留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码
x 关闭 永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

基于疾病动物模型的中药药动学研究进展

王韵,  柴逸峰,  朱臻宇

downloadPDF
文章导航 > 药学实践与服务  > 2017 >  35(2): 108-111,140
王韵, 柴逸峰, 朱臻宇. 基于疾病动物模型的中药药动学研究进展[J]. 药学实践与服务, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003
引用本文: 王韵, 柴逸峰, 朱臻宇. 基于疾病动物模型的中药药动学研究进展[J]. 药学实践与服务, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003
shu
WANG Yun, CHAI Yifeng, ZHU Zhenyu. Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003
Citation: WANG Yun, CHAI Yifeng, ZHU Zhenyu. Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003
shu

基于疾病动物模型的中药药动学研究进展

doi: 10.3969/j.issn.1006-0111.2017.02.003

  • 第二军医大学药学院药物分析学教研室, 上海 200433

基金项目: 国家自然科学基金资助项目（81273472， 81573396）

Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states

  • Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 摘要: 中药药动学是中药现代化研究必不可少的环节，是中医药与世界接轨的重要手段。药物在作用部位只有达到足够浓度，才能在体内发挥药效，而药物浓度不仅与给药剂量有关，亦受到药物体内过程的影响。传统中药药动学研究多基于健康实验动物展开，忽视了疾病状态下生理和病理变化可能引起相关药动学参数显著改变。本文系统综述了近年来基于常见疾病动物模型开展的中药药动学比较研究，并对不同动物模型药动学比较的研究发展趋势进行讨论和展望。
    Abstract: In recent years, pharmacokinetics of traditional Chinese medicine has become essential for the modernization of traditional Chinese medicine. Pharmacokinetics is an important means for connecting traditional Chinese medicine with western medicine. Medications exert efficacy only when there is sufficient concentration at the target sites. The drug concentration is not only related to the dosage, but is also closely correlated to the metabolic processes in human body. Most pharmacokinetic studies of traditional Chinese medicine are based on healthy animals, which ignore significant changes of pharmacokinetic parameters in the diseased state. In this paper, the comparative pharmacokinetics of the traditional Chinese medicine based on animal models in their diseased states was reviewed. Developmental trends of pharmacokinetics of traditional Chinese medicine with different animal models were also discussed.
  • [1] 郭涛. 新编药物动力学[M]. 北京:中国科学技术出版社,2005:338.
    [2] Xu B, Li P, Zhang G. Comparative pharmacokinetics of puerarin, daidzin, baicalin, glycyrrhizic acid, liquiritin, berberine, palmatine and jateorhizine by liquid chromatography-mass spectrometry after oral administration of Gegenqinlian decoction and active components alignment (ACA) to rats[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2015, 988:33-44.
    [3] Chen Y, Li Y, Wang Y, et al. Comparative pharmacokinetics of active alkaloids after oral administration of Rhizoma Coptidis extract and Wuji Wan formulas in rat using a UPLC-MS/MS method[J]. Eur J Drug Metab Pharmacokinet, 2015, 40(1):67-74.
    [4] Liu Y, Wang D, Yang G, et al. Comparative pharmacokinetics and brain distribution of magnolol and honokiol after oral administration of Magnolia officinalis cortex extract and its compatibility with other herbal medicines in Zhi-Zi-Hou-Po Decoction to rats[J]. Biomed Chromatogr:BMC, 2015, 30(3):369-375.
    [5] Xie JT, Wang A, Mehendale S, et al. Anti-diabetic effects of Gymnema yunnanense extract[J]. Pharmacol Res, 2003, 47(4):323-329.
    [6] Feng Y, Liu Z, Peng Y, et al. Validated LC-MS method for simultaneous quantitation of catalpol and harpagide in rat plasma:application to a comparative pharmacokinetic study in normal and diabetic rats after oral administration of Zeng-Ye-Decoction[J]. Biomed Chromatogr:BMC, 2013, 27(11):1503-1510.
    [7] He LH, Li J, Deng YX, et al. Comparative investigation on the pharmacokinetics of geniposide in type 2 diabetic and normal rats after oral administration of Fructus Gradeniae extract[J]. J Chromatogr B Analyt Technol BiomedLife Sci, 2016, 1033:180-186.
    [8] 袁铭兰,田玉芳, 孙晨. 苦荞提取物中槲皮素在糖尿病大鼠体内的药动学研究[J]. 中华灾害救援医学, 2015, 3(8):445-449.
    [9] 范惠霞,邓志鹏,王福文,等. 刺五加注射液在正常大鼠与脑缺血-再灌注损伤疾病大鼠体内药动学比较[J]. 中成药, 2015, 37(6):1215-1221.
    [10] 邵明晶,冯芳. 蒽醌在正常及酒精肝损伤大鼠的药动学比较[J]. 广州化工, 2015, 43(6):53-56.
    [11] Yang T, Liu S, Wang CH, et al. Comparative pharmacokinetic and tissue distribution profiles of four major bioactive components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe[J]. J Pharm Biomed Anal, 2015, 114:152-158.
    [12] Yang T, Liu S, Zheng TH, et al. Comparative pharmacokinetics and tissue distribution profiles of lignan components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe[J]. J Ethnopharmacol, 2015, 166:305-312.
    [13] Zhu H, Bi K, Han F, et al. Simultaneous determination of two iridoid glycosides, two anthraquinones and four flavonoid glycosides of Zhi-Zi-Da-Huang decoction in rat plasma by UFLC-MS/MS:application to a comparative pharmacokinetic study in normal and cholestatic liver injury rats[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2014, 960:116-125.
