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应中央军委要求,2022年9月起,《药学实践杂志》将更名为《药学实践与服务》,双月刊,正文96页;2023年1月起,拟出版月刊,正文64页,数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿!

双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用

高洪元 吴建勇 倪曙民

高洪元, 吴建勇, 倪曙民. 双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用[J]. 药学实践与服务, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
引用本文: 高洪元, 吴建勇, 倪曙民. 双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用[J]. 药学实践与服务, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
GAO Hongyuan, WU Jianyong, NI Shumin. Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
Citation: GAO Hongyuan, WU Jianyong, NI Shumin. Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003

双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用

doi: 10.3969/j.issn.1006-0111.2015.01.003

Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors

  • 摘要: 血脑屏障的存在严重阻碍了脑肿瘤化疗药物向脑内递送。纳米粒、脂质体、胶束等纳米载体可显著增加药物的穿过血脑屏障转运的能力,采用单一或双功能基制备的双级靶向纳米载体还可进一步增加药物的脑内递送及在脑肿瘤病变部位的浓集,从而显著提高脑肿瘤的诊断和治疗效果。笔者主要介绍双级靶向纳米载体的设计思路、靶向功能基的最新研究进展,为相关研究提供参考。
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  • 收稿日期:  2013-11-12
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双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用

doi: 10.3969/j.issn.1006-0111.2015.01.003

摘要: 血脑屏障的存在严重阻碍了脑肿瘤化疗药物向脑内递送。纳米粒、脂质体、胶束等纳米载体可显著增加药物的穿过血脑屏障转运的能力,采用单一或双功能基制备的双级靶向纳米载体还可进一步增加药物的脑内递送及在脑肿瘤病变部位的浓集,从而显著提高脑肿瘤的诊断和治疗效果。笔者主要介绍双级靶向纳米载体的设计思路、靶向功能基的最新研究进展,为相关研究提供参考。

English Abstract

高洪元, 吴建勇, 倪曙民. 双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用[J]. 药学实践与服务, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
引用本文: 高洪元, 吴建勇, 倪曙民. 双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用[J]. 药学实践与服务, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
GAO Hongyuan, WU Jianyong, NI Shumin. Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
Citation: GAO Hongyuan, WU Jianyong, NI Shumin. Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
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