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口服固体自微乳化给药系统的研究进展

赵佳丽 温许 张晶 刘建清 宋洪涛

赵佳丽, 温许, 张晶, 刘建清, 宋洪涛. 口服固体自微乳化给药系统的研究进展[J]. 药学实践与服务, 2014, 32(4): 257-260. doi: 10.3969/j.issn.1006-0111.2014.04.005
引用本文: 赵佳丽, 温许, 张晶, 刘建清, 宋洪涛. 口服固体自微乳化给药系统的研究进展[J]. 药学实践与服务, 2014, 32(4): 257-260. doi: 10.3969/j.issn.1006-0111.2014.04.005
ZHAO Jiali, WEN Xu, ZHANG Jing, LIU Jianqing, SONG Hongtao. Progress on solid self-microemulsifying drug delivery system for oral administration[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 257-260. doi: 10.3969/j.issn.1006-0111.2014.04.005
Citation: ZHAO Jiali, WEN Xu, ZHANG Jing, LIU Jianqing, SONG Hongtao. Progress on solid self-microemulsifying drug delivery system for oral administration[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 257-260. doi: 10.3969/j.issn.1006-0111.2014.04.005

口服固体自微乳化给药系统的研究进展

doi: 10.3969/j.issn.1006-0111.2014.04.005

Progress on solid self-microemulsifying drug delivery system for oral administration

  • 摘要: 目的 对新近发展的固体自微乳化给药系统(S-SMEDDS)文献进行综述。 方法 查阅近年国内外相关文献并进行归纳和总结。 结果 对固体自微乳的载体、固化技术以及缓控释制剂进行了探讨,为研究水难溶性药物的生物利用度及适合药物释放特性的S-SMEDDS技术提供相关参考。 结论 固体自微乳化系统可以显著提高难溶性药物的口服生物利用度,且兼顾了液态自微乳和固体制剂二者的优势,是一个极具潜力的新型制剂。
  • [1] Carrier RL,Miller LA,Ahmed I. The utility of cyclodextrins for enhancing oral bioavailability[J].J Contr Release,2007,123(2):78-99.
    [2] Gursoy RN,Benita S. Self-emulsifying drug delivery systems(SEDDS) for improved oral delivery of lipophilic drugs[J].Biomed Pharmacother,2004,58(3):173-182.
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    [4] Gershanik T,Benita S. Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs[J].Eur J Pharm Biopharm,2000,50(1):179-188.
    [5] 崔 晶.姜黄素固体自微乳化制剂的研究[D].山东:山东大学,2006.
    [6] Yi T,Wan J,Xu H,et al. A new solid self-microemulsifying formulation prepared by spray-drying to improve the oral bioavailability of poorly water soluble drugs[J].Eur J Pharm Biopharm,2008,70(2):439-444.
    [7] Mladen M,Jelena D,Ljiljana D,et al. Characterization and evaluation of solid self-microemulsifying drug delivery systems with porous carriers as systems for improved carbamazepine release[J].Int J Pharm,2012,436(1-2):58-65.
    [8] Nazzal S,Nutan M,Palamakula A,et al. Optimization of a self-nanoemulsified tablet dosage form of ubiquinone using response surface methodology:effect of formulation ingredients[J].Int J Pharm,2002,240(1-2):103-114.
    [9] Kallakunta VR,Bandari S,Jukanti R,et al. Oral self emulsifying powder of lercanidipine hydrochloride:formulation and evaluation[J].Powder Technol,2012,221:375-382.
    [10] Shah AV,Serajuddin ATM. Development of solid self-emulsifying drug delivery system (SEDDS)I:use of poloxamer 188 as both solidifying and emulsifying agent for lpids[J].Pharm Res,2012,29(10):2817-2832.
    [11] Hitesh C.B,Rajendra. CD,Harinath NM,et al. Design and optimization of chlordiazepoxide solid self-microemulsifying drug delivery system[J].Pharm Res,2011,4(2):369-372.
    [12] Balakrishnan P,Lee BJ,Oh DH,et al. Enhanced oral bioavailability of dexibuprofen by a novel solid self-emulsifying drug delivery system (SEDDS)[J].Eur J Pharm Biopharm,2009,72 (3):539-545.
    [13] Abdalla A,Mader K. Preparation and characterization of a self-emulsifying pellet formulation[J].Eur J Pharm Biopharm,2007,66(2):220-226.
    [14] Wang Z,Sun J,Wang Y,et al. Solid self-emulsifying nitrendipine pellets:Preparation and in vitro/in vivo evaluation[J].Int J Pharm,2010,383(1-2):1-6.
    [15] Hu X,Lin C,Chen D,et al. Sirolimus solid self-microemulsifying pellets:formulation development,characterization and bioavailability evaluation[J].Int J Pharm,2012,438(1-2):123-133.
    [16] 易 涛. 固体自微乳化给药系统的研究[D].湖北:华中科技大学,2008.
    [17] 何吉奎. 黄连素自微乳化肠溶胶珠的研究[D].重庆:西南大学,2011.
    [18] Zhang Y,Wang RR,Wu J,et al. Characterization and evaluation of self-microemulsifying sustained-release pellet formulation of puerarin for oral delivery[J].Int J Pharm,2012,427(2):337-344.
    [19] Xie H,Zhou W. Preparation of bi-layered solid self-microemulsifying tablets of tetra-acetylated puerarin[J].Chin J New Drugs,2011,20(9):837-843.
    [20] Patil P,Joshi P,Paradkar A. Effect of formulation variables on preparation and evaluation of gelled self-emulsifying drug delivery system (SEDDS) of ketoprofen[J]. AAPS Pharm Sci Techn,2004,5 (3):E42.
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  • 收稿日期:  2013-02-26
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口服固体自微乳化给药系统的研究进展

doi: 10.3969/j.issn.1006-0111.2014.04.005

摘要: 目的 对新近发展的固体自微乳化给药系统(S-SMEDDS)文献进行综述。 方法 查阅近年国内外相关文献并进行归纳和总结。 结果 对固体自微乳的载体、固化技术以及缓控释制剂进行了探讨,为研究水难溶性药物的生物利用度及适合药物释放特性的S-SMEDDS技术提供相关参考。 结论 固体自微乳化系统可以显著提高难溶性药物的口服生物利用度,且兼顾了液态自微乳和固体制剂二者的优势,是一个极具潜力的新型制剂。

English Abstract

赵佳丽, 温许, 张晶, 刘建清, 宋洪涛. 口服固体自微乳化给药系统的研究进展[J]. 药学实践与服务, 2014, 32(4): 257-260. doi: 10.3969/j.issn.1006-0111.2014.04.005
引用本文: 赵佳丽, 温许, 张晶, 刘建清, 宋洪涛. 口服固体自微乳化给药系统的研究进展[J]. 药学实践与服务, 2014, 32(4): 257-260. doi: 10.3969/j.issn.1006-0111.2014.04.005
ZHAO Jiali, WEN Xu, ZHANG Jing, LIU Jianqing, SONG Hongtao. Progress on solid self-microemulsifying drug delivery system for oral administration[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 257-260. doi: 10.3969/j.issn.1006-0111.2014.04.005
Citation: ZHAO Jiali, WEN Xu, ZHANG Jing, LIU Jianqing, SONG Hongtao. Progress on solid self-microemulsifying drug delivery system for oral administration[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 257-260. doi: 10.3969/j.issn.1006-0111.2014.04.005
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