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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2013  >  31(1): 45-48

GAO Yanxia, SU Juan, JIN Huizi. Study on HPLC fingerprint of Ginseng Radix et Rhizoma Rubra[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 249-251,254. doi: 10.3969/j.issn.1006-0111.2016.03.014
Citation: JIN Rou-nan, LI Le-le, GONG Chun-gui. Analysis of serum bile acid changes in patient of oral administration of UDCA after hepatocellular carcinoma resection[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 45-48. doi: 10.3969/j.issn.1006-0111.2013.01.013
shu

Analysis of serum bile acid changes in patient of oral administration of UDCA after hepatocellular carcinoma resection

doi: 10.3969/j.issn.1006-0111.2013.01.013
  • 1.

    Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China

  • 2.

    Undergraduate of 2006 Grade, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2012-04-05
  • Rev Recd Date: 2012-06-20
  • Objective To analyze the serum bile acid changes in patient of oral administration of UDCA after hepatocellular carcinoma resection and provide reasonable recommendations for clinical staffs. Methods 89 cases with hepatocellular carcinoma after taking UDCA had been analyzed during 2009.01 to 2010.01. Results Serum bile acid concentration changes before medication of UDCA had been showed that the maximum value was 131.10 μmol/L, the minimum value was -69.00 μmol/L, quartile spacing was 15.30 μmol/L,and after medication, the maximum value was 275.20 μmol/L, the minimum value was -49.00 μmol/L, quartile spacing 30.50 μmol/L. The serum bile acid concentrations after medication of UDCA had increased significantly compared with the status before medication, P<0.01. The Child-Pugh scores before the medication of UDCA was correlated to the changes of serum bile acid after the medication of UDCA,P<0.01.The other variables, UDCA dosage, the amount of bleeding during operation, blocking time of portal vein, the different surgeon, cirrhosis were not correlated to the changes of serum bile acid after the medication of UDCA. Conclusion The Child-Pugh scores before the medication of UDCA should be the prime considerable factor as concerned.
  • [1] 唐海鸿,陈英杰,童光东,等.熊去氧胆酸联合通胆汤对原发性胆汁性肝硬化的治疗作用[J].世界华人消化杂志,2008,16(13):1417.
    [2] 陈文斌,潘祥林,康熙雄,等.诊断学[M].第6版.北京:人民卫生出版社,2004:401.
    [3] Tomomichi I,Kaoru I,Shuji K,et al.Protective effects of ursodeoxycholic acid on chenodeoxycholic acid-induced liver injury in hamsters[J]. World J Gastroenterol, 2007,13(37):5003.
    [4] 刘丽萍,贺承山.熊去氧胆酸治疗肝脏疾病的作用机制和临床应用进展[J].解放军药学学报,2004,20(4):283.
    [5] 李筱琳,王学强,葛秀林.熊去氧胆酸治疗淤胆型肝炎128例[J].实用医药杂志,2009,26(9):26.
    [6] 乔显微,董伟力,赵延玲.熊去氧胆酸胶囊治疗淤胆型肝炎64例临床疗效观察[J].实用医院临床杂志,2008,5(6):111.
    [7] La A,Ja C,Sa H.Effect of oral ursodeoxycholic acid on bile acids tolerance tests in healthy dogs[J]. Australian Veterinary J,2004,82(3):157.
    [8] 王 蓓,孙百军,李东华,等.中药利胆灵对胆色素结石患者引流胆汁中胆汁酸的影响[J].天津中医药,2007,24(2):110.
    [9] 代春江.熊去氧胆酸胶囊溶出度测定方法研究[J].中国药业,2008,17(7):19.
    [10] 罗生强,刘 钎,吉英杰,等.37例原发性胆汁性肝硬化的临床分析[J].药品评价,2007,4(5):352.
    [11] 陈建清,胡良凯,张建民.熊去氧胆酸在胆汁淤积性肝病中的应用[J].国际消化病杂志,2008,28(6):474.
    [12] 张学风,郭 辉.熊去氧胆酸胶囊治疗老年戊型淤胆型肝炎的临床观察[J].中国老年保健医学,2008,6(1):62.
    [13] Konno T,Tada K,Akamatsu K. Effect of dobutamine on serum bile acid levels in patients with cirrhosis[J].Current Therapeutic Research,1997,58(8):515.
    [14] 邵红征,李祥金.肝硬化患者血清总胆汁酸测定的临床意义[J].现代消化及介入诊疗,2009,14(3):193.
    [15] 石 旺,芦 琴.原发性肝癌病人血清总胆汁酸和转铁蛋白水平与Child分级的关系[J].中国基层医药,2004,11(5):600.
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    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 34.0 %其他: 34.0 %China: 0.3 %China: 0.3 %[]: 0.3 %[]: 0.3 %上海: 6.1 %上海: 6.1 %北京: 13.1 %北京: 13.1 %合肥: 0.3 %合肥: 0.3 %天津: 1.3 %天津: 1.3 %惠州: 0.3 %惠州: 0.3 %成都: 0.3 %成都: 0.3 %杭州: 0.6 %杭州: 0.6 %江门: 0.6 %江门: 0.6 %湖州: 0.3 %湖州: 0.3 %漳州: 0.3 %漳州: 0.3 %石家庄: 0.3 %石家庄: 0.3 %绥化: 0.3 %绥化: 0.3 %芒廷维尤: 21.2 %芒廷维尤: 21.2 %衡阳: 0.6 %衡阳: 0.6 %西宁: 16.3 %西宁: 16.3 %运城: 0.3 %运城: 0.3 %郑州: 0.3 %郑州: 0.3 %长沙: 1.9 %长沙: 1.9 %青岛: 0.6 %青岛: 0.6 %其他China[]上海北京合肥天津惠州成都杭州江门湖州漳州石家庄绥化芒廷维尤衡阳西宁运城郑州长沙青岛Highcharts.com
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Analysis of serum bile acid changes in patient of oral administration of UDCA after hepatocellular carcinoma resection

