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生物活性肽-单核细胞迁移抑制因子研究进展

程浩 芮耀诚 章越凡 李铁军

程浩, 芮耀诚, 章越凡, 李铁军. 生物活性肽-单核细胞迁移抑制因子研究进展[J]. 药学实践与服务, 2015, 33(1): 17-19,27. doi: 10.3969/j.issn.1006-0111.2015.01.005
引用本文: 程浩, 芮耀诚, 章越凡, 李铁军. 生物活性肽-单核细胞迁移抑制因子研究进展[J]. 药学实践与服务, 2015, 33(1): 17-19,27. doi: 10.3969/j.issn.1006-0111.2015.01.005
CHENG Hao, RUI Yaocheng, ZHANG Yuefan, LI Tiejun. Research progress of bioactive peptide monocyte locomotion inhibitory factor[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 17-19,27. doi: 10.3969/j.issn.1006-0111.2015.01.005
Citation: CHENG Hao, RUI Yaocheng, ZHANG Yuefan, LI Tiejun. Research progress of bioactive peptide monocyte locomotion inhibitory factor[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 17-19,27. doi: 10.3969/j.issn.1006-0111.2015.01.005

生物活性肽-单核细胞迁移抑制因子研究进展

doi: 10.3969/j.issn.1006-0111.2015.01.005
基金项目: 国家科技重大专项项目:防治心肌缺血的抗炎短肽候选化合物研究(2013ZX09103001-005)

Research progress of bioactive peptide monocyte locomotion inhibitory factor

  • 摘要: 单核细胞迁移抑制因子(monocyte locomotion inhibitory factor,MLIF)是阿米巴原虫产生的具有抗炎作用的五肽。体内、外研究发现,MLIF可以发挥抗炎和免疫保护作用,对类风湿关节炎、神经损伤、心肌缺血、脑缺血及痴呆具有良好的保护作用。研究证明MLIF通过NF-κB 和MAPK信号通路调节炎症反应和免疫保护。笔者对MLIF的来源和生物活性做一综述。
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    [17] 杨鹏远,芮耀诚,章越凡.多肽小分子在制备防治缺血性脑血管病药物中的应用[P].中国专利,CN 101361961 A,2009-2-11.
    [18] 章越凡,芮耀诚,李铁军,等.五肽代谢物及其在制备防治缺血性脑血管疾病药物中的应用[P].中国专利,CN 103611149 A,2014-03-05.
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生物活性肽-单核细胞迁移抑制因子研究进展

doi: 10.3969/j.issn.1006-0111.2015.01.005
    基金项目:  国家科技重大专项项目:防治心肌缺血的抗炎短肽候选化合物研究(2013ZX09103001-005)

摘要: 单核细胞迁移抑制因子(monocyte locomotion inhibitory factor,MLIF)是阿米巴原虫产生的具有抗炎作用的五肽。体内、外研究发现,MLIF可以发挥抗炎和免疫保护作用,对类风湿关节炎、神经损伤、心肌缺血、脑缺血及痴呆具有良好的保护作用。研究证明MLIF通过NF-κB 和MAPK信号通路调节炎症反应和免疫保护。笔者对MLIF的来源和生物活性做一综述。

English Abstract

程浩, 芮耀诚, 章越凡, 李铁军. 生物活性肽-单核细胞迁移抑制因子研究进展[J]. 药学实践与服务, 2015, 33(1): 17-19,27. doi: 10.3969/j.issn.1006-0111.2015.01.005
引用本文: 程浩, 芮耀诚, 章越凡, 李铁军. 生物活性肽-单核细胞迁移抑制因子研究进展[J]. 药学实践与服务, 2015, 33(1): 17-19,27. doi: 10.3969/j.issn.1006-0111.2015.01.005
CHENG Hao, RUI Yaocheng, ZHANG Yuefan, LI Tiejun. Research progress of bioactive peptide monocyte locomotion inhibitory factor[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 17-19,27. doi: 10.3969/j.issn.1006-0111.2015.01.005
Citation: CHENG Hao, RUI Yaocheng, ZHANG Yuefan, LI Tiejun. Research progress of bioactive peptide monocyte locomotion inhibitory factor[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 17-19,27. doi: 10.3969/j.issn.1006-0111.2015.01.005
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