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Volume 31 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2013  >  31(2): 98-101,107

ZOU Hao, LIU Jun-jie, CHEN Yan, LU Ying, ZHANG Chuan, ZHONG Yan-qiang. Modulation of combined-release behaviors from pulsatile release tablet[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 98-101,107. doi: 10.3969/j.issn.1006-0111.2013.02.005
Citation: ZOU Hao, LIU Jun-jie, CHEN Yan, LU Ying, ZHANG Chuan, ZHONG Yan-qiang. Modulation of combined-release behaviors from pulsatile release tablet[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 98-101,107. doi: 10.3969/j.issn.1006-0111.2013.02.005
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Modulation of combined-release behaviors from pulsatile release tablet

doi: 10.3969/j.issn.1006-0111.2013.02.005

  • School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2012-07-05
  • Rev Recd Date: 2012-10-29
  • Objective To design and evaluate a multifunctional and multiple unit oral DDS, which depends on the preparations of pulsatile release mini-tablets. Methods Based on the combinations of pulsatile release tablets, zero-order DDS could be obtained. Velocity-time curve, instead of the cumulative percentage drug release profile, was plotted. The nonlinear least square model fit program was applied to process the velocity data of dissolution. The test curves coincided with the theoretical curves from simple summation of v-t equations of individual pulsatile release tablets. Results Zero-order DDS were designed with two kinds of combinations. The amount of the two pulsatile should be 1:1. The combination of pulsatile release tablet could achieved the formulation from which Acetaminophen and Pseudoephedrine could be released in the same proportion. Conclusion The combination of delayed-onset sustained-release Tablet was better fit in with zero-order equation and Acetaminophen and Pseudoephedrine could be released in the same proportion.
  • [1] 阳长明.浅谈中药缓释制剂的研究[J].中国新药与临床药理,2003,14(4):282.
    [2] 马建民,李 宏,王东风.中药缓释制剂的研究[J].中成药,2003,25(7):581.
    [3] 薛 燕.中药复方霰弹理论——论中药复方现代化研究方法[J].北京:中国医药出版社,1998.
    [4] 周 俊.中药复方——天然组合化学库与多靶点作用机理[J].中成药,1997,19(8):67.
    [5] Bussemer T, Bodmeier R. Formulation parameters affecting the performance of coated gelatin capsules with pulsatile release profiles[J]. Int J Pharmaceut,2003,(267):59.
    [6] Bussemer T, Peppas NA, Bodmeier R. Evaluation of the swelling, hydration and rupturing properties of the swelling layer of a rupturable pulsatile drug delivery system[J]. Eur J Pharm Biopharm,2003,(56):261.
    [7] Li YH, Zhu JB. Modulation of combined-release behaviors from a novel “tablets-in-capsule system” [J]. J Control Release, 2004, (95):120.
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Modulation of combined-release behaviors from pulsatile release tablet

doi: 10.3969/j.issn.1006-0111.2013.02.005
  • School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2012-07-05
  • Rev Recd Date: 2012-10-29

Abstract: Objective To design and evaluate a multifunctional and multiple unit oral DDS, which depends on the preparations of pulsatile release mini-tablets. Methods Based on the combinations of pulsatile release tablets, zero-order DDS could be obtained. Velocity-time curve, instead of the cumulative percentage drug release profile, was plotted. The nonlinear least square model fit program was applied to process the velocity data of dissolution. The test curves coincided with the theoretical curves from simple summation of v-t equations of individual pulsatile release tablets. Results Zero-order DDS were designed with two kinds of combinations. The amount of the two pulsatile should be 1:1. The combination of pulsatile release tablet could achieved the formulation from which Acetaminophen and Pseudoephedrine could be released in the same proportion. Conclusion The combination of delayed-onset sustained-release Tablet was better fit in with zero-order equation and Acetaminophen and Pseudoephedrine could be released in the same proportion.

ZOU Hao, LIU Jun-jie, CHEN Yan, LU Ying, ZHANG Chuan, ZHONG Yan-qiang. Modulation of combined-release behaviors from pulsatile release tablet[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 98-101,107. doi: 10.3969/j.issn.1006-0111.2013.02.005
Citation: ZOU Hao, LIU Jun-jie, CHEN Yan, LU Ying, ZHANG Chuan, ZHONG Yan-qiang. Modulation of combined-release behaviors from pulsatile release tablet[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 98-101,107. doi: 10.3969/j.issn.1006-0111.2013.02.005
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