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两性霉素B联合用药的研究进展

赵柳娅 曹颖瑛 姜远英

赵柳娅, 曹颖瑛, 姜远英. 两性霉素B联合用药的研究进展[J]. 药学实践与服务, 2014, 32(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2014.01.001
引用本文: 赵柳娅, 曹颖瑛, 姜远英. 两性霉素B联合用药的研究进展[J]. 药学实践与服务, 2014, 32(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2014.01.001
ZHAO Liuya, CAO Yingying, JIANG Yuanying. Research progress in the combined use of amphotericin B[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2014.01.001
Citation: ZHAO Liuya, CAO Yingying, JIANG Yuanying. Research progress in the combined use of amphotericin B[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2014.01.001

两性霉素B联合用药的研究进展

doi: 10.3969/j.issn.1006-0111.2014.01.001

Research progress in the combined use of amphotericin B

  • 摘要: 两性霉素B(amphotericin B,AmB)属于多烯类抗真菌药物,因其耐药率低、抗菌谱广,被称为治疗深部真菌感染的"金标准",但是严重的毒副作用(尤其是肾毒性)大大限制了AmB在临床上的应用。在目前高效、低毒的抗真菌药物较少的情况下,联合使用不同作用机制的抗真菌药物,使其发挥协同作用,缩短疗程、减少药物毒副作用、扩大药物抗菌谱、避免耐药性的出现,是当前深部真菌感染治疗研究领域的一个重要研究方向。本文对AmB与不同种类抗真菌药物联合使用的研究进展作一综述。
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    [18] Jon AO, Adler-Moore JP, Smith PJ, et al. Treatment of Candida glabrata infection in immunosuppressed mice by using a combination of liposomal amphotericin B with caspofungin or micafungin[J]. Antimicrob Agents Chemother,2005, 49 (12):4895-4902.
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两性霉素B联合用药的研究进展

doi: 10.3969/j.issn.1006-0111.2014.01.001

摘要: 两性霉素B(amphotericin B,AmB)属于多烯类抗真菌药物,因其耐药率低、抗菌谱广,被称为治疗深部真菌感染的"金标准",但是严重的毒副作用(尤其是肾毒性)大大限制了AmB在临床上的应用。在目前高效、低毒的抗真菌药物较少的情况下,联合使用不同作用机制的抗真菌药物,使其发挥协同作用,缩短疗程、减少药物毒副作用、扩大药物抗菌谱、避免耐药性的出现,是当前深部真菌感染治疗研究领域的一个重要研究方向。本文对AmB与不同种类抗真菌药物联合使用的研究进展作一综述。

English Abstract

赵柳娅, 曹颖瑛, 姜远英. 两性霉素B联合用药的研究进展[J]. 药学实践与服务, 2014, 32(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2014.01.001
引用本文: 赵柳娅, 曹颖瑛, 姜远英. 两性霉素B联合用药的研究进展[J]. 药学实践与服务, 2014, 32(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2014.01.001
ZHAO Liuya, CAO Yingying, JIANG Yuanying. Research progress in the combined use of amphotericin B[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2014.01.001
Citation: ZHAO Liuya, CAO Yingying, JIANG Yuanying. Research progress in the combined use of amphotericin B[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2014.01.001
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