    [14] Liu R, Ma R, Yu C, et al. Quantitation of eleven active compounds of Aidi injection in rat plasma and its application to comparative pharmacokinetic study[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2016, 1026:105-113.
    [15] Chen J, Chen Z, Ma L, et al. Development of determination of four analytes of Zhi-Shao-San decoction using LC-MS/MS and its application to comparative pharmacokinetics in normal and irritable bowel syndrome rat plasma[J]. Biomed Chromatogr:BMC, 2014, 28(10):1384-1392.
    [16] Zhao M, Qian D, Shang E X, et al. Comparative pharmacokinetics of the main compounds of Shanzhuyu extract after oral administration in normal and chronic kidney disease rats[J]. J Ethnopharmacol, 2015, 173:280-286.
    [17] Zhao M, Qian D, Liu P, et al. Comparative pharmacokinetics of catalpol and acteoside in normal and chronic kidney disease rats after oral administration of Rehmannia glutinosa extract[J]. Biomed Chromatogr:BMC, 2015, 29(12):1842-1848.
    [18] He W, Liu G, Cai H, et al. Integrated pharmacokinetics of five protoberberine-type alkaloids in normal and insomnic rats after single and multiple oral administration of Jiao-Tai-Wan[J]. J Ethnopharmacol, 2014, 154(3):635-644.
    [19] Zhao X, Ma T, Zhang C, et al. Simultaneous determination of senkyunolide I and senkyunolide H in rat plasma by LC-MS:application to a comparative pharmacokinetic study in normal and migrainous rats after oral administration of Chuanxiong Rhizoma extract[J]. Biomed Chromatogr:BMC, 2015, 29(9):1297-1303.
    [20] Wang YH, Hong YL, Feng Y, et al. Comparative pharmacokinetics of senkyunolide I in a rat model of migraine versus normal controls[J]. Eur J Drug Metab Pharmacokinet, 2012, 37(2):91-97.
    [21] 朱黎霞,张英丰. 基于微透析技术结合液质联用的丹酚酸B正常和高脂血症大鼠药动学比较研究[J]. 中草药, 2015, 46(1):90-96.
    [22] 冯彬彬,张建海,牛小花,等. 川芎嗪、阿魏酸和延胡索乙素在模型与正常大鼠体内药动学比较研究[J]. 中草药, 2015, 46(10):1493-1497.
    [23] Wu Y, Ai Y, Wang F, et al. Simultaneous determination of four secoiridoid and iridoid glycosides in rat plasma by ultra performance liquid chromatography-tandem mass spectrometry and its application to a comparative pharmacokinetic study[J]. Biomed chromatogr:BMC, 2015, 30(2):97-104.
    [24] Wu Y, Wang F, Ai Y, et al. Simultaneous determination of seven coumarins by UPLC-MS/MS:Application to a comparative pharmacokinetic study in normal and arthritic rats after oral administration of Huo Luo Xiao Ling Dan or single-herb extract[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2015, 991:108-117.
    [25] 姜丽,高萌,屈飞,等. 基于HPLC-MS/MS研究麻杏石甘汤在正常及RSV肺炎感染模型大鼠体内的药动学[J]. 中国中药杂志, 2015, 40(13):2649-2655.
    [26] Gong XH, Li Y, Zhang RQ, et al. The synergism mechanism of Rhubarb Anthraquinones on constipation elucidated by comparative pharmacokinetics of Rhubarb extract between normal and diseased rats[J]. Eur J DrugMetab Pharmacokinet, 2015, 40(4):379-388.
    [27] 孟祥乐,李红伟,韩永龙,等. 栀子-连翘药对大鼠体内药动学变化特征研究[J]. 中国新药杂志, 2015, 24(17):2003-2009,2024.
    [28] Zeng XY, Dong S, He NN, et al. Comparative pharmacokinetics of arctigenin in normal and type 2 diabetic rats after oral and intravenous administration[J]. Fitoterapia, 2015, 105:119-126.
  • [1] 张艺昕, 关欣怡, 王博宁, 闻俊, 洪战英.  二氢吡啶类钙离子拮抗药物手性分析及其立体选择性药动学研究进展 . 药学实践与服务, 2024, 42(8): 319-324. doi: 10.12206/j.issn.2097-2024.202308062
    [2] 崔亚玲, 吴琼, 马良煜, 胡北, 姚东, 许子华.  肝素钠肌醇烟酸酯乳膏中肌醇烟酸酯皮肤药动学研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202404006
    [3] 夏哲炜, 曾垣烨, 朱海菲, 李育, 陈啸飞.  核磁共振磷谱法测定磷酸氢钙咀嚼片中药物含量 . 药学实践与服务, 2024, 42(9): 399-401, 406. doi: 10.12206/j.issn.2097-2024.202404063
    [4] 邹思, 吴岩斌, 吴锦忠, 吴建国, 黄家兴.  虎奶菇菌核多糖功能化纳米硒抗疲劳功效研究 . 药学实践与服务, 2024, 42(10): 426-432. doi: 10.12206/j.issn.2097-2024.202206072
    [5] 王鹏, 陈顺, 赵逸, 高守红, 王志鹏.  卡培他滨致小鼠手足综合征模型的建立及评价 . 药学实践与服务, 2024, 42(9): 385-388, 398. doi: 10.12206/j.issn.2097-2024.202308045
    [6] 王雪莲, 郑斯莉, 李志勇, 罗亨宇, 缪朝玉.  全身过表达人METRNL基因小鼠模型的构建与验证 . 药学实践与服务, 2024, 42(5): 198-202, 222. doi: 10.12206/j.issn.2097-2024.202311014
    [7] 赖立勇, 夏天爽, 徐圣焱, 蒋益萍, 岳小强, 辛海量.  中药青蒿抗氧化活性的谱效关系研究 . 药学实践与服务, 2024, 42(5): 203-210, 216. doi: 10.12206/j.issn.2097-2024.202211012
    [8] 费永和, 崔俐俊, 陈静.  应急状态下药品专利强制许可的几点思考 . 药学实践与服务, 2024, 42(7): 310-314. doi: 10.12206/j.issn.2097-2024.202309047
    [9] 杨嘉宁, 赵一颖, 肖伟.  七味脂肝方对非酒精性脂肪性肝炎动物模型的药效学评价 . 药学实践与服务, 2024, 42(9): 389-398. doi: 10.12206/j.issn.2097-2024.202404096
    [10] 陈炳辰, 佟达丰, 万苗, 闫飞虎, 姚建忠.  UPLC-MS/MS法测定小鼠血浆中紫杉醇脂肪酸酯前药及其药代动力学研究 . 药学实践与服务, 2024, 42(8): 341-345. doi: 10.12206/j.issn.2097-2024.202404082
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  3303
  • HTML全文浏览量:  359
  • PDF下载量:  409
  • 被引次数: 0
出版历程
  • 收稿日期:  2016-12-05
  • 修回日期:  2016-12-27

