留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码
x 关闭 永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

青蒿琥酯和熊果酸降血脂作用的最佳配比筛选

叶亚琳,  王玉亮,  王泽剑,  殷明,  辛海量,  张磊

downloadPDF
文章导航 > 药学实践与服务  > 2014 >  32(3): 195-198
叶亚琳, 王玉亮, 王泽剑, 殷明, 辛海量, 张磊. 青蒿琥酯和熊果酸降血脂作用的最佳配比筛选[J]. 药学实践与服务, 2014, 32(3): 195-198. doi: 10.3969/j.issn.1006-0111.2014.03.008
引用本文: 叶亚琳, 王玉亮, 王泽剑, 殷明, 辛海量, 张磊. 青蒿琥酯和熊果酸降血脂作用的最佳配比筛选[J]. 药学实践与服务, 2014, 32(3): 195-198. doi: 10.3969/j.issn.1006-0111.2014.03.008
shu
YE Yalin, WANG Yuliang, WANG Zejian, YIN Ming, XIN Hailiang, ZHANG Lei. Screening the best ratio of artesunate and ursolic acid for lipid-lowering[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 195-198. doi: 10.3969/j.issn.1006-0111.2014.03.008
Citation: YE Yalin, WANG Yuliang, WANG Zejian, YIN Ming, XIN Hailiang, ZHANG Lei. Screening the best ratio of artesunate and ursolic acid for lipid-lowering[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 195-198. doi: 10.3969/j.issn.1006-0111.2014.03.008
shu

青蒿琥酯和熊果酸降血脂作用的最佳配比筛选

doi: 10.3969/j.issn.1006-0111.2014.03.008
  • 1.

    解放军421医院药剂科, 广东 广州 510310

  • 2.

    上海交通大学农业与生物学院, 上海 200240;上海交通大学药学院, 上海 200240

  • 3.

    上海交通大学药学院, 上海 200240

  • 4.

    第二军医大学中医系, 上海 200433

  • 5.

    第二军医大学药学院, 上海 200433

基金项目: 上海市科委中药现代化专项(10DZ1971500).

Screening the best ratio of artesunate and ursolic acid for lipid-lowering

  • 1.

    NO.421 Hospital of PLA, Guangzhou 510310, China

  • 2.

    School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China;School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China

  • 3.

    School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China

  • 4.

    School of Traditional;Chinese Medicine, Second Military Medical University, Shanghai 200433, China

  • 5.

    School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 摘要: 目的 观察青蒿琥酯和熊果酸不同剂量和配伍对大鼠脂质代谢紊乱模型的影响,寻找青蒿琥酯和熊果酸配伍应用的最佳配比。 方法 利用喂养高脂饲料诱导大鼠形成脂质代谢紊乱模型,通过比较各给药组大鼠的血脂水平筛选最佳配比。 结果 实验结果显示,青蒿琥酯(高剂量)+熊果酸(高剂量)均有显著降低TG、CHO、LDL-C作用,可明显升高HDL-C,对H/L值也有一定的升高作用。综合降脂效果优于阳性药非诺贝特,也优于单用同等剂量的青蒿琥酯或熊果酸。各受试样品对大鼠肝功能没有显著影响(P>0.05,与正常组比较)。 结论 青蒿琥酯和熊果酸1:1配比降脂效果最佳,建议剂量为(50+50) mg/kg。
    Abstract: Objective To observe the effect of different doses unilateral and compound of artesunate and ursolic acid on lipid metabolism in rats' model, find out the best ratio of artesunate and ursolic acid. Methods Lipid metabolism disorders model was induced by feeding high fat diet in rat.The best ratio was screened through comparing the lipid level of rats ofdifferent groups. Results The results showed that Artesunate (high dose)+Ursolicacid (high dose) significantly reduced TG, CHO and LDL-C, increased HDL-C and H/L. Lipid-lowering effect was superior the positive drug fenofibrate, but also superior to the same dose of artesunate and ursolic acid alone. No significant effect of each test sample on the rat liver function was observed(P>0.05). Conclusion Artesunate and ursolic acid ratio of 1:1 had the best lipid-lowering effect, and the recommended dose was (50+50) mg/kg.
  • [1] Xu H, He Y, Yang X, et al. Anti-malarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes[J]. Rheumatology,2007,46 (6):920-926.
    [2] Wang JX, Tang W, Zhou R, et al.The new water-soluble artemisinin derivative SM905 ameliorates collagen-induced arthritis by suppression of inflammatory and Th17 responses[J]. Br J Pharmacol, 2008, 153(6): 1303-1310.
    [3] Li WD, Dong YJ, Tu YY, et al.Dihydroarteannuin ameliorates lupus symptom of BXSB mice by inhibiting production of TNF-alpha and blocking the signaling pathway NF-kappa B translocation[J]. Int Immunopharmacol,2006,6 (8): 1243-1250.
    [4] Li B, Zhang R, Li J, et al. Antimalarial artesunate protects sepsis model mice against heat-killed Escherichia coli challenge by decreasing TLR4, TLR9 mRNA expressions and transcription factor NF-kappa B activation[J]. Int Immunopharmacol, 2008, 8(3): 379-389.
    [5] Li T,Chen H,Wei N,et al. Anti-inflammatory and immunomodulatory mechanisms of artemisinin on contact hypersensitivity[J]. Int Immunopharmacol, 2012, 12(1):144-150.
    [6] Hou LF, He SJ, Li X, et al. Oral administration of artemisinin analog SM934 ameliorates lupus syndromes in MRL/lpr mice by inhibiting Th1 and Th17 cell responses[J]. Arthritis Rheum, 2011, 63(8): 2445-2455.
    [7] Cheng C, Ho WE, Goh FY, et al. Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway[J]. PLoS One, 2011, 6(6): e20932.
    [8] Li Y, Wu YL. An over four millennium story behind qinghaosu (artemisinin)-a fantastic antimalarial drug from a traditional Chinese herb[J]. Curr Med Chem, 2003, 10 (21):2197-2223.
    [9] Jayaprakasam B, Olson LK, Schutzki RE, et al. Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas)[J]. J Agric Food Chem,2006,54(1):243-248.
    [10] Somova LO, Nadar A, Rammanan P, et al. Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension[J]. Phytomedicine,2003,10(2-3), 115-121.
    [11] Ullevig SL, Zhao Q, Zamora D, et al. Ursolic acid protects diabetic mice against monocyte dysfunction and accelerated atherosclerosis[J]. Atherosclerosis,2011,219 (2), 409-416.
    [12] 唐克轩,王玉亮,辛海量.降血脂的中药组合物及其制备方法[P]. 中国专利,CN101507727,2009-08-19.
  • [1] 陈炳辰, 佟达丰, 万苗, 闫飞虎, 姚建忠.  UPLC-MS/MS法测定小鼠血浆中紫杉醇脂肪酸酯前药及其药代动力学研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202404082
    [2] 陈炳辰, 王思真, 郭贝贝, 杨峰.  紫杉醇棕榈酸酯的合成及其脂质体的制备与处方研究 . 药学实践与服务, 2024, 42(): 1-7. doi: 10.12206/j.issn.2097-2024.202404062
    [3] 杨嘉宁, 赵一颖, 肖伟.  七味脂肝方对非酒精性脂肪性肝炎动物模型的药效学评价 . 药学实践与服务, 2024, 42(): 1-10. doi: 10.12206/j.issn.2097-2024.202404096
    [4] 赖立勇, 夏天爽, 徐圣焱, 蒋益萍, 岳小强, 辛海量.  中药青蒿抗氧化活性的谱效关系研究 . 药学实践与服务, 2024, 42(5): 203-210, 216. doi: 10.12206/j.issn.2097-2024.202211012
    [5] 毛智毅, 王筱燕, 陈晓颖, 汤逸斐.  度拉糖肽联合二甲双胍对肥胖型2型糖尿病患者机体代谢、体脂成分及血清脂肪因子的影响 . 药学实践与服务, 2024, 42(7): 305-309. doi: 10.12206/j.issn.2097-2024.202305032
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  2646
  • HTML全文浏览量:  290
  • PDF下载量:  72
  • 被引次数: 0
出版历程
  • 收稿日期:  2013-05-01
  • 修回日期:  2013-09-12

