留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码
x 关闭 永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

抑郁症致病机制及中药治疗抑郁症的机制研究

姚媛,  周艺,  周婷婷

downloadPDF
文章导航 > 药学实践与服务  > 2018 >  36(3): 193-197
姚媛, 周艺, 周婷婷. 抑郁症致病机制及中药治疗抑郁症的机制研究[J]. 药学实践与服务, 2018, 36(3): 193-197. doi: 10.3969/j.issn.1006-0111.2018.03.001
引用本文: 姚媛, 周艺, 周婷婷. 抑郁症致病机制及中药治疗抑郁症的机制研究[J]. 药学实践与服务, 2018, 36(3): 193-197. doi: 10.3969/j.issn.1006-0111.2018.03.001
shu
YAO Yuan, ZHOU Yi, ZHOU Tingting. Pathogenesis of depression and the mechanism research in TCM treatment of major depression[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 193-197. doi: 10.3969/j.issn.1006-0111.2018.03.001
Citation: YAO Yuan, ZHOU Yi, ZHOU Tingting. Pathogenesis of depression and the mechanism research in TCM treatment of major depression[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 193-197. doi: 10.3969/j.issn.1006-0111.2018.03.001
shu

抑郁症致病机制及中药治疗抑郁症的机制研究

doi: 10.3969/j.issn.1006-0111.2018.03.001
  • 1.

    安徽中医药大学药学院, 安徽 合肥 230012;第二军医大学药学院, 上海 200433;上海市药物(中药)代谢产物研究重点实验室, 上海 200433

  • 2.

    94826部队医院内科, 上海 200433

  • 3.

    第二军医大学药学院, 上海 200433;上海市药物(中药)代谢产物研究重点实验室, 上海 200433

基金项目: 国家自然科学基金资助项目（81573584，81773862）

Pathogenesis of depression and the mechanism research in TCM treatment of major depression

  • 1.

    School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China;Shanghai Key Laboratory for Pharmaceutical Metabolites Research, Shanghai 200433, China

  • 2.

    Medical Department of 94826 Military Hospital, Shanghai 200433, China

  • 3.

    School of Pharmacy, Second Military Medical University, Shanghai 200433, China;Shanghai Key Laboratory for Pharmaceutical Metabolites Research, Shanghai 200433, China

