Progress on Human aldehyde dehydrogenase II and its agonists

TIAN Wei; WANG Tao; ZHENG Can-hui; DONG Guo-qiang; LV jia-guo; ZHU Ju

doi:10.3969/j.issn.1006-0111.2013.02.004

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Volume 31 Issue 2

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2013 > 31(2): 94-97,112

TIAN Wei, WANG Tao, ZHENG Can-hui, DONG Guo-qiang, LV jia-guo, ZHU Ju. Progress on Human aldehyde dehydrogenase II and its agonists[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 94-97,112. doi: 10.3969/j.issn.1006-0111.2013.02.004

Citation:

TIAN Wei, WANG Tao, ZHENG Can-hui, DONG Guo-qiang, LV jia-guo, ZHU Ju. Progress on Human aldehyde dehydrogenase II and its agonists[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 94-97,112. doi: 10.3969/j.issn.1006-0111.2013.02.004

Progress on Human aldehyde dehydrogenase II and its agonists

doi: 10.3969/j.issn.1006-0111.2013.02.004

Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2012-04-26
Rev Recd Date: 2012-11-12

Abstract

The aldehyde dehydrogenase II (ALDH2) could act as both esterase and dehydrogenase. The improvement of ALDH2 activity might reduce the damage caused by alcohol and ischemia and avoid the occurrence of some certain cancers. The outline of ALDH2 and its agonists were summarized concisely through literature analysis, collation and induction in this paper.
- aldehyde dehydrogenase II (ALDH2),
- agonist,
- alda-1

References

[1]	毛根年,李鑫,瞿建波.乙醛脱氢酶及其医疗领域研究进展[J].天然产物研究与开发,2011,23:193.
[2]	Wojciech J, Emilia K, Magdalena LD, et al. Alcohol Dehydrogenase (ADH) and Aldehyde Dehydrogenase (ALDH) as Candidates for Tumor markers in Patients with Pancreatic Cancer[J]. J Gastrointestin Liver Dis,2011, 20:255.
[3]	Jose C,Jimenez L, Emma WG, et al.The maize ALDH protein superfamily:linking structural features to functional specificities[J]. BMC Structural Biology,2010, 10:43.
[4]	何岚,彭军.线粒体醛脱氢酶对心脏保护作用的研究进展[J].中国药理学通报,2009,25:1548.
[5]	罗怀荣,张亚平.乙醛脱氢酶2(ALDH2)基因研究进展及其与饮酒行为的关系[J].遗传,2004,26:263.
[6]	Che HC, Li HS, Daria MR. Mitochondrial aldehyde dehydrogenase and cardiac diseases[J]. Cardiovascular Research,2010,88:51.
[7]	Samantha PM, Hina YRV, Che HC, et al. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant[J]. Nature Structural & Molecular Biology,2010,17:159.
[8]	Chen CB.Crystal structure of aldehyde dehydrogenase and methods 0f use tilereof[J].World intellectual property organization,2009,18:1.
[9]	Curtis GS, Pei X, Henry W,et al.Structure of mitochondrial aldehyde dehydrogenase:the genetic component of ethanol aversion[J]. Structure,1997,5:701.
[10]	Jiali W, Haigang W, Panpan H, et al. Inhibition of Aldehyde Dehydrogenase 2 by Oxidative Stress Is Associated with Cardiac Dysfunction in Diabetic Rats[J]. MOL MED, 2011,17:172.
[11]	Grant RB, Marie HD, Daria MR,et al. Aldehyde Dehydrogenase 2 in Cardiac Protection:A New Therapeutic Target[J]. TCM, 2009,19:159.
