in vitro[J]. Journal of Pharmaceutical Practice and Service, 1995, (2): 72-75.
shu

Effect of tetrandrine on 45Ca influx in rat aorta in vitro

  • 1.

    Department of Pharmacology, Faculty of Basic Medincine, Second Military Medical University Shanghai 200433

  • 2.

    Department of Pharmacology, Faculty of Basic Medincine, Second Military Medical University Shanghai 200433

  • The effects of tetrandrine on calcium influx were studied in rat aorta in vitro.It was found that tetrandrine, similar to verapamil, significantly inhibited high-K+-induced 45Ca influx. But tetrandrine could not inhibit 45Ca influx evoked by phenylephrine, These results suggest that tetrandrine has a specific inhibitary effect on smooth muscle 45Ca influx by inhibiting voltage-operated calcium channel.
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Effect of tetrandrine on 45Ca influx in rat aorta in vitro

  • 1. Department of Pharmacology, Faculty of Basic Medincine, Second Military Medical University Shanghai 200433
  • 2. Department of Pharmacology, Faculty of Basic Medincine, Second Military Medical University Shanghai 200433

Abstract: The effects of tetrandrine on calcium influx were studied in rat aorta in vitro.It was found that tetrandrine, similar to verapamil, significantly inhibited high-K+-induced 45Ca influx. But tetrandrine could not inhibit 45Ca influx evoked by phenylephrine, These results suggest that tetrandrine has a specific inhibitary effect on smooth muscle 45Ca influx by inhibiting voltage-operated calcium channel.

Tang Zhong-jin, Wang Xiu-ying, Chen Hong, Guan Ying, Zhu Quan-ying, Su Ding-feng. Effect of tetrandrine on 45Ca influx in rat aorta in vitro[J]. Journal of Pharmaceutical Practice and Service, 1995, (2): 72-75.
Citation: Tang Zhong-jin, Wang Xiu-ying, Chen Hong, Guan Ying, Zhu Quan-ying, Su Ding-feng. Effect of tetrandrine on 45Ca influx in rat aorta in vitro[J]. Journal of Pharmaceutical Practice and Service, 1995, (2): 72-75.
shu

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