  • 摘要: 抑郁症严重危害人类身心健康，世界卫生组织预测：2020年抑郁症将成为非正常死亡和残疾的第二大原因。目前临床上大多使用三环类抗抑郁药（TCA）、四环类抗抑郁药、选择性5-HT再摄取抑制药等来治疗抑郁症，但长期应用这类药物易产生耐药性，不良反应明显，且这种通过单一成分阻断特定单一靶点的药物，对于涉及体内多个系统的生物学异常往往难以达到治疗效果。中药组方通过其所包含的多组分能同时调节多靶点、调节疾病网络的多个环节，在获得较高疗效的同时可降低化学药单靶点引起的毒副作用，且目前国内外对一些传统中药抗抑郁作用机制的研究报道也日渐增多，主要集中在神经递质水平释放、海马脑源性神经营养因子（BDNF）表达及细胞因子等方面。此外，最新的研究认为肠道菌群可能参与了从情感性疾病到神经系统疾病的发生发展。综述近年来中药抗抑郁神经保护作用的机制研究进展，以期为抑郁症发病机制探讨及抗抑郁药物研究提供借鉴和指导。
    Abstract: Depression is a serious health hazard and the World Health Organization predicts that depression will be the second leading cause of abnormal death and disability by 2020. Currently, most antidepressants are tricyclic antidepressants (TCA), tetracyclic antidepressants and selective 5-HT reuptake inhibitors. Long term use of those medications will develop resistance and adverse reactions. In addition, drugs that block a single target are often hard to achieve therapeutic outcomes due to the biological abnormalities involving multiple systems in the body. Traditional Chinese Medicine (TCM) can simultaneously act on multiple targets to influence the disease network in many aspects at the same time. This approach has higher efficacy and lower side effects than a single chemical medication. Recently, there are increasing numbers of research papers on antidepressant mechanism of TMC, mainly focused on the release level of neurotransmitters, hippocampus brain derived neurotrophic factor (BDNF) expression and cytokines, etc. The latest researches also indicated that the gut microbiota has involved the development of emotional diseases and the diseases related to central nerves system. This paper reviews the mechanism studies of TMC as antidepressants and neuroprotection agents in order to shed new light on the study of depression pathogenesis and development of new antidepressant medications.
  • [1] Sayers J. The world health report 2001-Mental health:new understanding,new hope[J]. Bullet World Health Organ,2001,79(11):1085.
    [2] Zhang X, Tian JS, Liu H, et al. Progress of new antidepressant drugs development[J]. Chin J Chin Mater Medic, 2017, 42(1):29-33.
    [3] 王旭东, 乔明琦, 张樟进,等. 中医药治疗抑郁症的研究进展[J]. 南京中医药大学学报, 2016, 32(1):93-96.
    [4] Adam Samuels B, Leonardo ED, Hen R. Hippocampal subfields and major depressive disorder[J]. Biol Psychiatry, 2015, 77(3):210-211.
    [5] Schoenfeld TJ, Mccausland HC, Morris HD, et al. Stress and loss of adult nurogenesis differentially reduce hippocampal volume[J]. Bioll Psychiatry, 2017,82(12):914-923.
    [6] Hill AS, Sahay A, Hen R. Increasing adult hippocampal neurogenesis is sufficient to reduce anxiety and depression-like behaviors[J]. Neuropsychopharmacology, 2015, 40(10):2368-2378.
    [7] Bremner JD, Narayan M, Anderson ER, et al. Hippocampal volume reduction in major depression[J]. Am J Psychiatry, 2000, 157(1):115-118.
    [8] Moraitis AG, Block T, Nguyen D, et al. The role of glucocorticoid receptors in metabolic syndrome and psychiatric illness[J]. J Steroid Biochem Mol Biol, 2017, 165:114-120.
    [9] 张国双, 杨坤. 抗抑郁新靶点-糖皮质激素受体[J]. 国际精神病学杂志, 2015,42(1):84-86.
    [10] Kinlein SA, Wilson CD, Karatsoreos IN. Dysregulated hypothalamic-pituitary-adrenal axis function contributes to altered endocrine and neurobehavioral responses to acute stress[J]. Front Psychiatry, 2015, 6:31.
    [11] Ferrari F, Villa RF. The neurobiology of depression:an integrated overview from biological theories to clinical evidence[J]. Mol Neurobiol,2017,54(7):4847-4865.
    [12] 乔卉, 安书成, 徐畅. BDNF与抑郁症的研究现状及进展[J]. 生理科学进展, 2011, 42(3):195-200.
    [13] Rantamaki T, Yalcin I. Antidepressant drug action-from rapid changes on network function to network rewiring[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2016, 64:285-292.
    [14] Schmitt K, Holsboer-Trachsler E, Eckert A. BDNF in sleep, insomnia, and sleep deprivation[J]. Ann Med, 2016, 48(1-2):42-51.
    [15] Hauser SR, Getachew B, Taylor RE, et al. Alcohol induced depressive-like behavior is associated with a reduction in hippocampal BDNF[J]. Pharmacol Biochem Behav, 2011, 100(2):253-258.
    [16] Zhuang F, Zhou X, Gao X, et al. Cytokines and glucocorticoid receptors are associated with the antidepressant-like effect of alarin[J]. Peptides, 2016, 76:115-129.
    [17] Felger JC, Lotrich FE. Inflammatory cytokines in depression:neurobiological mechanisms and therapeutic implications[J]. Neuroscience, 2013, 246(5):199-229.