[12]	刘非凡,唐瑛,陈忠庆,等.地塞米松治疗双硫仑样反应的临床和实验研究[J]. 内科急危重症杂志,2008,14:205.
[13]	陈玉国,张运.乙醛脱氢酶2与硝酸酯耐药关系的研究进展[J].心血管病学进展,2010,31:50.
[14]	Martin WH, Sonja S, Michael W, et al. Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins[J]. The FASEB Journal, 2008,22:2561.
[15]	王群英,刘新伟.硝酸甘油及线粒体乙醛脱氢酶对心肌保护作用的研究进展[J].心血管病学进展,2010,31:708.
[16]	Grant RB, Marie HD, Che HC, et al. Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon knockout mice[J]. Journal of Molecular and Cellular Cardiology,2010,48:757.
[17]	Eric NC, Marie HD, Daria MR. Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of εPKC and activation of aldehyde dehydrogenase 2 [J]. J Mol Cell Cardiol, 2009, 46:278.
[18]	Che H C, Lihan S, Daria MR. Mitochondrial aldehyde dehydrogenase and cardiac diseases[J]. Cardiovascular Research,2010, 88:51.
[19]	Perez M, Samantha YH, Vanam R, et al. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant[J]. Nature Structural & Molecular Biology,2010, 17:159.
[20]	Matteo B, Antonius CF, Gorren M, et al. Characterization of the East Asian Variant of Aldehyde Dehydrogenase-2[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2010,285:943.
[21]	Grant RB, Marie HD, Daria MR. Aldehyde Dehydrogenase 2 in Cardiac Protection:A New Therapeutic Target[J]. TCM, 2009,19:159.
[22]	Samantha PM, Hina Y, Ram V, et al. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant[J]. Nature Structural & Molecular Biology, 2010,17:159.
[23]	Feldman RI, Weiner H. Horse liver aldehyde dehydrogenaseII Kinetics and mechanistic implications of the dehydrogenase and esterase activity[J]. J Biol Chem, 1972,5:267.
[24]	Takahashi K,Weiner W. Nicotinamide adenine dinucleotide activation of the esterase reaction of horse liver aldehyde dehydrogenase dehydrogenase[J].Biochemistry,1981,20:2720.
[25]	Mukerjee N,Pietruszko R. Human mitochondrial aldehyde dehydrogenase substrate specificity:comparison of esterase with dehydrogenase reaction[J]. Arch Biochem Biophys, 1992, 299:23.
[26]	Perez MS, Hurley TD. Coenzyme isomerization is integral to catalysis in human aldehyde dehydrogenase[J]. Biochemistry, 2003,42:7100.
[27]	Hammen PK, Allali HA, Hallenga K, et al. Multiple conformations of NAD and NADH when bound to human cytosolic and mitochondrial aldehyde dehydrogenase[J]. Biochemistry,2002,41:7156.
[28]	Suzuki Y, Ogawa S,Sakakibara Y. Chaperone therapy for neuronopathic lysosomal diseases:competitive inhibitors as chemical chaperones for enchancement of mutant enzyme activities[J]. Perspect Medicin Chem, 2009,3:7.
[29]	Lowe ED, Gao GY, Johnson LN,et al. Structure of daidzin, a naturally occurring anti-alcohol-addiction agent in complex with human mitochondrial aldehyde dehydrogenase[J]. J Med Chem,2008,51:4482.
[30]	Eun JC, Hak CK, Young CS, et al. Four Flavonoids from Echinosophora koreensis and their Effects on Alcohol Metabolizing Enzymes[J]. Arch Pharm Res, 2009, 32:851.
[31]	汤子春,邹坤,陆海华.开口箭与筒鞘蛇菰提取物醒酒作用机制的研究[J].时珍国医国药,2007,18:2958.

