留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

应中央军委要求,2022年9月起,《药学实践杂志》将更名为《药学实践与服务》,双月刊,正文96页;2023年1月起,拟出版月刊,正文64页,数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿!

微针透皮给药系统应用研究进展

万展 周剑 韩美娜 杨峰

万展, 周剑, 韩美娜, 杨峰. 微针透皮给药系统应用研究进展[J]. 药学实践与服务, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
引用本文: 万展, 周剑, 韩美娜, 杨峰. 微针透皮给药系统应用研究进展[J]. 药学实践与服务, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
WAN Zhan, ZHOU Jian, HAN Mei-na, YANG Feng. Progress on micro-needles transdermal drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
Citation: WAN Zhan, ZHOU Jian, HAN Mei-na, YANG Feng. Progress on micro-needles transdermal drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002

微针透皮给药系统应用研究进展

doi: 10.3969/j.issn.1006-0111.2012.02.002
基金项目: 上海高校选拔培养优秀青年教师科研专项基金(egd09014).

Progress on micro-needles transdermal drug delivery system

  • 摘要: 微针透皮给药系统是近年来透皮给药系统研究的热点。微针透皮给药系统具有注射给药和透皮给药的双重优势,具有快速、方便、无痛等众多优点,研究表明可以显著提高药物透皮速率和吸收量,特别是在蛋白质、多肽、DNA和RNA等大分子物质的透皮制剂研究领域表现出良好的效果和应用前景,本文对微针透皮给药系统应用研究的最新进展进行了综述。随着微针加工技术、载药技术和应用研究的不断深入,微针透皮技术在临床领域将会有更广泛的应用。
  • [1] Henry S, McAllister DV, Allen MG, et al. Microfabricated microneedles : a novel approach to transdermal drug delivery[J]. J Pharmacol Sci,1998,87(8):922.
    [2] Mark RP, Robert L. Transdermal drug delivery[J].Nat Biotechnol,2008,26(11):1261.
    [3] Kalluri H, Banga AK. Transdermal delivery of proteins[J]. AAPS Pharmscitech, 2011.12(1):431.
    [4] Zhu QY,Zarnitsyn VG,Ye L,et al.Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge[J].Proc Natl Acad Sci USA,2009,106(19):7968.
    [5] Kaushik S, Hord AH, Denson DD, et al. Lack of pain associated with microfabricated microneedles[J]. Anesth.Analg,2001,92(2):502.
    [6] Ding Z,Riet V,Romeijn S,et al.Immune modulation by adjuvants combined with diphtheria toxoid administered topically in BALB/c mice after microneedle array pretreatment [J].Pharm Res,2009,26(7):163.
    [7] Sullivan SP, Koutsonanos DG,Del Pilar Martin M, et al.Dissolving polymer microneedle patches for influenza vaccination[J].Nat Med,2010,16(8):915.
    [8] Quan FS,Kim YC, Compans RW,et al. Dose sparing enabled by skin immunization with influenza virus-like particle vaccine using microneedles[J].J Controlled Release,2010,147(3):326.
    [9] Hiraishi Y,Nandakumar S,Choi SO,et al.Bacillus Calmette-Guerin vaccination using a microneedle patch[J].Vaccine,2011,29(14):2626.
    [10] Nordquist L,Roxhed N,Griss P,et al.ovel microneedle patches for active insulin delivery are efficientin maintaining glycaemic control:an initial comparison with ubcutaneous administration[J].Pharm Res,2007,24(7):1381.
    [11] Chen HB, Zhu HD,Zheng JN,et al. Iontophoresis-driven penetration of nanovesicles through microneedle induced skin microchannels for enhancing transdermal delivery of insulin[J]. J Controlled Release,2009,139(1):63.
    [12] Gupta J,Felner EI,Prausnitz MR.Rapid pharmacokinetics of intradermal insulin administered using microneedles in type 1 diabetes subjects[J].Diabetes Technol Ther,2011 13(4):451.
    [13] You X,Chang Jong-hyeon,Ju Byeong-Kwon,et al.Rapidly dissolving fibroin microneedles for transdermal drug delivery[J]. Mater Sci Eng.,C 2011,31(8):1632.
    [14] Qin G, Gao Y, Wu Y,et al.Simultaneous basal-bolus delivery of fast-acting insulin and its significance in diabetes management[J].Nanomedicine:NBM 2011,doi: 10.1016/j.nano.2011.05.017.
    [15] Harvey AJ,Kaestner SA,Sutter DE,et al.Microneedle-based intradermal delivery enables rapid lymphatic uptake and distribution of protein drugs[J].Pharm Res,2011,28(1):107.
    [16] Pearton M, Allender C, Brain K,et al.Gene delivery to the epidermal cells of human skin explants using microfabricated microneedles and hydrogel formulations[J]. Pharm Res,2008,25(2):407.
    [17] Gill HS, Soderholm J,Prausnitz MR,et al.Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine[J]. Gene Ther,2010,17(6):811.
    [18] Chen X,Kask AS,Crichton ML,et al.Improved DNA vaccination by skin-targeted delivery using dry-coated densely-packed microprojection arrays[J].J Controlled Release,2010,148(3):321.
    [19] Kask AS,Chen X,Marshak JO,et al.DNA vaccine delivery by densely-packed and short microprojection arrays to skin protects against vaginal HSV-2 challenge[J].Vaccine,2010,28(47):7483.
    [20] Gonzalez-Gonzalez E, Speaker TJ,Hickerson RP,et al.Silencing of reporter gene expression in skin using siRNAs and Expression of plasmid DNA delivered by a soluble protrusion array device[J]. Mol Ther,2010,18(9):1667.
    [21] Donnelly RF,Morrow DI,Fay F,et al.Microneedle-mediated intradermal nanoparticle delivery:potential for enhanced local administration of hydrophobic pre-formed photosensitisers[J].Photodiagnosis Photodyn Ther,2010,7(4):222.
    [22] Ito Y,Murano H,Hamasaki N,et al.Incidence of low bioavailability of leuprolide acetate after percutaneous administration to rats by dissolving microneedles[J].Int J Pharm,2011,407(1-2):126.
    [23] Baek C,Han M,Min J,et al.Local transdermal delivery of phenylephine to the anal sphincter muscle using microneedles[J].J Controlled Release,2011,154(2):138.
    [24] Milewski M,Yerramreddy TR,Ghosh P,et al.In vitro permeation of apegylated naltrexone prodrug across microneedle-treated skin[J].J Controlled Release,2010,146(1):37.
  • 加载中
计量
  • 文章访问数:  3698
  • HTML全文浏览量:  230
  • PDF下载量:  1243
  • 被引次数: 0
出版历程
  • 收稿日期:  2011-09-01
  • 修回日期:  2011-12-06

