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糠酸氟替卡松/维兰特罗复方剂治疗哮喘疗效与耐受性的Meta分析

林莉莉 姚囡囡 吴珏 刘志宏 宋洪涛

林莉莉, 姚囡囡, 吴珏, 刘志宏, 宋洪涛. 糠酸氟替卡松/维兰特罗复方剂治疗哮喘疗效与耐受性的Meta分析[J]. 药学实践与服务, 2019, 37(5): 473-480. doi: 10.3969/j.issn.1006-0111.2019.05.018
引用本文: 林莉莉, 姚囡囡, 吴珏, 刘志宏, 宋洪涛. 糠酸氟替卡松/维兰特罗复方剂治疗哮喘疗效与耐受性的Meta分析[J]. 药学实践与服务, 2019, 37(5): 473-480. doi: 10.3969/j.issn.1006-0111.2019.05.018
LIN Lili, YAO Nannan, WU Jue, LIU Zhihong, SONG Hongtao. Efficacy and safety of fluticasone furoate/vilanterol in patients with asthma: a systematic review by Meta-analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 473-480. doi: 10.3969/j.issn.1006-0111.2019.05.018
Citation: LIN Lili, YAO Nannan, WU Jue, LIU Zhihong, SONG Hongtao. Efficacy and safety of fluticasone furoate/vilanterol in patients with asthma: a systematic review by Meta-analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 473-480. doi: 10.3969/j.issn.1006-0111.2019.05.018

糠酸氟替卡松/维兰特罗复方剂治疗哮喘疗效与耐受性的Meta分析

doi: 10.3969/j.issn.1006-0111.2019.05.018

Efficacy and safety of fluticasone furoate/vilanterol in patients with asthma: a systematic review by Meta-analysis

  • 摘要: 目的 比较糠酸氟替卡松/维兰特罗复方剂(FF/VI)与吸入型糖皮质激素单药或联合长效β2受体激动剂治疗哮喘患者的疗效与耐受性差异。 方法 计算机检索CNKI、PubMed、Embase、Cochrane Library等数据库,纳入随机对照试验,采用Cochrane系统评价方法进行评价。 结果 共纳入10个研究,共9 811例患者。在疗效上,FF/VI组与对照组相比,提高患者的1秒用力呼气量谷值[WMD=0.09,95% CI(0.05,0.13),P=0.000]和哮喘控制测试评分[WMD=0.63,95% CI(0.24,1.03),P=0.002]。在耐受性方面,FF/VI组与对照组相比不增加患者发生与治疗相关不良反应事件风险[RR=1.15,95% CI(0.98,1.36),P=0.000]。 结论 用FF/VI治疗哮喘在疗效方面具有优势,且具有良好的耐受性。其每日1次的用药频次可提高患者依从性,值得推荐使用。
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糠酸氟替卡松/维兰特罗复方剂治疗哮喘疗效与耐受性的Meta分析

doi: 10.3969/j.issn.1006-0111.2019.05.018

摘要: 目的 比较糠酸氟替卡松/维兰特罗复方剂(FF/VI)与吸入型糖皮质激素单药或联合长效β2受体激动剂治疗哮喘患者的疗效与耐受性差异。 方法 计算机检索CNKI、PubMed、Embase、Cochrane Library等数据库,纳入随机对照试验,采用Cochrane系统评价方法进行评价。 结果 共纳入10个研究,共9 811例患者。在疗效上,FF/VI组与对照组相比,提高患者的1秒用力呼气量谷值[WMD=0.09,95% CI(0.05,0.13),P=0.000]和哮喘控制测试评分[WMD=0.63,95% CI(0.24,1.03),P=0.002]。在耐受性方面,FF/VI组与对照组相比不增加患者发生与治疗相关不良反应事件风险[RR=1.15,95% CI(0.98,1.36),P=0.000]。 结论 用FF/VI治疗哮喘在疗效方面具有优势,且具有良好的耐受性。其每日1次的用药频次可提高患者依从性,值得推荐使用。

English Abstract

林莉莉, 姚囡囡, 吴珏, 刘志宏, 宋洪涛. 糠酸氟替卡松/维兰特罗复方剂治疗哮喘疗效与耐受性的Meta分析[J]. 药学实践与服务, 2019, 37(5): 473-480. doi: 10.3969/j.issn.1006-0111.2019.05.018
引用本文: 林莉莉, 姚囡囡, 吴珏, 刘志宏, 宋洪涛. 糠酸氟替卡松/维兰特罗复方剂治疗哮喘疗效与耐受性的Meta分析[J]. 药学实践与服务, 2019, 37(5): 473-480. doi: 10.3969/j.issn.1006-0111.2019.05.018
LIN Lili, YAO Nannan, WU Jue, LIU Zhihong, SONG Hongtao. Efficacy and safety of fluticasone furoate/vilanterol in patients with asthma: a systematic review by Meta-analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 473-480. doi: 10.3969/j.issn.1006-0111.2019.05.018
Citation: LIN Lili, YAO Nannan, WU Jue, LIU Zhihong, SONG Hongtao. Efficacy and safety of fluticasone furoate/vilanterol in patients with asthma: a systematic review by Meta-analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 473-480. doi: 10.3969/j.issn.1006-0111.2019.05.018
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