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GAO Yanxia, SU Juan, JIN Huizi. Study on HPLC fingerprint of Ginseng Radix et Rhizoma Rubra[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 249-251,254. doi: 10.3969/j.issn.1006-0111.2016.03.014
Citation:
WANG Ke-bing, GAO Qun, LI Hao, LU Feng. Study on brand counterfeit drugs detection methods by Raman spectroscopy[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 108-112. doi: 10.3969/j.issn.1006-0111.2013.02.007
Study on brand counterfeit drugs detection methods by Raman spectroscopy
Department of pharmacy, the 169th Hospital of PLA, Hengyang 421002, China
2.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China
Received Date: 2013-01-08
Rev Recd Date:
2013-02-18
Abstract
Objective To established a two-step discriminant method based on SVM and HQI or PCA, in which cephalexin capsules from several domestic manufacturers were used as tool drugs for counterfeits of brand drugs appear on the market. Method In the first step, a simulating classification model of cephalexin brand capsules and 4 kinds of counterfeit drugs was built, the cross-validation accuracy was 95.63%, and prediction accuracy of suspicious samples within the model was 93.75%, and the false-positive rate of additional homemade test samples was 25%. In the second step, the positive samples were applied to HQI and PCA methods, and the false positive rate could be reduced to 5% and 0% respectively. Results and Conclusion The two-step discrimination method established in our study could detected counterfeits of brand drugs efficiently and accurately.
Been F, Roggo Y, Degardin K,et al.Profiling of counterfeit medicines by vibrational spectroscopy[J].Forensic Sci Int,2011,211:83.
[3]
Dégardin K,Roggo Y,Been F,et al.Detection and chemical profiling of medicine counterfeits by Raman spectroscopy and chemometrics[J].Anal Chim Acta, 2011,705:334.
[4]
Storme-Parisa I, Rebiereb H, Matogaa M,et al.Challenging Near InfraRed Spectroscopy discriminating ability for counterfeit pharmaceuticals detection[J].Anal Chim Acta,2010,658:163.
[5]
Dégardin K,Roggo Y,Been F,et al.Detection and chemical profiling of medicine counterfeits by Raman spectroscopy and chemometrics[J].Anal Chim Acta,2011,705:334.
[6]
Been F,Roggo Y,Degardin K,et al. Profiling of counterfeit medicines by vibrational spectroscopy[J].Forensic Sci Int,211:83.
[7]
Westerhuis J, Hoefsloot H, Smit S, et al. Assessment of PLS-DA cross validation[J]. Metabolomics,2008,4:81.
Abstract: Objective To established a two-step discriminant method based on SVM and HQI or PCA, in which cephalexin capsules from several domestic manufacturers were used as tool drugs for counterfeits of brand drugs appear on the market. Method In the first step, a simulating classification model of cephalexin brand capsules and 4 kinds of counterfeit drugs was built, the cross-validation accuracy was 95.63%, and prediction accuracy of suspicious samples within the model was 93.75%, and the false-positive rate of additional homemade test samples was 25%. In the second step, the positive samples were applied to HQI and PCA methods, and the false positive rate could be reduced to 5% and 0% respectively. Results and Conclusion The two-step discrimination method established in our study could detected counterfeits of brand drugs efficiently and accurately.
GAO Yanxia, SU Juan, JIN Huizi. Study on HPLC fingerprint of Ginseng Radix et Rhizoma Rubra[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 249-251,254. doi: 10.3969/j.issn.1006-0111.2016.03.014
Citation:
WANG Ke-bing, GAO Qun, LI Hao, LU Feng. Study on brand counterfeit drugs detection methods by Raman spectroscopy[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 108-112. doi: 10.3969/j.issn.1006-0111.2013.02.007
Been F, Roggo Y, Degardin K,et al.Profiling of counterfeit medicines by vibrational spectroscopy[J].Forensic Sci Int,2011,211:83.
[3]
Dégardin K,Roggo Y,Been F,et al.Detection and chemical profiling of medicine counterfeits by Raman spectroscopy and chemometrics[J].Anal Chim Acta, 2011,705:334.
[4]
Storme-Parisa I, Rebiereb H, Matogaa M,et al.Challenging Near InfraRed Spectroscopy discriminating ability for counterfeit pharmaceuticals detection[J].Anal Chim Acta,2010,658:163.
[5]
Dégardin K,Roggo Y,Been F,et al.Detection and chemical profiling of medicine counterfeits by Raman spectroscopy and chemometrics[J].Anal Chim Acta,2011,705:334.
[6]
Been F,Roggo Y,Degardin K,et al. Profiling of counterfeit medicines by vibrational spectroscopy[J].Forensic Sci Int,211:83.
[7]
Westerhuis J, Hoefsloot H, Smit S, et al. Assessment of PLS-DA cross validation[J]. Metabolomics,2008,4:81.
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GAO Yanxia, SU Juan, JIN Huizi. Study on HPLC fingerprint of Ginseng Radix et Rhizoma Rubra[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 249-251,254. doi: 10.3969/j.issn.1006-0111.2016.03.014
GAO Yanxia, SU Juan, JIN Huizi. Study on HPLC fingerprint of Ginseng Radix et Rhizoma Rubra[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 249-251,254. doi: 10.3969/j.issn.1006-0111.2016.03.014
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