微针透皮给药系统应用研究进展

doi: 10.3969/j.issn.1006-0111.2012.02.002
    基金项目:  上海高校选拔培养优秀青年教师科研专项基金(egd09014).

摘要: 微针透皮给药系统是近年来透皮给药系统研究的热点。微针透皮给药系统具有注射给药和透皮给药的双重优势,具有快速、方便、无痛等众多优点,研究表明可以显著提高药物透皮速率和吸收量,特别是在蛋白质、多肽、DNA和RNA等大分子物质的透皮制剂研究领域表现出良好的效果和应用前景,本文对微针透皮给药系统应用研究的最新进展进行了综述。随着微针加工技术、载药技术和应用研究的不断深入,微针透皮技术在临床领域将会有更广泛的应用。

English Abstract

万展, 周剑, 韩美娜, 杨峰. 微针透皮给药系统应用研究进展[J]. 药学实践与服务, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
引用本文: 万展, 周剑, 韩美娜, 杨峰. 微针透皮给药系统应用研究进展[J]. 药学实践与服务, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
WAN Zhan, ZHOU Jian, HAN Mei-na, YANG Feng. Progress on micro-needles transdermal drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
Citation: WAN Zhan, ZHOU Jian, HAN Mei-na, YANG Feng. Progress on micro-needles transdermal drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
参考文献 (24)

目录

    /

    返回文章
    返回