Progress of Raman spectroscopy in fast detection of counterfeit drugs

LIU Yan; YIN Li-hui; LU Feng

doi:10.3969/j.issn.1006-0111.2012.06.001

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2012 > 30(6): 401-404,446

LIU Yan, YIN Li-hui, LU Feng. Progress of Raman spectroscopy in fast detection of counterfeit drugs[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 401-404,446. doi: 10.3969/j.issn.1006-0111.2012.06.001

Citation:

LIU Yan, YIN Li-hui, LU Feng. Progress of Raman spectroscopy in fast detection of counterfeit drugs[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 401-404,446. doi: 10.3969/j.issn.1006-0111.2012.06.001

Progress of Raman spectroscopy in fast detection of counterfeit drugs

doi: 10.3969/j.issn.1006-0111.2012.06.001

1.
Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
2.
National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China

Received Date: 2012-04-02
Rev Recd Date: 2012-06-28

Abstract

Counterfeit drugs not only affected drug safe and function, but also disturbed the commerce and social order. It had become so urgently to combat counterfeit drugs. Recently, Raman spectroscopy had been a more and more popular technique in the fast detection of counterfeits. In this paper, the advantages of Raman spectroscopy in fast detection of counterfeit drugs were explained. Combined with the discussion of the methods of the spectral pretreatment and qualitative analysis, the application of Raman spectroscopy in fast detection of counterfeit drugs was reviewed. On the basis of the overview of the present progress of the Raman spectroscopy in fast detection, the future research direction and areas were forecasted.
- Raman spectroscopy,
- counterfeit drugs,
- fast detection,
- review

