YUAN Yuan, HUANG Gang-hui, LI Xia, WANG Yan, SUN Lian-na. α-Glucosidase inhibitory activity of extracts from roots of Salacia amplifolia Merr.ex ChunF.C.[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 185-186,237. doi: 10.3969/j.issn.1006-0111.2013.03.006
| Citation:
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YUAN Yuan, HUANG Gang-hui, LI Xia, WANG Yan, SUN Lian-na. α-Glucosidase inhibitory activity of extracts from roots of Salacia amplifolia Merr.ex ChunF.C.[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 185-186,237. doi: 10.3969/j.issn.1006-0111.2013.03.006
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α-Glucosidase inhibitory activity of extracts from roots of Salacia amplifolia Merr.ex ChunF.C.
- 1.
The 85th hospital of PLA, Shanghai 200052, China
- 2.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China;School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China
- 3.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- 4.
Department of Pharmacy, Fujian Health college, Fujian Fuzhou 350101, China
- Received Date: 2013-01-31
- Rev Recd Date:
2013-04-27
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Abstract
Objective To investigate different extracts of Salacia amplifolia Merr.ex ChunF.C on inhibitory activity to α-glucosidase. Methods The 80% aqueous ethanol extracts from roots of S.amplifolia, which were partitioned sequentially with petroleum ether, EtOAc and n-BuOH respectively to yield four different fractions. And the inhibitory activity of these five extracts for the α-glucosidase and α-amylase were determined by in vitro experiments. Results Five kinds of extracts showed moderate inhibitory activity at the same time and close to acarbose to a certain degree.Inhibitory activity of α-glucosidase were, n-BuOH fraction > petroleum ether fraction > EtOAc fraction > total fraction.The inhibitory of α-amylase activity followed by petroleum ether fraction > n-BuOH fraction > total fraction > EtOAc fraction, respectively. Conclusion The extracts from S.amplifolia had good inhibitory activity on α-glucosidase, which could be exploited the diabetes drugs as α-glucosidases inhibitors in future.
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