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应中央军委要求,2022年9月起,《药学实践杂志》将更名为《药学实践与服务》,双月刊,正文96页;2023年1月起,拟出版月刊,正文64页,数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿!

肥胖2型糖尿病药物研究进展

张宇 王鹏源 刘霞

张宇, 王鹏源, 刘霞. 肥胖2型糖尿病药物研究进展[J]. 药学实践与服务, 2019, 37(2): 97-102. doi: 10.3969/j.issn.1006-0111.2019.02.001
引用本文: 张宇, 王鹏源, 刘霞. 肥胖2型糖尿病药物研究进展[J]. 药学实践与服务, 2019, 37(2): 97-102. doi: 10.3969/j.issn.1006-0111.2019.02.001
ZHANG Yu, WANG Pengyuan, LIU Xia. Research progress on obesity type 2 diabetes mellitus drug[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 97-102. doi: 10.3969/j.issn.1006-0111.2019.02.001
Citation: ZHANG Yu, WANG Pengyuan, LIU Xia. Research progress on obesity type 2 diabetes mellitus drug[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 97-102. doi: 10.3969/j.issn.1006-0111.2019.02.001

肥胖2型糖尿病药物研究进展

doi: 10.3969/j.issn.1006-0111.2019.02.001
基金项目: 重大新药创制科技重大专项(2018ZX09711002-003-015),上海市"科技创新行动计划"生物医药领域科技支撑项目(18431900800);国家自然科学基金(81473259,81773726)

Research progress on obesity type 2 diabetes mellitus drug

  • 摘要: 肥胖与糖尿病发病率密切相关,是糖尿病发病率上升的重要原因。如今上市的大部分降糖药物如胰岛素及其类似物、胰岛素促泌剂、胰岛素增敏剂等都会不同程度的增加患者体重,从而加重胰岛素抵抗,增加降糖药物剂量,形成恶性循环,降糖兼具减肥是当今糖尿病新药研发重要趋势。本文概述了肥胖2型糖尿病的流行病学以及目前上市的降糖药物对体重发展的影响,并重点概述了兼具减肥效应的降糖药物的最新靶点,为肥胖2型糖尿病患者的治疗提供潜在新方法。
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肥胖2型糖尿病药物研究进展

doi: 10.3969/j.issn.1006-0111.2019.02.001
    基金项目:  重大新药创制科技重大专项(2018ZX09711002-003-015),上海市"科技创新行动计划"生物医药领域科技支撑项目(18431900800);国家自然科学基金(81473259,81773726)

摘要: 肥胖与糖尿病发病率密切相关,是糖尿病发病率上升的重要原因。如今上市的大部分降糖药物如胰岛素及其类似物、胰岛素促泌剂、胰岛素增敏剂等都会不同程度的增加患者体重,从而加重胰岛素抵抗,增加降糖药物剂量,形成恶性循环,降糖兼具减肥是当今糖尿病新药研发重要趋势。本文概述了肥胖2型糖尿病的流行病学以及目前上市的降糖药物对体重发展的影响,并重点概述了兼具减肥效应的降糖药物的最新靶点,为肥胖2型糖尿病患者的治疗提供潜在新方法。

English Abstract

张宇, 王鹏源, 刘霞. 肥胖2型糖尿病药物研究进展[J]. 药学实践与服务, 2019, 37(2): 97-102. doi: 10.3969/j.issn.1006-0111.2019.02.001
引用本文: 张宇, 王鹏源, 刘霞. 肥胖2型糖尿病药物研究进展[J]. 药学实践与服务, 2019, 37(2): 97-102. doi: 10.3969/j.issn.1006-0111.2019.02.001
ZHANG Yu, WANG Pengyuan, LIU Xia. Research progress on obesity type 2 diabetes mellitus drug[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 97-102. doi: 10.3969/j.issn.1006-0111.2019.02.001
Citation: ZHANG Yu, WANG Pengyuan, LIU Xia. Research progress on obesity type 2 diabetes mellitus drug[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(2): 97-102. doi: 10.3969/j.issn.1006-0111.2019.02.001
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