    [18] Su WJ, Cao ZY, Jiang CL. Inflammatory mechanism of depression and its new strategy for diagnosis and treatment[J].Sheng Li Xue Bao,2017,69(5):715-722.
    [19] 汪崇泽, 盛国红. 免疫炎症途径与抑郁症的研究进展[J]. 精神医学杂志, 2015,28(5):397-400.
    [20] Zhu X, Han Y, Du J, et al. Microbiota-gut-brain axis and the central nervous system[J]. Oncotarget, 2017, 8(32):53829-53838.
    [21] 于林, 胡号应, 丁国安,等. 肠道微生物在抑郁症发病中的作用及其研究进展[C].2016中华中医药学会神志病分会学术年会,2016.
    [22] Zheng P, Zeng B, Zhou C, et al. Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism[J]. Mol Psychiatry, 2016, 21(6):786-796.
    [23] Zhang QX,Ma XL,Yang Y, et al. Jieyuanshen decoction exerts antidepressant effects on depressive rat model via regulating hpa axis and the level of amino acids neurotransmitter[J]. Afric J Tradit,Complement Altern Med,2017, 14(2):33-46.
    [24] 刘婉婉, 许璐, 董宪喆,等. 开心散类方对慢性应激大鼠行为学及中枢单胺类神经递质的影响[J]. 中国中药杂志, 2015, 40(11):2180-2185.
    [25] Dong XZ, Li ZL, Zheng XL, et al. A representative prescription for emotional disease, Ding-Zhi-Xiao-Wan restores 5-HT system deficit through interfering the synthesis and transshipment in chronic mild stress-induced depressive rats[J]. J Ethnopharmacol, 2013, 150(3):1053-1061.
    [26] Gong MJ, Han B, Wang SM, et al. Icariin reverses corticosterone-induced depression-like behavior, decrease in hippocampal brain-derived neurotrophic factor (BDNF) and metabolic network disturbances revealed by NMR-based metabonomics in rats[J]. J Pharm Biomed Anal, 2016, 123:63-73.
    [27] Ye YL,Zhong K, Liu DD, et al. Huanglian-Jie-Du-Tang extract ameliorates depression-like behaviors through BDNF-TrkB-CREB pathway in rats with chronic unpredictable stress[J]. Evidence-Based Complement Altern Med,2017(4):1-13.
    [28] Chen CY, Yeh YW, Kuo SC, et al. Differences in immunomodulatory properties between venlafaxine and paroxetine in patients with major depressive disorder[J]. Psychoneuroendocrinology, 2017, 87:108-118.
    [29] An L, Li J,Yu ST, et al. Effects of the total flavonoid extract of Xiao bu xin-Tang on depression-like behavior induced by lipopolysaccharide and proinflammatory cytokine levels in mice[J]. J Ethnopharmacol, 2015, 163:83-87.
    [30] Qiu JJ, Liu Z, Zhao P, et al. Gut microbial diversity analysis using Illumina sequencing for functional dyspepsia with liver depression-spleen deficiency syndrome and the interventional Xiaoyaosan in a rat model[J]. World J Gastroenterol, 2017, 23(5):810-816.
  • [1] 毛智毅, 王筱燕, 陈晓颖, 汤逸斐.  度拉糖肽联合二甲双胍对肥胖型2型糖尿病患者机体代谢、体脂成分及血清脂肪因子的影响 . 药学实践与服务, 2024, 42(7): 305-309. doi: 10.12206/j.issn.2097-2024.202305032
    [2] 张广雨, 杜晶, 刘梦珍, 朱丹妮, 闫慧, 刘冲.  新斯的明与山莨菪碱联合应用对肺型氧中毒的保护作用及其机制的研究 . 药学实践与服务, 2024, 42(10): 433-438, 444. doi: 10.12206/j.issn.2097-2024.202310049
    [3] 陈静, 何瑞华, 翁月, 徐熠, 刘静, 黄瑾.  基于网络药理学和分子对接技术探究定清片活性成分治疗白血病的作用机制 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202401073
    [4] 修建平, 杨朝爱, 刘禧澳, 潘乾禹, 韦广旭, 王卫星.  全反式维甲酸对肝星状细胞活化及氧化应激的作用和机制探索 . 药学实践与服务, 2024, 42(7): 291-296. doi: 10.12206/j.issn.2097-2024.202312054
    [5] 姜涛, 徐卫凡, 蒋益萍, 夏天爽, 辛海量.  巴戟天丸组方对Aβ损伤成骨细胞的作用及基于网络药理学的机制研究 . 药学实践与服务, 2024, 42(7): 285-290, 296. doi: 10.12206/j.issn.2097-2024.202305011
    [6] 杨彬, 王作君, 陈菡, 张敬一.  基于DRGs的医院合理用药管理机制探索实践 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202404030
    [7] 李清, 郭宜银, 陈颖, 瞿发林, 董文燊, 戈煜.  夜宁胶囊对小鼠镇静催眠作用及其机制的研究 . 药学实践与服务, 2024, 42(8): 346-349. doi: 10.12206/j.issn.2097-2024.202211047
    [8] 徐飞, 陈瑾, 鲁育含, 李志勇.  肠道菌群参与糖尿病肾病的机制研究进展 . 药学实践与服务, 2024, 42(5): 181-184, 197. doi: 10.12206/j.issn.2097-2024.202312023
    [9] 夏哲炜, 曾垣烨, 朱海菲, 李育, 陈啸飞.  核磁共振磷谱法测定磷酸氢钙咀嚼片中药物含量 . 药学实践与服务, 2024, 42(9): 399-401, 406. doi: 10.12206/j.issn.2097-2024.202404063
    [10] 景凯, 杨慈荣, 张圳, 臧艺蓓, 刘霞.  黄芪甲苷衍生物治疗慢性心力衰竭小鼠的药效评价及作用机制研究 . 药学实践与服务, 2024, 42(5): 190-197. doi: 10.12206/j.issn.2097-2024.202310004
    [11] 钱淑雨, 李铁军.  耐碳青霉烯类肠杆菌耐药机制的研究进展 . 药学实践与服务, 2024, 42(10): 419-425. doi: 10.12206/j.issn.2097-2024.202405005
    [12] 赖立勇, 夏天爽, 徐圣焱, 蒋益萍, 岳小强, 辛海量.  中药青蒿抗氧化活性的谱效关系研究 . 药学实践与服务, 2024, 42(5): 203-210, 216. doi: 10.12206/j.issn.2097-2024.202211012
    [13] 陈莹, 许子华, 胡北, 崔亚玲, 高欢, 吴琼.  通便灵胶囊治疗便秘的药效与机制研究 . 药学实践与服务, 2024, 42(): 1-7. doi: 10.12206/j.issn.2097-2024.202404008
    [14] 岳春华, 贲永光, 王海桥.  基于NLRP1炎症小体探讨百合知母汤抗抑郁的作用机制 . 药学实践与服务, 2024, 42(8): 325-333. doi: 10.12206/j.issn.2097-2024.202401033
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  5496
  • HTML全文浏览量:  788
  • PDF下载量:  881
  • 被引次数: 0
出版历程
  • 收稿日期:  2017-12-19
  • 修回日期:  2018-01-22

