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线粒体靶向抗氧化剂研究进展

樊鹏程 葛越 蒋炜 景临林 马慧萍 贾正平

樊鹏程, 葛越, 蒋炜, 景临林, 马慧萍, 贾正平. 线粒体靶向抗氧化剂研究进展[J]. 药学实践与服务, 2015, 33(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2015.01.001
引用本文: 樊鹏程, 葛越, 蒋炜, 景临林, 马慧萍, 贾正平. 线粒体靶向抗氧化剂研究进展[J]. 药学实践与服务, 2015, 33(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2015.01.001
FAN Pengcheng, GE Yue, Jiang Wei, JING Linlin, MA Huiping, JIA Zhengping. Research progress in mitochondria-targeted antioxidants[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2015.01.001
Citation: FAN Pengcheng, GE Yue, Jiang Wei, JING Linlin, MA Huiping, JIA Zhengping. Research progress in mitochondria-targeted antioxidants[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2015.01.001

线粒体靶向抗氧化剂研究进展

doi: 10.3969/j.issn.1006-0111.2015.01.001
基金项目: 国家自然科学基金资助项目(81202458);全军医药卫生科研项目(CLZ12JB06)

Research progress in mitochondria-targeted antioxidants

  • 摘要: 线粒体是细胞呼吸的主要场所,在细胞的生命周期中扮演重要角色,三羧酸循环和氧化磷酸化都是在线粒体中进行。线粒体功能障碍可导致一系列疾病,如缺血-再灌注损伤、败血症和糖尿病等。线粒体是神经退行性病变的治疗靶点,也是药物转运策略研究的引人注目的靶位。虽然线粒体所介导的疾病进程的分子机制尚未完全阐明,但氧化应激是关键的环节。开发线粒体靶向的抗氧化应激保护药物具有诱人的前景。线粒体靶向抗氧化剂是指以线粒体为作用靶位的具有抗氧化作用的药物。该文介绍了现有的线粒体靶向抗氧化剂的概念、分类及其疾病治疗研究进展。
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线粒体靶向抗氧化剂研究进展

doi: 10.3969/j.issn.1006-0111.2015.01.001
    基金项目:  国家自然科学基金资助项目(81202458);全军医药卫生科研项目(CLZ12JB06)

摘要: 线粒体是细胞呼吸的主要场所,在细胞的生命周期中扮演重要角色,三羧酸循环和氧化磷酸化都是在线粒体中进行。线粒体功能障碍可导致一系列疾病,如缺血-再灌注损伤、败血症和糖尿病等。线粒体是神经退行性病变的治疗靶点,也是药物转运策略研究的引人注目的靶位。虽然线粒体所介导的疾病进程的分子机制尚未完全阐明,但氧化应激是关键的环节。开发线粒体靶向的抗氧化应激保护药物具有诱人的前景。线粒体靶向抗氧化剂是指以线粒体为作用靶位的具有抗氧化作用的药物。该文介绍了现有的线粒体靶向抗氧化剂的概念、分类及其疾病治疗研究进展。

English Abstract

樊鹏程, 葛越, 蒋炜, 景临林, 马慧萍, 贾正平. 线粒体靶向抗氧化剂研究进展[J]. 药学实践与服务, 2015, 33(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2015.01.001
引用本文: 樊鹏程, 葛越, 蒋炜, 景临林, 马慧萍, 贾正平. 线粒体靶向抗氧化剂研究进展[J]. 药学实践与服务, 2015, 33(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2015.01.001
FAN Pengcheng, GE Yue, Jiang Wei, JING Linlin, MA Huiping, JIA Zhengping. Research progress in mitochondria-targeted antioxidants[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2015.01.001
Citation: FAN Pengcheng, GE Yue, Jiang Wei, JING Linlin, MA Huiping, JIA Zhengping. Research progress in mitochondria-targeted antioxidants[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 1-4,8. doi: 10.3969/j.issn.1006-0111.2015.01.001
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