References

[1]	陆峰,乐健,陈桂良,等. 中药掺杂化学药物的分析及其对策[J]. 中国中药杂志,2007,32(1):6.
[2]	Ricci C,Nyadong L,Yang F,et al. Assessment of hand-held Raman instrumentation for in situ screening for potentially counterfeit artesunate antimalarial tablets by FT-Raman spectroscopy and direct ionization mass spectrometry[J]. Anal Chim Acta,2008,623(2):178.
[3]	Day JS,Edwards HG,Dobrowski SA,et al.The detection of drugs of abuse in fingerprints using Raman spectroscopy I:latent fingerprints[J]. Spectrochim Acta A Mol Biomol Spectrosc,2004,60(3):563.
[4]	Li P,Ren J,Duan C,et al.Effects of four components of Rhizoma Corydalis on anoxia and peroxidation injuries in neonatal cardiomyocytes[J]. Chin J Chin Materia Medica,2010, 35(1):84.
[5]	Liang XL,Liao ZG,Wang GF,et al.Influence of combination of extractum Angelicae Dahuricae Siccum and total alkaloids of Rhizoma Corydalis on pharmacokinetics of tetrahydropalmatine in rats[J]. Acta Pharm Sinica,2009,44(6):645.
[6]	Qiu YX,Zong M,Yao Y,et al.Genetic variation in wild and cultivated rhizoma corydalis revealed by ISSRs markers[J]. Planta Med,2009,75(1):94.
[7]	翁欣欣,张中湖,尹利辉,等. KPCA-聚类分析法和用便携式拉曼仪快速鉴别降糖药[J]. 光谱学与光谱分析,2010,30(4):984.
[8]	de Veij M,Deneckere A,Vandenabeele P,et al.Detection of counterfeit Viagra with Raman spectroscopy[J]. J Pharm Biomed Anal,2008,46(2):303.
[9]	冯昕鞋,朱仲良,沈梦洁,等.基于多项式拟合的拉曼光谱基线漂移校正方法[J]. 计算机与应用化学,2009,26(6):759.
[10]	Ricci C,Eliasson C,Macleod NA,et al.Characterization of genuine and fake artesunate anti-malarial tablets using Fourier transform infrared imaging and spatially offset Raman spectroscopy through blister packs[J]. Anal Bioanal Chem,2007,389(5):1525.
[11]	曹玲,石蓓佳,吴莉,等. 常用羧酸类及其衍生物药用辅料的拉曼光谱鉴别[J]. 药物分析杂志,2010(3):484.
[12]	刘畅,张中湖,柳艳,等.拉曼光谱-区段相似度法用于降糖类药物的快速检测[J]. 药学服务与研究,2011,11(3):196.
[13]	范贤松,张先芬,沈高山.便携式拉曼光谱仪快速鉴别多潘立酮片真伪的研究[J]. 安徽医药,2010,14(12):1501.
[14]	孙振球,徐勇勇. 医学统计学[M]. 第2版. 北京:人民卫生出版社,2008:384~396.
[15]	柳艳,张中湖,陆峰.降糖类药物的拉曼光谱-小模型判别方法研究[J]. 计算机与应用化学,2012,28(11):1433.
[16]	Been F,Roggo Y,Degardin K,et al.Profiling of counterfeit medicines by vibrational spectroscopy[J]. Forensic Sci Int,2011,211(1-3):83.
[17]	Sacre PY,Deconinck E,Saerens L,et al.Detection of counterfeit Viagra by Raman microspectroscopy imaging and multivariate analysis[J]. J Pharm Biomed Anal,2011,56(2):454.
[18]	陆峰,吴玉田. 无模型光谱分析策略[J]. 光谱仪器与分析,2009,(1-3):40.
[19]	Lu F,Li S,Le J,et al.A new method for testing synthetic drugs adulterated in herbal medicines based on infrared spectroscopy[J]. Anal Chim Acta,2007,589(2):200.
[20]	Xueyi Z,Zhonghu Z,Feng L,et al.Modified local straight-line screening to detect synthetic drugs in adulterated herbal medicines[J]. Appl Spectrosc,2009,63(4):471.
[21]	罗娅,柳艳,胡茜茜,等. 便携式拉曼光谱仪用于降糖药品快速检测的研究[J]. 药学实践杂志,2011,29(1):35.
[22]	宋清,翁欣欣,陆峰.用于降糖类药物真伪快速检测的3种拉曼光谱处理方法的比较[J]. 第二军医大学学报,2010,31(9):993.
[23]	曹玲,王玉,罗疆南. 显微共聚焦拉曼检测中药中非法添加的化学降糖药[J]. 药物分析杂志,2011,31(3):539.
[24]	Ricci C,Nyadong L,Yang F,et al.Assessment of hand-held Raman instrumentation for in situ screening for potentially counterfeit artesunate antimalarial tablets by FT-Raman spectroscopy and direct ionization mass spectrometry[J]. Anal Chim Acta,2008,623(2):178.
[25]	De Veij M,Vandenabeele P,Hall KA,et al.Fast detection and identification of counterfeit antimalarial tablets by Raman spectroscopy[J]. J Raman Spectrosc,2007,38(2):181.
[26]	De Peinder P,Vredenbregt MJ,Visser T,et al.Detection of Lipitor counterfeits:a comparison of NIR and Raman spectroscopy in combination with chemometrics[J]. J Pharm Biomed Anal,2008,47(4-5):688.
[27]	王玉,曹玲,罗疆南.显微共聚焦拉曼光谱法检测非法添加的化学壮阳药[J]. 中国药学杂志,2011,46(10):789.
[28]	Trefi S,Routaboul C,Hamieh S,et al.Analysis of illegally manufactured formulations of tadalafil (Cialis) by ¹H NMR,2D-DOSY ¹H NMR and Raman spectroscopy[J]. J Pharm Biomed Anal,2008,47(1):103.
[29]	Sacre PY,Deconinck E,De Beer T,et al.Comparison and combination of spectroscopic techniques for the detection of counterfeit medicines[J]. J Pharm Biomed Anal,2010,53(3):445.
[30]	Degardin K,Roggo Y,Been F,et al.Detection and chemical profiling of medicine counterfeits by Raman spectroscopy and chemometrics[J]. Anal Chim Acta,2011,705(1-2):334.
[31]	Roggo Y,Degardin K,Margot P.Identification of pharmaceutical tablets by Raman spectroscopy and chemometrics[J]. Talanta,2010,81(3):988.

