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应中央军委要求,2022年9月起,《药学实践杂志》将更名为《药学实践与服务》,双月刊,正文96页;2023年1月起,拟出版月刊,正文64页,数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿!

胱氨酸结模体多肽的特征及其在药物设计和分子工程中的应用

邓宇晨 顾嘉伟 聂菲 肖良

邓宇晨, 顾嘉伟, 聂菲, 肖良. 胱氨酸结模体多肽的特征及其在药物设计和分子工程中的应用[J]. 药学实践与服务, 2016, 34(6): 481-484,496. doi: 10.3969/j.issn.1006-0111.2016.06.001
引用本文: 邓宇晨, 顾嘉伟, 聂菲, 肖良. 胱氨酸结模体多肽的特征及其在药物设计和分子工程中的应用[J]. 药学实践与服务, 2016, 34(6): 481-484,496. doi: 10.3969/j.issn.1006-0111.2016.06.001
DENG Yuchen, GU Jiawei, NIE Fei, XIAO Liang. Cystine knot peptide's properties and its applications for drug design and molecular engineering[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 481-484,496. doi: 10.3969/j.issn.1006-0111.2016.06.001
Citation: DENG Yuchen, GU Jiawei, NIE Fei, XIAO Liang. Cystine knot peptide's properties and its applications for drug design and molecular engineering[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 481-484,496. doi: 10.3969/j.issn.1006-0111.2016.06.001

胱氨酸结模体多肽的特征及其在药物设计和分子工程中的应用

doi: 10.3969/j.issn.1006-0111.2016.06.001
基金项目: 国家自然科学基金面上项目(81470518)

Cystine knot peptide's properties and its applications for drug design and molecular engineering

  • 摘要: 胱氨酸结(cystine knot,CK)模体是由两对二硫键及其相连的肽链骨架形成的一个内部环以及从环中穿过的第三对二硫键组成的球形结构,广泛存在于真菌、植物、海洋软体动物、昆虫以及蜘蛛等生物的毒素多肽和蛋白质中。CK多肽结构非常稳定、生物活性多样,是一类在药物设计和分子工程研究中的理想模型分子。本文综述了抑制剂胱氨酸结(inhibitor cystine knot,ICK)多肽和环形胱氨酸结(cyclic cystine knot,CCK)多肽两类主要CK毒素的氨基酸序列、拓扑结构、排列组合、人工合成以及空间折叠等特征,并进一步阐述了其在药物设计与分子工程中的应用前景。
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  • 收稿日期:  2015-10-30
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胱氨酸结模体多肽的特征及其在药物设计和分子工程中的应用

doi: 10.3969/j.issn.1006-0111.2016.06.001
    基金项目:  国家自然科学基金面上项目(81470518)

摘要: 胱氨酸结(cystine knot,CK)模体是由两对二硫键及其相连的肽链骨架形成的一个内部环以及从环中穿过的第三对二硫键组成的球形结构,广泛存在于真菌、植物、海洋软体动物、昆虫以及蜘蛛等生物的毒素多肽和蛋白质中。CK多肽结构非常稳定、生物活性多样,是一类在药物设计和分子工程研究中的理想模型分子。本文综述了抑制剂胱氨酸结(inhibitor cystine knot,ICK)多肽和环形胱氨酸结(cyclic cystine knot,CCK)多肽两类主要CK毒素的氨基酸序列、拓扑结构、排列组合、人工合成以及空间折叠等特征,并进一步阐述了其在药物设计与分子工程中的应用前景。

English Abstract

邓宇晨, 顾嘉伟, 聂菲, 肖良. 胱氨酸结模体多肽的特征及其在药物设计和分子工程中的应用[J]. 药学实践与服务, 2016, 34(6): 481-484,496. doi: 10.3969/j.issn.1006-0111.2016.06.001
引用本文: 邓宇晨, 顾嘉伟, 聂菲, 肖良. 胱氨酸结模体多肽的特征及其在药物设计和分子工程中的应用[J]. 药学实践与服务, 2016, 34(6): 481-484,496. doi: 10.3969/j.issn.1006-0111.2016.06.001
DENG Yuchen, GU Jiawei, NIE Fei, XIAO Liang. Cystine knot peptide's properties and its applications for drug design and molecular engineering[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 481-484,496. doi: 10.3969/j.issn.1006-0111.2016.06.001
Citation: DENG Yuchen, GU Jiawei, NIE Fei, XIAO Liang. Cystine knot peptide's properties and its applications for drug design and molecular engineering[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 481-484,496. doi: 10.3969/j.issn.1006-0111.2016.06.001
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