抑郁症致病机制及中药治疗抑郁症的机制研究

doi: 10.3969/j.issn.1006-0111.2018.03.001
  • 1. 安徽中医药大学药学院, 安徽 合肥 230012;第二军医大学药学院, 上海 200433;上海市药物(中药)代谢产物研究重点实验室, 上海 200433
  • 2. 94826部队医院内科, 上海 200433
  • 3. 第二军医大学药学院, 上海 200433;上海市药物(中药)代谢产物研究重点实验室, 上海 200433
    • 基金项目:  国家自然科学基金资助项目（81573584，81773862）
  • 收稿日期: 2017-12-19
  • 修回日期: 2018-01-22

摘要: 抑郁症严重危害人类身心健康，世界卫生组织预测：2020年抑郁症将成为非正常死亡和残疾的第二大原因。目前临床上大多使用三环类抗抑郁药（TCA）、四环类抗抑郁药、选择性5-HT再摄取抑制药等来治疗抑郁症，但长期应用这类药物易产生耐药性，不良反应明显，且这种通过单一成分阻断特定单一靶点的药物，对于涉及体内多个系统的生物学异常往往难以达到治疗效果。中药组方通过其所包含的多组分能同时调节多靶点、调节疾病网络的多个环节，在获得较高疗效的同时可降低化学药单靶点引起的毒副作用，且目前国内外对一些传统中药抗抑郁作用机制的研究报道也日渐增多，主要集中在神经递质水平释放、海马脑源性神经营养因子（BDNF）表达及细胞因子等方面。此外，最新的研究认为肠道菌群可能参与了从情感性疾病到神经系统疾病的发生发展。综述近年来中药抗抑郁神经保护作用的机制研究进展，以期为抑郁症发病机制探讨及抗抑郁药物研究提供借鉴和指导。

English Abstract

姚媛, 周艺, 周婷婷. 抑郁症致病机制及中药治疗抑郁症的机制研究[J]. 药学实践与服务, 2018, 36(3): 193-197. doi: 10.3969/j.issn.1006-0111.2018.03.001
引用本文: 姚媛, 周艺, 周婷婷. 抑郁症致病机制及中药治疗抑郁症的机制研究[J]. 药学实践与服务, 2018, 36(3): 193-197. doi: 10.3969/j.issn.1006-0111.2018.03.001
shu
YAO Yuan, ZHOU Yi, ZHOU Tingting. Pathogenesis of depression and the mechanism research in TCM treatment of major depression[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 193-197. doi: 10.3969/j.issn.1006-0111.2018.03.001
Citation: YAO Yuan, ZHOU Yi, ZHOU Tingting. Pathogenesis of depression and the mechanism research in TCM treatment of major depression[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 193-197. doi: 10.3969/j.issn.1006-0111.2018.03.001
shu

    全文HTML

参考文献 (30)

目录

    /

    返回文章
    返回

    版权所有：《药学实践与服务》编辑委员会

    主管、主办: 中国人民解放军海军军医大学地址: 上海市杨浦区国和路325号邮政编码: 200433

    电话: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计