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Progress of Raman spectroscopy in fast detection of counterfeit drugs

1. Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

2. National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China

Received Date: 2012-04-02

Rev Recd Date: 2012-06-28

Key words:

Abstract: Counterfeit drugs not only affected drug safe and function, but also disturbed the commerce and social order. It had become so urgently to combat counterfeit drugs. Recently, Raman spectroscopy had been a more and more popular technique in the fast detection of counterfeits. In this paper, the advantages of Raman spectroscopy in fast detection of counterfeit drugs were explained. Combined with the discussion of the methods of the spectral pretreatment and qualitative analysis, the application of Raman spectroscopy in fast detection of counterfeit drugs was reviewed. On the basis of the overview of the present progress of the Raman spectroscopy in fast detection, the future research direction and areas were forecasted.

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Reference (31)

[1]	陆峰,乐健,陈桂良,等. 中药掺杂化学药物的分析及其对策[J]. 中国中药杂志,2007,32(1):6.
[2]	Ricci C,Nyadong L,Yang F,et al. Assessment of hand-held Raman instrumentation for in situ screening for potentially counterfeit artesunate antimalarial tablets by FT-Raman spectroscopy and direct ionization mass spectrometry[J]. Anal Chim Acta,2008,623(2):178.
[3]	Day JS,Edwards HG,Dobrowski SA,et al.The detection of drugs of abuse in fingerprints using Raman spectroscopy I:latent fingerprints[J]. Spectrochim Acta A Mol Biomol Spectrosc,2004,60(3):563.
[4]	Li P,Ren J,Duan C,et al.Effects of four components of Rhizoma Corydalis on anoxia and peroxidation injuries in neonatal cardiomyocytes[J]. Chin J Chin Materia Medica,2010, 35(1):84.
[5]	Liang XL,Liao ZG,Wang GF,et al.Influence of combination of extractum Angelicae Dahuricae Siccum and total alkaloids of Rhizoma Corydalis on pharmacokinetics of tetrahydropalmatine in rats[J]. Acta Pharm Sinica,2009,44(6):645.
[6]	Qiu YX,Zong M,Yao Y,et al.Genetic variation in wild and cultivated rhizoma corydalis revealed by ISSRs markers[J]. Planta Med,2009,75(1):94.
[7]	翁欣欣,张中湖,尹利辉,等. KPCA-聚类分析法和用便携式拉曼仪快速鉴别降糖药[J]. 光谱学与光谱分析,2010,30(4):984.
[8]	de Veij M,Deneckere A,Vandenabeele P,et al.Detection of counterfeit Viagra with Raman spectroscopy[J]. J Pharm Biomed Anal,2008,46(2):303.
[9]	冯昕鞋,朱仲良,沈梦洁,等.基于多项式拟合的拉曼光谱基线漂移校正方法[J]. 计算机与应用化学,2009,26(6):759.
[10]	Ricci C,Eliasson C,Macleod NA,et al.Characterization of genuine and fake artesunate anti-malarial tablets using Fourier transform infrared imaging and spatially offset Raman spectroscopy through blister packs[J]. Anal Bioanal Chem,2007,389(5):1525.
[11]	曹玲,石蓓佳,吴莉,等. 常用羧酸类及其衍生物药用辅料的拉曼光谱鉴别[J]. 药物分析杂志,2010(3):484.
[12]	刘畅,张中湖,柳艳,等.拉曼光谱-区段相似度法用于降糖类药物的快速检测[J]. 药学服务与研究,2011,11(3):196.
