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WANG Yun, CAO Yong-bing, JIANG Yuan-ying, YAN Tian-hua. Clinical application of Sugammadex[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 405-407,453. doi: 10.3969/j.issn.1006-0111.2012.06.002
Citation: WANG Yun, CAO Yong-bing, JIANG Yuan-ying, YAN Tian-hua. Clinical application of Sugammadex[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 405-407,453. doi: 10.3969/j.issn.1006-0111.2012.06.002

Clinical application of Sugammadex

doi: 10.3969/j.issn.1006-0111.2012.06.002
  • Received Date: 2012-03-14
  • Rev Recd Date: 2012-05-02
  • Sugammadex had been licensed for reversal of rocuronium and vecuronium induced neuromuscular blockade in Europe since 2008, which had shown to be efficacious and had a good safety profile so far. The potential for Sugammadex to change the management of NMB, in routine clinical practice, in emergency situations and in special populations were reviewed in this paper.
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    [6] McTernan CN, Rapeport DA, Ledowski T. Successful use of rocuronium and sugammadex in an anticipated difficult airway scenario[J]. Anaesth Intensive Care,2010,38(2):390.
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    [8] Jones RK, Caldwell JE, Brull SJ, et al. Reversal of profound rocuronium induced blockade with sugammadex:a randomized comparison with neostigmine[J].Anesthesiology,2008, 109(5):816.
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    [11] Plaud B, Meretoja O, Hofmockel R, et al. Reversal of rocuronium-induced neuromuscular blockade with sugammadex in pediatric and adult surgical patients[J]. Anesthesiology, 2009, 110(2):284.
    [12] Suzuki T, Kitajima O, Ueda K, et al. Reversibility of rocuronium-induced profound neuromuscular block with sugammadex in younger and older patients[J]. Br J Anaesth, 2011,106(6):823.
    [13] Monk T. Obesity has no clinically relevant impact upon recovery time following administration of sugammadex[C]. Presented at Annual Meeting of American Society of Anesthesiologists. Orlando:2008. Abstract A682.
    [14] Desforges JC, McDonnell NJ. Sugammadex in the management of a failed intubation in a morbidly obese patient[J]. Anaesth Intensive Care, 2011,39(4):763.
    [15] Van Lancker P, Dillemans B, Bogaert T, et al. Ideal versus corrected body weight for dosage of sugammadex in morbidly obese patients[J]. Anaesthesia, 2011,66(8):721.
    [16] Sharp LM, Levy DM. Rapid sequence induction in obstetrics revisited[J]. Curr Opin Anaesthesiol, 2009,22(3):357
    [17] Puhringer FK, Kristen P, Rex C. Sugammadex reversal of rocuronium-induced neuromuscular block in Caesarean section patients:a series of seven cases[J]. Br J Anaesth, 2010, 105(5):657.
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    [22] Porter MV, Paleologos MS. The use of rocuronium in a patient with cystic fibrosis and end-stage lung disease made safe by sugammadex reversal[J]. Anaesth Intensive Care, 2011, 39(2):299.
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    [24] Matsuki Y, Hirose M, Tabata M, et al. The use of sugammadex in a patient with myotonic dystrophy[J].Eur J Anaesthesiol,2010,28(2):145.
    [25] de Boer HD, van Esmond J, Booij LH, et al. Reversal of rocuronium induced profound neuromuscular block by sugammadex in Duchenne muscular dystrophy[J]. Paediatr Anaesth, 2009, 19(12):1226
    [26] Cammu G, De Kam PJ, Demeyer I, et al. Safety and tolerability of single intravenous doses of sugammadex administered simultaneously with rocuronium or vecuronium in healthy volunteers[J]. Br J Anaesth, 2008, 100(3):373
    [27] de Kam PJ, van Kuijk J, Prohn M, et al. Effects of sugammadex doses up to 32 mg/kg alone or in combination with rocuroniumor vecuroniumon QTc prolongation:a thorough QTc study[J]. Clin Drug Investig, 2010, 30(9):599.
    [28] Peeters PA, Michiel W,Heuvel VD, et al. Safety, tolerability and pharmacokinetics of sugammadex using single high doses (up to 96 mg/kg) in healthy adult subjects:a randomized,double-blind, crossover, placebo-controlled, single-centre study[J]. Clin Drug Investig, 2010, 30(12):867.
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    [30] Paton F, Paulden M, Chambers D, et al. Sugammadex compared with neostigmine/glycopyrrolate for routine reversal of neuromuscular block:a systematic review and economic evaluation[J]. Br J Anaesth, 2010, 105(5):558.
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Clinical application of Sugammadex

doi: 10.3969/j.issn.1006-0111.2012.06.002

Abstract: Sugammadex had been licensed for reversal of rocuronium and vecuronium induced neuromuscular blockade in Europe since 2008, which had shown to be efficacious and had a good safety profile so far. The potential for Sugammadex to change the management of NMB, in routine clinical practice, in emergency situations and in special populations were reviewed in this paper.

WANG Yun, CAO Yong-bing, JIANG Yuan-ying, YAN Tian-hua. Clinical application of Sugammadex[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 405-407,453. doi: 10.3969/j.issn.1006-0111.2012.06.002
Citation: WANG Yun, CAO Yong-bing, JIANG Yuan-ying, YAN Tian-hua. Clinical application of Sugammadex[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 405-407,453. doi: 10.3969/j.issn.1006-0111.2012.06.002
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