青蒿琥酯和熊果酸降血脂作用的最佳配比筛选

doi: 10.3969/j.issn.1006-0111.2014.03.008
  • 1. 解放军421医院药剂科, 广东 广州 510310
  • 2. 上海交通大学农业与生物学院, 上海 200240;上海交通大学药学院, 上海 200240
  • 3. 上海交通大学药学院, 上海 200240
  • 4. 第二军医大学中医系, 上海 200433
  • 5. 第二军医大学药学院, 上海 200433
    • 基金项目:  上海市科委中药现代化专项(10DZ1971500).
  • 收稿日期: 2013-05-01
  • 修回日期: 2013-09-12

摘要: 目的 观察青蒿琥酯和熊果酸不同剂量和配伍对大鼠脂质代谢紊乱模型的影响,寻找青蒿琥酯和熊果酸配伍应用的最佳配比。 方法 利用喂养高脂饲料诱导大鼠形成脂质代谢紊乱模型,通过比较各给药组大鼠的血脂水平筛选最佳配比。 结果 实验结果显示,青蒿琥酯(高剂量)+熊果酸(高剂量)均有显著降低TG、CHO、LDL-C作用,可明显升高HDL-C,对H/L值也有一定的升高作用。综合降脂效果优于阳性药非诺贝特,也优于单用同等剂量的青蒿琥酯或熊果酸。各受试样品对大鼠肝功能没有显著影响(P>0.05,与正常组比较)。 结论 青蒿琥酯和熊果酸1:1配比降脂效果最佳,建议剂量为(50+50) mg/kg。

English Abstract

叶亚琳, 王玉亮, 王泽剑, 殷明, 辛海量, 张磊. 青蒿琥酯和熊果酸降血脂作用的最佳配比筛选[J]. 药学实践与服务, 2014, 32(3): 195-198. doi: 10.3969/j.issn.1006-0111.2014.03.008
引用本文: 叶亚琳, 王玉亮, 王泽剑, 殷明, 辛海量, 张磊. 青蒿琥酯和熊果酸降血脂作用的最佳配比筛选[J]. 药学实践与服务, 2014, 32(3): 195-198. doi: 10.3969/j.issn.1006-0111.2014.03.008
shu
YE Yalin, WANG Yuliang, WANG Zejian, YIN Ming, XIN Hailiang, ZHANG Lei. Screening the best ratio of artesunate and ursolic acid for lipid-lowering[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 195-198. doi: 10.3969/j.issn.1006-0111.2014.03.008
Citation: YE Yalin, WANG Yuliang, WANG Zejian, YIN Ming, XIN Hailiang, ZHANG Lei. Screening the best ratio of artesunate and ursolic acid for lipid-lowering[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(3): 195-198. doi: 10.3969/j.issn.1006-0111.2014.03.008
shu

    全文HTML

参考文献 (12)

目录

    /

    返回文章
    返回

    版权所有：《药学实践与服务》编辑委员会

    主管、主办: 中国人民解放军海军军医大学地址: 上海市杨浦区国和路325号邮政编码: 200433

    电话: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计