Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 28 Issue 1
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(1): 23-24,72

SUN Ting, ZOU Ying-xin, ZHENG Jie-min, HUANG Mao, ZHANG Xiao-dong. Effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 23-24,72.
Citation: SUN Ting, ZOU Ying-xin, ZHENG Jie-min, HUANG Mao, ZHANG Xiao-dong. Effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 23-24,72.
shu

Effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice

  • 1.

    Department of Pharmacy,Navy General Hospital,Beijing 100048,China

  • 2.

    Center of New Drug Evaluation,Second Military Medical University,Shanghai 200433,China

  • Received Date: 2009-06-25
  • Rev Recd Date: 2009-10-26
  • Objective To observe the effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice. Methods Male mice were used as subjects.Total range of motion after treated with morphine and haloperidol were evaluated by locomotion activity video analysis system.Total range of motion,average velocity and number of shuttle were also evaluated after the psychical dependence established. Results Distance travelled was significantly increased after administration of morphine.Distance travelled was significantly decreased in haloperidol group.Haloperidol could intercept hyperlocomotion induced by morphine.After treated with morphine,time to the morphine side significantly increased.Distance travelled,average velocity and number of shuttle also decreased significantly. Conclusion Haloperidol could suppress behavioral sensitization induced by morphine.The dopamine system functions may be inhibited after conditioned place preference established.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2252) PDF downloads(482) Cited by()

Related
Proportional views

Effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice

  • 1. Department of Pharmacy,Navy General Hospital,Beijing 100048,China
  • 2. Center of New Drug Evaluation,Second Military Medical University,Shanghai 200433,China
  • Received Date: 2009-06-25
  • Rev Recd Date: 2009-10-26

Abstract: Objective To observe the effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice. Methods Male mice were used as subjects.Total range of motion after treated with morphine and haloperidol were evaluated by locomotion activity video analysis system.Total range of motion,average velocity and number of shuttle were also evaluated after the psychical dependence established. Results Distance travelled was significantly increased after administration of morphine.Distance travelled was significantly decreased in haloperidol group.Haloperidol could intercept hyperlocomotion induced by morphine.After treated with morphine,time to the morphine side significantly increased.Distance travelled,average velocity and number of shuttle also decreased significantly. Conclusion Haloperidol could suppress behavioral sensitization induced by morphine.The dopamine system functions may be inhibited after conditioned place preference established.

SUN Ting, ZOU Ying-xin, ZHENG Jie-min, HUANG Mao, ZHANG Xiao-dong. Effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 23-24,72.
Citation: SUN Ting, ZOU Ying-xin, ZHENG Jie-min, HUANG Mao, ZHANG Xiao-dong. Effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 23-24,72.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return