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Progress on Human aldehyde dehydrogenase II and its agonists

Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2012-04-26

Rev Recd Date: 2012-11-12

Key words:

Abstract: The aldehyde dehydrogenase II (ALDH2) could act as both esterase and dehydrogenase. The improvement of ALDH2 activity might reduce the damage caused by alcohol and ischemia and avoid the occurrence of some certain cancers. The outline of ALDH2 and its agonists were summarized concisely through literature analysis, collation and induction in this paper.

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Reference (31)

[1]	毛根年,李鑫,瞿建波.乙醛脱氢酶及其医疗领域研究进展[J].天然产物研究与开发,2011,23:193.
[2]	Wojciech J, Emilia K, Magdalena LD, et al. Alcohol Dehydrogenase (ADH) and Aldehyde Dehydrogenase (ALDH) as Candidates for Tumor markers in Patients with Pancreatic Cancer[J]. J Gastrointestin Liver Dis,2011, 20:255.
[3]	Jose C,Jimenez L, Emma WG, et al.The maize ALDH protein superfamily:linking structural features to functional specificities[J]. BMC Structural Biology,2010, 10:43.
[4]	何岚,彭军.线粒体醛脱氢酶对心脏保护作用的研究进展[J].中国药理学通报,2009,25:1548.
[5]	罗怀荣,张亚平.乙醛脱氢酶2(ALDH2)基因研究进展及其与饮酒行为的关系[J].遗传,2004,26:263.
[6]	Che HC, Li HS, Daria MR. Mitochondrial aldehyde dehydrogenase and cardiac diseases[J]. Cardiovascular Research,2010,88:51.
[7]	Samantha PM, Hina YRV, Che HC, et al. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant[J]. Nature Structural & Molecular Biology,2010,17:159.
[8]	Chen CB.Crystal structure of aldehyde dehydrogenase and methods 0f use tilereof[J].World intellectual property organization,2009,18:1.
[9]	Curtis GS, Pei X, Henry W,et al.Structure of mitochondrial aldehyde dehydrogenase:the genetic component of ethanol aversion[J]. Structure,1997,5:701.
[10]	Jiali W, Haigang W, Panpan H, et al. Inhibition of Aldehyde Dehydrogenase 2 by Oxidative Stress Is Associated with Cardiac Dysfunction in Diabetic Rats[J]. MOL MED, 2011,17:172.
[11]	Grant RB, Marie HD, Daria MR,et al. Aldehyde Dehydrogenase 2 in Cardiac Protection:A New Therapeutic Target[J]. TCM, 2009,19:159.
[12]	刘非凡,唐瑛,陈忠庆,等.地塞米松治疗双硫仑样反应的临床和实验研究[J]. 内科急危重症杂志,2008,14:205.
[13]	陈玉国,张运.乙醛脱氢酶2与硝酸酯耐药关系的研究进展[J].心血管病学进展,2010,31:50.
[14]	Martin WH, Sonja S, Michael W, et al. Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins[J]. The FASEB Journal, 2008,22:2561.
[15]	王群英,刘新伟.硝酸甘油及线粒体乙醛脱氢酶对心肌保护作用的研究进展[J].心血管病学进展,2010,31:708.
[16]	Grant RB, Marie HD, Che HC, et al. Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon knockout mice[J]. Journal of Molecular and Cellular Cardiology,2010,48:757.
[17]	Eric NC, Marie HD, Daria MR. Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of εPKC and activation of aldehyde dehydrogenase 2 [J]. J Mol Cell Cardiol, 2009, 46:278.
[18]	Che H C, Lihan S, Daria MR. Mitochondrial aldehyde dehydrogenase and cardiac diseases[J]. Cardiovascular Research,2010, 88:51.
[19]	Perez M, Samantha YH, Vanam R, et al. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant[J]. Nature Structural & Molecular Biology,2010, 17:159.
[20]	Matteo B, Antonius CF, Gorren M, et al. Characterization of the East Asian Variant of Aldehyde Dehydrogenase-2[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2010,285:943.
[21]	Grant RB, Marie HD, Daria MR. Aldehyde Dehydrogenase 2 in Cardiac Protection:A New Therapeutic Target[J]. TCM, 2009,19:159.
[22]	Samantha PM, Hina Y, Ram V, et al. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant[J]. Nature Structural & Molecular Biology, 2010,17:159.
[23]	Feldman RI, Weiner H. Horse liver aldehyde dehydrogenaseII Kinetics and mechanistic implications of the dehydrogenase and esterase activity[J]. J Biol Chem, 1972,5:267.
[24]	Takahashi K,Weiner W. Nicotinamide adenine dinucleotide activation of the esterase reaction of horse liver aldehyde dehydrogenase dehydrogenase[J].Biochemistry,1981,20:2720.
[25]	Mukerjee N,Pietruszko R. Human mitochondrial aldehyde dehydrogenase substrate specificity:comparison of esterase with dehydrogenase reaction[J]. Arch Biochem Biophys, 1992, 299:23.
[26]	Perez MS, Hurley TD. Coenzyme isomerization is integral to catalysis in human aldehyde dehydrogenase[J]. Biochemistry, 2003,42:7100.
[27]	Hammen PK, Allali HA, Hallenga K, et al. Multiple conformations of NAD and NADH when bound to human cytosolic and mitochondrial aldehyde dehydrogenase[J]. Biochemistry,2002,41:7156.
[28]	Suzuki Y, Ogawa S,Sakakibara Y. Chaperone therapy for neuronopathic lysosomal diseases:competitive inhibitors as chemical chaperones for enchancement of mutant enzyme activities[J]. Perspect Medicin Chem, 2009,3:7.
[29]	Lowe ED, Gao GY, Johnson LN,et al. Structure of daidzin, a naturally occurring anti-alcohol-addiction agent in complex with human mitochondrial aldehyde dehydrogenase[J]. J Med Chem,2008,51:4482.
[30]	Eun JC, Hak CK, Young CS, et al. Four Flavonoids from Echinosophora koreensis and their Effects on Alcohol Metabolizing Enzymes[J]. Arch Pharm Res, 2009, 32:851.
[31]	汤子春,邹坤,陆海华.开口箭与筒鞘蛇菰提取物醒酒作用机制的研究[J].时珍国医国药,2007,18:2958.

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Progress on Human aldehyde dehydrogenase II and its agonists

doi: 10.3969/j.issn.1006-0111.2013.02.004

Abstract

References

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通讯作者: 陈斌, bchen63@163.com

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