Research progress in sinomenine structural modification

LI Xiuzheng; ZHAO Qingjie; DONG Jiaxiao; JIANG Yunyun; YE Guangming

doi:10.3969/j.issn.1006-0111.2018.03.003

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Sinomenine is an alkaloid found in the climbing plant Sinomenium acutum.Structurally, it belongs to the isoquinoline derivatives, which have various bioactivities.Clinically, it is used in the treatment for rheumatism, rheumatoid arthritis and arrhythmia, etc.Nevertheless, due to the need of large dose, photo and thermal instability, quick metabolism in vivo and highly allergic for some patients, scientists have committed to modify its structure to develop the highly effective and low toxic derivatives.In this paper, the recent advances in structural modification of sinomenine are reviewed.

Research progress in sinomenine structural modification

1. PLA 98 th Clinical College of Anhui Medical University, Huzhou 230032, China

2. Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

3. No. 101 Hospital of PLA, Wuxi 214044, China

Received Date: 2017-10-09

Rev Recd Date: 2017-12-29

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Abstract: Sinomenine is an alkaloid found in the climbing plant Sinomenium acutum.Structurally, it belongs to the isoquinoline derivatives, which have various bioactivities.Clinically, it is used in the treatment for rheumatism, rheumatoid arthritis and arrhythmia, etc.Nevertheless, due to the need of large dose, photo and thermal instability, quick metabolism in vivo and highly allergic for some patients, scientists have committed to modify its structure to develop the highly effective and low toxic derivatives.In this paper, the recent advances in structural modification of sinomenine are reviewed.

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Research progress in sinomenine structural modification

doi: 10.3969/j.issn.1006-0111.2018.03.003

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