[13]	范贤松,张先芬,沈高山.便携式拉曼光谱仪快速鉴别多潘立酮片真伪的研究[J]. 安徽医药,2010,14(12):1501.
[14]	孙振球,徐勇勇. 医学统计学[M]. 第2版. 北京:人民卫生出版社,2008:384~396.
[15]	柳艳,张中湖,陆峰.降糖类药物的拉曼光谱-小模型判别方法研究[J]. 计算机与应用化学,2012,28(11):1433.
[16]	Been F,Roggo Y,Degardin K,et al.Profiling of counterfeit medicines by vibrational spectroscopy[J]. Forensic Sci Int,2011,211(1-3):83.
[17]	Sacre PY,Deconinck E,Saerens L,et al.Detection of counterfeit Viagra by Raman microspectroscopy imaging and multivariate analysis[J]. J Pharm Biomed Anal,2011,56(2):454.
[18]	陆峰,吴玉田. 无模型光谱分析策略[J]. 光谱仪器与分析,2009,(1-3):40.
[19]	Lu F,Li S,Le J,et al.A new method for testing synthetic drugs adulterated in herbal medicines based on infrared spectroscopy[J]. Anal Chim Acta,2007,589(2):200.
[20]	Xueyi Z,Zhonghu Z,Feng L,et al.Modified local straight-line screening to detect synthetic drugs in adulterated herbal medicines[J]. Appl Spectrosc,2009,63(4):471.
[21]	罗娅,柳艳,胡茜茜,等. 便携式拉曼光谱仪用于降糖药品快速检测的研究[J]. 药学实践杂志,2011,29(1):35.
[22]	宋清,翁欣欣,陆峰.用于降糖类药物真伪快速检测的3种拉曼光谱处理方法的比较[J]. 第二军医大学学报,2010,31(9):993.
[23]	曹玲,王玉,罗疆南. 显微共聚焦拉曼检测中药中非法添加的化学降糖药[J]. 药物分析杂志,2011,31(3):539.
[24]	Ricci C,Nyadong L,Yang F,et al.Assessment of hand-held Raman instrumentation for in situ screening for potentially counterfeit artesunate antimalarial tablets by FT-Raman spectroscopy and direct ionization mass spectrometry[J]. Anal Chim Acta,2008,623(2):178.
[25]	De Veij M,Vandenabeele P,Hall KA,et al.Fast detection and identification of counterfeit antimalarial tablets by Raman spectroscopy[J]. J Raman Spectrosc,2007,38(2):181.
[26]	De Peinder P,Vredenbregt MJ,Visser T,et al.Detection of Lipitor counterfeits:a comparison of NIR and Raman spectroscopy in combination with chemometrics[J]. J Pharm Biomed Anal,2008,47(4-5):688.
[27]	王玉,曹玲,罗疆南.显微共聚焦拉曼光谱法检测非法添加的化学壮阳药[J]. 中国药学杂志,2011,46(10):789.
[28]	Trefi S,Routaboul C,Hamieh S,et al.Analysis of illegally manufactured formulations of tadalafil (Cialis) by ¹H NMR,2D-DOSY ¹H NMR and Raman spectroscopy[J]. J Pharm Biomed Anal,2008,47(1):103.
[29]	Sacre PY,Deconinck E,De Beer T,et al.Comparison and combination of spectroscopic techniques for the detection of counterfeit medicines[J]. J Pharm Biomed Anal,2010,53(3):445.
[30]	Degardin K,Roggo Y,Been F,et al.Detection and chemical profiling of medicine counterfeits by Raman spectroscopy and chemometrics[J]. Anal Chim Acta,2011,705(1-2):334.
[31]	Roggo Y,Degardin K,Margot P.Identification of pharmaceutical tablets by Raman spectroscopy and chemometrics[J]. Talanta,2010,81(3):988.

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Progress of Raman spectroscopy in fast detection of counterfeit drugs

doi: 10.3969/j.issn.1006-0111.2012.06.001

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References

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通讯作者: 陈斌, bchen63@163.com

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