doi: 10.3969/j.issn.1006-0111.2013.01.013
  • 1. Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
  • 2. Undergraduate of 2006 Grade, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2012-04-05
  • Rev Recd Date: 2012-06-20

Abstract: Objective To analyze the serum bile acid changes in patient of oral administration of UDCA after hepatocellular carcinoma resection and provide reasonable recommendations for clinical staffs. Methods 89 cases with hepatocellular carcinoma after taking UDCA had been analyzed during 2009.01 to 2010.01. Results Serum bile acid concentration changes before medication of UDCA had been showed that the maximum value was 131.10 μmol/L, the minimum value was -69.00 μmol/L, quartile spacing was 15.30 μmol/L,and after medication, the maximum value was 275.20 μmol/L, the minimum value was -49.00 μmol/L, quartile spacing 30.50 μmol/L. The serum bile acid concentrations after medication of UDCA had increased significantly compared with the status before medication, P<0.01. The Child-Pugh scores before the medication of UDCA was correlated to the changes of serum bile acid after the medication of UDCA,P<0.01.The other variables, UDCA dosage, the amount of bleeding during operation, blocking time of portal vein, the different surgeon, cirrhosis were not correlated to the changes of serum bile acid after the medication of UDCA. Conclusion The Child-Pugh scores before the medication of UDCA should be the prime considerable factor as concerned.

GAO Yanxia, SU Juan, JIN Huizi. Study on HPLC fingerprint of Ginseng Radix et Rhizoma Rubra[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 249-251,254. doi: 10.3969/j.issn.1006-0111.2016.03.014
Citation: JIN Rou-nan, LI Le-le, GONG Chun-gui. Analysis of serum bile acid changes in patient of oral administration of UDCA after hepatocellular carcinoma resection[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 45-48. doi: 10.3969/j.issn.1006-0111.2013.01.013
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