白念珠菌的高适应性与代谢

毕爽; 胡丹丹; 姜远英; 王彦

doi:10.3969/j.issn.1006-0111.2016.02.006

白念珠菌的高适应性与代谢

doi: 10.3969/j.issn.1006-0111.2016.02.006

第二军医大学药学院新药研究中心, 上海 200433

基金项目: 国家自然科学基金(81273558),上海市浦江人才计划(14PJD001)

The high adaptability and metabolism of Candida albicans

New Drug Research and Development Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

摘要: 病原真菌白念珠菌对环境具有高度的适应能力,主要体现在与宿主共生时、侵袭宿主时以及在抗真菌药物作用的情况下。白念珠菌生存、繁殖的过程伴随着物质代谢,其可利用的碳源、氮源广泛,并且对营养物质的变化非常敏感。近年来不少研究发现,白念珠菌所处的环境会影响其代谢,与此同时,白念珠菌又可以通过调整代谢过程来适应多变的环境。因此,深入研究白念珠菌代谢与高适应性之间的关联有助于发现新的抗真菌作用靶点。
- 白念珠菌 /
- 高适应性 /
- 代谢
Abstract: Pathogenic Candida albicans has a high degree of adaptability to environment, which is evidenced by its adaptability to various conditions, including its symbiosis with the host, growth in host tissues during invasion, and survival under antifungal treatment. The growth and reproduction of C. albicans is accompanied with metabolism process. C. albicans can use a wide range of carbon and nitrogen sources, and it is sensitive to the alteration of nutrition. Recent studies reveal that the environment affects the metabolism of C. albicans, whilst C. albicans regulates its metabolism to adapt to the environment. Therefore, further study on the relationship between metabolism and high adaptability of C. albicans is helpful to discover novel antifungal targets.
- Candida albicans /
- high adaptability /
- metabolism

