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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2013  >  31(3): 198-200

NIU Shai-long, SUN Fu-zeng, Zhang Xing-nai. Anti-inflammatory mechanisms of Gentiana macrophylla iridoid glucoside[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 198-200. doi: 10.3969/j.issn.1006-0111.2013.03.010
Citation: NIU Shai-long, SUN Fu-zeng, Zhang Xing-nai. Anti-inflammatory mechanisms of Gentiana macrophylla iridoid glucoside[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 198-200. doi: 10.3969/j.issn.1006-0111.2013.03.010
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Anti-inflammatory mechanisms of Gentiana macrophylla iridoid glucoside

doi: 10.3969/j.issn.1006-0111.2013.03.010

  • Department of Pharmacy, Jiangsu Provincial Corps Hospital of Chinese People's Armed Police Forces, Yangzhou 225003, China

  • Received Date: 2012-11-20
  • Rev Recd Date: 2013-04-10
  • Objective To observe effects of different concentrations of the Gentiana macrophylla iridoid glucoside(GMI) in different period inflammatory models, and discuss the possibility of anti-inflammation. Methods The anti-inflammatory models of GMI were investigated in mice by methods of the capillary permeability increase (AIPCPI), the cotton-pellet induced-granuloma(CPIG) xylene-induced auricle swelling (XIAS), intraperitoneal injection of acetic acid-induced peritoneal capilnd egg white-induced balloon back synovial inflammation. Levels of XIAS and CPIG in mouse were detected by weighing. Levels of mouse peritoneal washing fluid in the content of Evans blue, synovitis exudate volume, white blood cells(WBC), tumor necrosis factor(TNF-α), the exudate and serum levels of superoxide dismutase(SOD) and malondialdehyde were determined by chemical method respectively. Result Compared with negative control group, levels of XIAS, AIPCPI and CPIG decreased significantly in GMI group. Levels of WBC, MDA and TNF-α significantly decreased in GMI group than those of negative control group, but the activity of the exudate and serum SOD increased significantly in GMI group compared with that of negative control group. Conclusion The GMI showed protective effects on inflammation in animal models, which might be mediated through inhibition of the exudation of inflammatory factors, the lipid peroxidation and the elimination of free radicals.
  • [1] 中国科学院中国植物志编辑委员会.中国植物志,第1版[M].北京:科学出版社,1988:62.
    [2] Tan Rx,Wolfender JL,Zhang LX,et al.Acyl secoiridiods and antifungal constituents from Gentiana macrophylla[J].Phytochem,1996,42(5):1305.
    [3] 刘艳红, 李兴从, 刘玉清, 等. 秦艽中的环烯醚萜苷类成分[J].云南植物研究, 1995, 15(1):85.
    [4] 张均智,莫 刚,杨成芳,等. 茅莓正丁醇组分的抗炎作用[J].中国实验方剂学杂志,2011,17(8):204.
    [5] 钱海兵,蒲金山,王 龙,等.苗药铁筷子挥发油的抗炎作用研究[J].时珍国医国药,2012,23(8):1961.
    [6] 王 玮, 白 月, 王俊平, 等. 黄芩茎叶总黄酮对大鼠气囊滑膜炎抗炎作用机制的研究[J]. 临床与用药, 2009, 26(4):460.
    [7] 韩 磊, 向云霞, 徐 磊. 中药抗炎与免疫药理[J]. 新疆中医药, 2011, 29(4):114.
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Anti-inflammatory mechanisms of Gentiana macrophylla iridoid glucoside

doi: 10.3969/j.issn.1006-0111.2013.03.010
  • Department of Pharmacy, Jiangsu Provincial Corps Hospital of Chinese People's Armed Police Forces, Yangzhou 225003, China
  • Received Date: 2012-11-20
  • Rev Recd Date: 2013-04-10

Abstract: Objective To observe effects of different concentrations of the Gentiana macrophylla iridoid glucoside(GMI) in different period inflammatory models, and discuss the possibility of anti-inflammation. Methods The anti-inflammatory models of GMI were investigated in mice by methods of the capillary permeability increase (AIPCPI), the cotton-pellet induced-granuloma(CPIG) xylene-induced auricle swelling (XIAS), intraperitoneal injection of acetic acid-induced peritoneal capilnd egg white-induced balloon back synovial inflammation. Levels of XIAS and CPIG in mouse were detected by weighing. Levels of mouse peritoneal washing fluid in the content of Evans blue, synovitis exudate volume, white blood cells(WBC), tumor necrosis factor(TNF-α), the exudate and serum levels of superoxide dismutase(SOD) and malondialdehyde were determined by chemical method respectively. Result Compared with negative control group, levels of XIAS, AIPCPI and CPIG decreased significantly in GMI group. Levels of WBC, MDA and TNF-α significantly decreased in GMI group than those of negative control group, but the activity of the exudate and serum SOD increased significantly in GMI group compared with that of negative control group. Conclusion The GMI showed protective effects on inflammation in animal models, which might be mediated through inhibition of the exudation of inflammatory factors, the lipid peroxidation and the elimination of free radicals.

NIU Shai-long, SUN Fu-zeng, Zhang Xing-nai. Anti-inflammatory mechanisms of Gentiana macrophylla iridoid glucoside[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 198-200. doi: 10.3969/j.issn.1006-0111.2013.03.010
Citation: NIU Shai-long, SUN Fu-zeng, Zhang Xing-nai. Anti-inflammatory mechanisms of Gentiana macrophylla iridoid glucoside[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 198-200. doi: 10.3969/j.issn.1006-0111.2013.03.010
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