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LIU Hong-yue, JIANG Jian, MA Lin, LIANG Yuan-yuan, DONG Fa-jie, CUI Li-li. Penetration enhancement of electret and united Azone on cyclosporin A transdermal delivery in vitro[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 440-442,466. doi: 10.3969/j.issn.1006-0111.2012.06.012
Citation: LIU Hong-yue, JIANG Jian, MA Lin, LIANG Yuan-yuan, DONG Fa-jie, CUI Li-li. Penetration enhancement of electret and united Azone on cyclosporin A transdermal delivery in vitro[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 440-442,466. doi: 10.3969/j.issn.1006-0111.2012.06.012

Penetration enhancement of electret and united Azone on cyclosporin A transdermal delivery in vitro

doi: 10.3969/j.issn.1006-0111.2012.06.012
  • Received Date: 2012-04-24
  • Rev Recd Date: 2012-09-10
  • Objective To study the penetration enhancement of electret and united Azone on cyclosporin A transdermalde livery in vitro. Methods Using corona charged -500 V, -1 000 V and -2 000 V polypropylene (PP) as electrets, 1%, 3% and 5% Azone as chemical enhancers, the transdermal behaviours of the cyclosporine A in solution were evaluated by modified Franze diffusion cell method. The concentration of cyclosporine A was measured by HPLC. Results All the electrets and chemical enhancers used in this study enhanced the cumulative penetration amount of the drug. The combination of -1 000 V and 1% Azone showed a slight increase in cumulative penetration amount of the drug compared with that of the 1% Azone used alone. Conclusion Both the negative electret and Azone could enhance the transdermal delivery of cyclosporin A individually. But negative electret and Azone had no synergistic enhancing effect on cyclosporin A transdermal delivery.
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    [2] 夏钟福. 驻极体[M]. 北京:科学出版社, 2001:2.
    [3] Cui LL, Hou XM, Jiang J, et al. Comparative enhancing effects of electret with chemical enhancers on trnasdermal delivery of meloxicam in vitro[J]. J Phys:Conf Ser, 2008, 142:012015.
    [4] 孔玉秀,程亮,肖永恒,等. 驻极体利多卡因贴剂的促渗作用[J].第二军医大学学报,2009,30(5):469.
    [5] Jiang J, Liang YY, Dong FJ, et al. Study of electret effect of rat skin by thermally stimulated discharge analysis[J]. J Electrostat,2012, 70:258.
    [6] 梁媛媛,董法杰,马琳,等. 驻极体对大鼠皮肤显微结构影响的时间效应研究[J]. 广东工业大学学报,2011,28(2):88.
    [7] Cui LL, Liang YY, Dong FJ, et al. Structure of rat skin after application of electret characterized by DSC[J]. J Phys:Conf Ser,2011, 301:012027.
    [8] Harrison JE, Watkinson AC, Green DM, et al. The relative effect of Azone and Transcutol on permeant diffusivity and solubility in human stratum corneum[J]. Pharm Res,1996, 13:542.
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Penetration enhancement of electret and united Azone on cyclosporin A transdermal delivery in vitro

doi: 10.3969/j.issn.1006-0111.2012.06.012

Abstract: Objective To study the penetration enhancement of electret and united Azone on cyclosporin A transdermalde livery in vitro. Methods Using corona charged -500 V, -1 000 V and -2 000 V polypropylene (PP) as electrets, 1%, 3% and 5% Azone as chemical enhancers, the transdermal behaviours of the cyclosporine A in solution were evaluated by modified Franze diffusion cell method. The concentration of cyclosporine A was measured by HPLC. Results All the electrets and chemical enhancers used in this study enhanced the cumulative penetration amount of the drug. The combination of -1 000 V and 1% Azone showed a slight increase in cumulative penetration amount of the drug compared with that of the 1% Azone used alone. Conclusion Both the negative electret and Azone could enhance the transdermal delivery of cyclosporin A individually. But negative electret and Azone had no synergistic enhancing effect on cyclosporin A transdermal delivery.

LIU Hong-yue, JIANG Jian, MA Lin, LIANG Yuan-yuan, DONG Fa-jie, CUI Li-li. Penetration enhancement of electret and united Azone on cyclosporin A transdermal delivery in vitro[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 440-442,466. doi: 10.3969/j.issn.1006-0111.2012.06.012
Citation: LIU Hong-yue, JIANG Jian, MA Lin, LIANG Yuan-yuan, DONG Fa-jie, CUI Li-li. Penetration enhancement of electret and united Azone on cyclosporin A transdermal delivery in vitro[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 440-442,466. doi: 10.3969/j.issn.1006-0111.2012.06.012
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