基于疾病动物模型的中药药动学研究进展

doi: 10.3969/j.issn.1006-0111.2017.02.003
  • 第二军医大学药学院药物分析学教研室, 上海 200433
    • 基金项目:  国家自然科学基金资助项目（81273472， 81573396）
  • 收稿日期: 2016-12-05
  • 修回日期: 2016-12-27

摘要: 中药药动学是中药现代化研究必不可少的环节，是中医药与世界接轨的重要手段。药物在作用部位只有达到足够浓度，才能在体内发挥药效，而药物浓度不仅与给药剂量有关，亦受到药物体内过程的影响。传统中药药动学研究多基于健康实验动物展开，忽视了疾病状态下生理和病理变化可能引起相关药动学参数显著改变。本文系统综述了近年来基于常见疾病动物模型开展的中药药动学比较研究，并对不同动物模型药动学比较的研究发展趋势进行讨论和展望。

English Abstract

王韵, 柴逸峰, 朱臻宇. 基于疾病动物模型的中药药动学研究进展[J]. 药学实践与服务, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003
引用本文: 王韵, 柴逸峰, 朱臻宇. 基于疾病动物模型的中药药动学研究进展[J]. 药学实践与服务, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003
shu
WANG Yun, CHAI Yifeng, ZHU Zhenyu. Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003
Citation: WANG Yun, CHAI Yifeng, ZHU Zhenyu. Advances on pharmacokinetics of traditional Chinese medicine based on animal model under diseased states[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(2): 108-111,140. doi: 10.3969/j.issn.1006-0111.2017.02.003
shu

    全文HTML

参考文献 (28)

目录

    /

    返回文章
    返回

    版权所有：《药学实践与服务》编辑委员会

    主管、主办: 中国人民解放军海军军医大学地址: 上海市杨浦区国和路325号邮政编码: 200433

    电话: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计