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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2013  >  31(1): 45-48

SUN Guoquan, SHU Lixin, WANG Xiaojuan, CHEN Shengxin, YANG Zhangwei, LI Jiewei. Study on the use of antimicrobial agents in hospitalized trauma patients based on medical big data[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(5): 466-471. doi: 10.3969/j.issn.1006-0111.2017.05.021
Citation: JIN Rou-nan, LI Le-le, GONG Chun-gui. Analysis of serum bile acid changes in patient of oral administration of UDCA after hepatocellular carcinoma resection[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 45-48. doi: 10.3969/j.issn.1006-0111.2013.01.013
shu

Analysis of serum bile acid changes in patient of oral administration of UDCA after hepatocellular carcinoma resection

doi: 10.3969/j.issn.1006-0111.2013.01.013
  • 1.

    Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China

  • 2.

    Undergraduate of 2006 Grade, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2012-04-05
  • Rev Recd Date: 2012-06-20
  • Objective To analyze the serum bile acid changes in patient of oral administration of UDCA after hepatocellular carcinoma resection and provide reasonable recommendations for clinical staffs. Methods 89 cases with hepatocellular carcinoma after taking UDCA had been analyzed during 2009.01 to 2010.01. Results Serum bile acid concentration changes before medication of UDCA had been showed that the maximum value was 131.10 μmol/L, the minimum value was -69.00 μmol/L, quartile spacing was 15.30 μmol/L,and after medication, the maximum value was 275.20 μmol/L, the minimum value was -49.00 μmol/L, quartile spacing 30.50 μmol/L. The serum bile acid concentrations after medication of UDCA had increased significantly compared with the status before medication, P<0.01. The Child-Pugh scores before the medication of UDCA was correlated to the changes of serum bile acid after the medication of UDCA,P<0.01.The other variables, UDCA dosage, the amount of bleeding during operation, blocking time of portal vein, the different surgeon, cirrhosis were not correlated to the changes of serum bile acid after the medication of UDCA. Conclusion The Child-Pugh scores before the medication of UDCA should be the prime considerable factor as concerned.
  • [1] 唐海鸿,陈英杰,童光东,等.熊去氧胆酸联合通胆汤对原发性胆汁性肝硬化的治疗作用[J].世界华人消化杂志,2008,16(13):1417.
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    [12] 张学风,郭 辉.熊去氧胆酸胶囊治疗老年戊型淤胆型肝炎的临床观察[J].中国老年保健医学,2008,6(1):62.
    [13] Konno T,Tada K,Akamatsu K. Effect of dobutamine on serum bile acid levels in patients with cirrhosis[J].Current Therapeutic Research,1997,58(8):515.
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Analysis of serum bile acid changes in patient of oral administration of UDCA after hepatocellular carcinoma resection

doi: 10.3969/j.issn.1006-0111.2013.01.013
  • 1. Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
  • 2. Undergraduate of 2006 Grade, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2012-04-05
  • Rev Recd Date: 2012-06-20

Abstract: Objective To analyze the serum bile acid changes in patient of oral administration of UDCA after hepatocellular carcinoma resection and provide reasonable recommendations for clinical staffs. Methods 89 cases with hepatocellular carcinoma after taking UDCA had been analyzed during 2009.01 to 2010.01. Results Serum bile acid concentration changes before medication of UDCA had been showed that the maximum value was 131.10 μmol/L, the minimum value was -69.00 μmol/L, quartile spacing was 15.30 μmol/L,and after medication, the maximum value was 275.20 μmol/L, the minimum value was -49.00 μmol/L, quartile spacing 30.50 μmol/L. The serum bile acid concentrations after medication of UDCA had increased significantly compared with the status before medication, P<0.01. The Child-Pugh scores before the medication of UDCA was correlated to the changes of serum bile acid after the medication of UDCA,P<0.01.The other variables, UDCA dosage, the amount of bleeding during operation, blocking time of portal vein, the different surgeon, cirrhosis were not correlated to the changes of serum bile acid after the medication of UDCA. Conclusion The Child-Pugh scores before the medication of UDCA should be the prime considerable factor as concerned.

SUN Guoquan, SHU Lixin, WANG Xiaojuan, CHEN Shengxin, YANG Zhangwei, LI Jiewei. Study on the use of antimicrobial agents in hospitalized trauma patients based on medical big data[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(5): 466-471. doi: 10.3969/j.issn.1006-0111.2017.05.021
Citation: JIN Rou-nan, LI Le-le, GONG Chun-gui. Analysis of serum bile acid changes in patient of oral administration of UDCA after hepatocellular carcinoma resection[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 45-48. doi: 10.3969/j.issn.1006-0111.2013.01.013
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