[1]	Guinea J. Global trends in the distribution of Candida species causing candidemia[J]. Clin Microbiol Infect, 2014, 20(Suppl 6):5-10.
[2]	Cottier F, Pavelka N. Complexity and dynamics of host-fungal interactions[J]. Immunol Res, 2012, 53(1-3):127-135.
[3]	Romani L, Zelante T, Palmieri M, et al. The cross-talk between opportunistic fungi and the mammalian host via microbiota's metabolism[J]. Semin Immunopathol, 2015, 37(2):163-171.
[4]	Mallick EM, Bennett RJ. Sensing of the microbial neighborhood by Candida albicans[J]. PLoS Pathog, 2013, 9(10):e1003661.
[5]	Staniszewska M, Bondaryk M, Pilat J, et al. Virulence factors of Candida albicans[J]. Przegl Epidemiol, 2012, 66(4):629-633.
[6]	Zhu W, Filler S G. Interactions of Candida albicans with epithelial cells[J]. Cell Microbiol, 2010, 12(3):273-282.
[7]	Hoyer LL. The ALS gene family of Candida albicans[J]. Trends Microbiol, 2001, 9(4):176-180.
[8]	Sun N, Fonzi W, Chen H, et al. Azole susceptibility and transcriptome profiling in Candida albicans mitochondrial electron transport chain complex I mutants[J]. Antimicrob Agents Chemother, 2013, 57(1):532-542.
[9]	Prasad R, Rawal MK. Efflux pump proteins in antifungal resistance[J]. Front Pharmacol, 2014, 5:202.
[10]	Ene IV, Adya AK, Wehmeier S, et al. Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen[J]. Cell Microbiol, 2012, 14(9):1319-1335.
[11]	Lorenz MC, Fink GR. The glyoxylate cycle is required for fungal virulence[J]. Nature, 2001, 412(6842):83-86.
[12]	Cheah HL, Lim V, Sandai D. Inhibitors of the glyoxylate cycle enzyme ICL1 in Candida albicans for potential use as antifungal agents[J]. PLoS One, 2014, 9(4):e95951.
[13]	Kemsawasd V, Viana T, Ardo Y, et al. Influence of nitrogen sources on growth and fermentation performance of different wine yeast species during alcoholic fermentation[J]. Appl Microbiol Biotechnol, 2015.
[14]	Gagiano M, Bauer F-F, Pretorius IS. The sensing of nutritional status and the relationship to filamentous growth in Saccharomyces cerevisiae[J]. FEMS Yeast Res, 2002, 2(4):433-470.
[15]	Buu LM, Chen YC. Impact of glucose levels on expression of hypha-associated secreted aspartyl proteinases in Candida albicans[J]. J Biomed Sci, 2014, 21:22.
[16]	Han TL, Cannon RD, Villas-B? as S-G. The metabolic basis of Candida albicans morphogenesis and quorum sensing[J]. Fungal Genet Biol, 2011, 48(8):747-763.
[17]	Brown AJ, Brown GD, Netea MG, et al. Metabolism impacts upon Candida immunogenicity and pathogenicity at multiple levels[J]. Trends Microbiol, 2014, 22(11):614-622.
[18]	Vieira N, Casal M, Johansson B, et al. Functional specialization and differential regulation of short-chain carboxylic acid transporters in the pathogen Candida albicans[J]. Mol Microbiol, 2010, 75(6):1337-1354.
[19]	Kitahara N, Morisaka H, Aoki W, et al. Description of the interaction between Candida albicans and macrophages by mixed and quantitative proteome analysis without isolation[J]. Amb Express, 2015, 5(1):127.
[20]	Ramirez MA, Lorenz MC. Mutations in alternative carbon utilization pathways in Candida albicans attenuate virulence and confer pleiotropic phenotypes[J]. Eukaryot Cell, 2007, 6(2):280-290.
[21]	Sellam A, van het Hoog M, Tebbji F, et al. Modeling the transcriptional regulatory network that controls the early hypoxic response in Candida albicans[J]. Eukaryot Cell, 2014, 13(5):675-690.
[22]	Dunkel N, Biswas K, Hiller E, et al. Control of morphogenesis, protease secretion and gene expression in Candida albicans by the preferred nitrogen source ammonium[J]. Microbiology, 2014, 160(Pt 8):1599-1608.
[23]	Ramachandra S, Linde J, Brock M, et al. Regulatory networks controlling nitrogen sensing and uptake in Candida albicans[J]. PLoS One, 2014, 9(3):e92734.
[24]	Yan L, Zhang JD, Cao YB, et al. Proteomic analysis reveals a metabolism shift in a laboratory fluconazole-resistant Candida albicans strain[J]. J Proteome Res, 2007, 6(6):2248-2256.
[25]	Xu Y, Sheng F, Zhao J, et al. ERG11 mutations and expression of resistance genes in fluconazole-resistant Candida albicans isolates[J]. Arch Microbiol, 2015.

