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长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展

丁佳宁 马进原 朱全刚

丁佳宁, 马进原, 朱全刚. 长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展[J]. 药学实践与服务, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
引用本文: 丁佳宁, 马进原, 朱全刚. 长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展[J]. 药学实践与服务, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
DING Jianing, MA Jinyuan, ZHU Quangang. Research progress of lncRNA MEG3 in tumorigenesis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
Citation: DING Jianing, MA Jinyuan, ZHU Quangang. Research progress of lncRNA MEG3 in tumorigenesis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002

长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展

doi: 10.3969/j.issn.1006-0111.2019.05.002
基金项目: 国家自然科学基金(81472394);上海市皮肤病医院国家自然科学基金培育项目(17GZRPY11)

Research progress of lncRNA MEG3 in tumorigenesis

  • 摘要: 长链非编码RNA(long non-coding RNA,lncRNA)覆盖了人类DNA的大部分非编码信息,占整个基因组的90%以上,它们构成了一个广泛而复杂的分子群,在肿瘤的病理生理过程中以多种形式存在。2003年,lncRNA人母系表达基因(MEG)3被证明是垂体瘤的一个潜在的肿瘤抑制因子,之后研究者又在脑膜瘤、肝癌、肺癌、神经内分泌瘤,以及前列腺癌等其他肿瘤上对其在基因表达调控、印记、转录和翻译后的作用上进行了研究,发现MEG3在多种恶性肿瘤组织中低表达或表达缺失,而上调MEG3的表达与肿瘤生长抑制相关,其在肿瘤发生中的作用和机制得到了更好地阐明。总结MEG3的功能及在肿瘤发生中的研究进展。
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长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展

doi: 10.3969/j.issn.1006-0111.2019.05.002
    基金项目:  国家自然科学基金(81472394);上海市皮肤病医院国家自然科学基金培育项目(17GZRPY11)

摘要: 长链非编码RNA(long non-coding RNA,lncRNA)覆盖了人类DNA的大部分非编码信息,占整个基因组的90%以上,它们构成了一个广泛而复杂的分子群,在肿瘤的病理生理过程中以多种形式存在。2003年,lncRNA人母系表达基因(MEG)3被证明是垂体瘤的一个潜在的肿瘤抑制因子,之后研究者又在脑膜瘤、肝癌、肺癌、神经内分泌瘤,以及前列腺癌等其他肿瘤上对其在基因表达调控、印记、转录和翻译后的作用上进行了研究,发现MEG3在多种恶性肿瘤组织中低表达或表达缺失,而上调MEG3的表达与肿瘤生长抑制相关,其在肿瘤发生中的作用和机制得到了更好地阐明。总结MEG3的功能及在肿瘤发生中的研究进展。

English Abstract

丁佳宁, 马进原, 朱全刚. 长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展[J]. 药学实践与服务, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
引用本文: 丁佳宁, 马进原, 朱全刚. 长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展[J]. 药学实践与服务, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
DING Jianing, MA Jinyuan, ZHU Quangang. Research progress of lncRNA MEG3 in tumorigenesis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
Citation: DING Jianing, MA Jinyuan, ZHU Quangang. Research progress of lncRNA MEG3 in tumorigenesis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
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