[1]	杨嘉宁, 赵一颖, 肖伟. 七味脂肝方对非酒精性脂肪性肝炎动物模型的药效学评价 . 药学实践与服务, 2024, 42(9): 389-398. doi: 10.12206/j.issn.2097-2024.202404096
[2]	唐淑慧, 凤美娟, 薛智霞, 鲁桂华. 帕博利珠单抗治疗所致免疫相关不良反应与中医体质的相关性研究 . 药学实践与服务, 2024, 42(5): 217-222. doi: 10.12206/j.issn.2097-2024.202311029
[3]	桂明珠, 李静, 李志玲. 儿童伏立康唑的血药浓度与CYP2C19、CYP2C9和CYP3A5基因多态性的相关性研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202402020
[4]	王耀振, 徐灿, 吕顺莉, 田泾, 张东炜. 钾离子竞争性酸阻滞剂的药学特征研究进展 . 药学实践与服务, 2024, 42(7): 278-284. doi: 10.12206/j.issn.2097-2024.202306040
[5]	张晶晶, 索丽娜, 郑兆红. 89例细菌性肝脓肿的临床特征及抗感染治疗分析 . 药学实践与服务, 2024, 42(6): 267-272. doi: 10.12206/j.issn.2097-2024.202302039
[6]	刘丽艳, 余小翠, 孙传铎. 纳武利尤单抗治疗非小细胞肺癌有效性及安全性的Meta分析 . 药学实践与服务, 2024, 42(10): 451-456. doi: 10.12206/j.issn.2097-2024.202310044
[7]	张艺昕, 关欣怡, 王博宁, 闻俊, 洪战英. 二氢吡啶类钙离子拮抗药物手性分析及其立体选择性药动学研究进展 . 药学实践与服务, 2024, 42(8): 319-324. doi: 10.12206/j.issn.2097-2024.202308062
[8]	徐飞, 陈瑾, 鲁育含, 李志勇. 肠道菌群参与糖尿病肾病的机制研究进展 . 药学实践与服务, 2024, 42(5): 181-184, 197. doi: 10.12206/j.issn.2097-2024.202312023
[9]	黄韵, 张正银, 金英, 郑怡菁, 李铁军, 孙莉莉. 耐碳青霉烯类肺炎克雷伯菌及大肠埃希菌临床分离株耐药性及耐药基因分析 . 药学实践与服务, 2024, 42(10): 439-444. doi: 10.12206/j.issn.2097-2024.202309059
[10]	尹小娟, 台力丽, 肖俊峰, 季波. 铜绿假单胞菌合并按蚊伊丽莎白菌肺部感染的病例分析 . 药学实践与服务, 2024, 42(5): 223-226. doi: 10.12206/j.issn.2097-2024.202310042
[11]	戴菲菲, 傅翔, 陈琼年, 俞苏纯. 上海某二级医院革兰阴性菌流行特征的回顾性分析 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202305005
[12]	毛智毅, 王筱燕, 陈晓颖, 汤逸斐. 度拉糖肽联合二甲双胍对肥胖型2型糖尿病患者机体代谢、体脂成分及血清脂肪因子的影响 . 药学实践与服务, 2024, 42(7): 305-309. doi: 10.12206/j.issn.2097-2024.202305032
[13]	迟文雅, 袁艳, 李伟林, 吴茼妤, 俞媛. 负载骨髓间充质干细胞/白藜芦醇脂质体的水凝胶支架用于创伤性脑损伤治疗 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202406034
[14]	郭灵怡, 刘艳超, 高路, 刘瑞瑶, 吕权真, 俞媛. 醋酸卡泊芬净单硬脂酸甘油酯纳米粒抗白色念珠菌感染的增效作用研究 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202310043
[15]	史生辉, 石飞, 雷琼, 王亚峰, 吴雪花. 青藏高原肺结核合并念珠菌感染患者的病原菌分布特点及耐药率分析 . 药学实践与服务, 2024, 42(6): 260-262, 272. doi: 10.12206/j.issn.2097-2024.202304014
[16]	孙丹倪, 黄勇, 张嘉宝, 王培. 代谢相关脂肪性肝病的无创诊断与药物治疗 . 药学实践与服务, 2024, 42(10): 411-418. doi: 10.12206/j.issn.2097-2024.202403049

点击查看大图

计量

文章访问数: 5052
HTML全文浏览量: 466
PDF下载量: 32
被引次数: 0

姓名
邮箱
手机号码
标题
留言内容
验证码

留言板

白念珠菌的高适应性与代谢

doi: 10.3969/j.issn.1006-0111.2016.02.006

The high adaptability and metabolism of Candida albicans

计量

白念珠菌的高适应性与代谢

doi: 10.3969/j.issn.1006-0111.2016.02.006

第二军医大学药学院新药研究中心, 上海 200433

English Abstract

The high adaptability and metabolism of Candida albicans

New Drug Research and Development Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

全文HTML

目录

留言板

白念珠菌的高适应性与代谢

doi: 10.3969/j.issn.1006-0111.2016.02.006

The high adaptability and metabolism of Candida albicans

计量

出版历程

白念珠菌的高适应性与代谢

doi: 10.3969/j.issn.1006-0111.2016.02.006

第二军医大学药学院新药研究中心, 上海 200433

English Abstract

The high adaptability and metabolism of Candida albicans

New Drug Research and Development Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

全文HTML

目录