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比较万古霉素持续输注与间断输注引起肾毒性的荟萃分析

郑丽丽 轩辕欢 姜倩 范芳芳 姚莉 赵生俊

郑丽丽, 轩辕欢, 姜倩, 范芳芳, 姚莉, 赵生俊. 比较万古霉素持续输注与间断输注引起肾毒性的荟萃分析[J]. 药学实践与服务, 2018, 36(2): 136-139,146. doi: 10.3969/j.issn.1006-0111.2018.02.009
引用本文: 郑丽丽, 轩辕欢, 姜倩, 范芳芳, 姚莉, 赵生俊. 比较万古霉素持续输注与间断输注引起肾毒性的荟萃分析[J]. 药学实践与服务, 2018, 36(2): 136-139,146. doi: 10.3969/j.issn.1006-0111.2018.02.009
ZHENG Lili, XUAN Yuanhuan, JIANG Qian, FAN Fangfang, YAO Li, ZHAO Shengjun. Meta-analysis on renal toxicity of vancomycin given by continuous infusion vs intermittent infusion[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(2): 136-139,146. doi: 10.3969/j.issn.1006-0111.2018.02.009
Citation: ZHENG Lili, XUAN Yuanhuan, JIANG Qian, FAN Fangfang, YAO Li, ZHAO Shengjun. Meta-analysis on renal toxicity of vancomycin given by continuous infusion vs intermittent infusion[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(2): 136-139,146. doi: 10.3969/j.issn.1006-0111.2018.02.009

比较万古霉素持续输注与间断输注引起肾毒性的荟萃分析

doi: 10.3969/j.issn.1006-0111.2018.02.009
基金项目: 国家自然科学基金(81460603)

Meta-analysis on renal toxicity of vancomycin given by continuous infusion vs intermittent infusion

  • 摘要: 目的 比较万古霉素两种给药方式(持续输注与间断输注)引起的肾毒性。 方法 计算机检索Embase、PubMed、The Cochrane Register of Controlled Trials和CBM、CNKI、万方数据库。采用Cochrane协作网提供的Revman5.2软件进行Meta分析。 结果 共纳入2篇随机对照试验(RCT)和8篇观察性研究,共纳入患者1 764例,其中持续输注1 037例,间断输注727例。持续输注与间断输注引起的肾毒性发生率无显著性差异(P>0.05)。 结论 万古霉素持续输注较间断输注不能有效降低肾毒性的发生率。
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    [4] 陈春辉,李光辉.美国感染病学会治疗成人及儿童甲氧西林耐药金黄色葡萄球菌感染临床实践指南[J].中国感染与化疗杂志,2011,11(6):428-435.
    [5] Rybak M, Lomaestro B, Rotschafer JC, et al.Therapeutic monitoring of vancomycin in adult patients:a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists[J]. Am J Health Syst Pharm,2008,66(1):82-98.
    [6] van Hal SJ, Paterson DL, Lodise TP. Systematic review and meta-analysis of vancomycin-induced nephrotoxicity associated with dosing schedules that maintain troughs between 15 and 20 milligrams per liter[J]. Antimicrob Agents Chemother, 2013,57(2):734-744.
    [7] 黄榜江,肖政,汪成琼,等.我国慢性阻塞性肺病院内真菌感染特征及高危药物因素的Meta分析[J].实用医学杂志,2015,31(1):110-115.
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    [13] Vuagnat A, Stern R, Lotthe A, et al. High dose vancomycin for osteomyelitis:continuous vs. intermittent infusion[J]. J Clin Pharm Ther,2004,29(4):351-357.
    [14] Hutschala D, Kinstner C, Skhirdladze K, et al. Influence of vancomycin on renal function in critically ill patients after cardiac surgery:continuous versus intermittent infusion[J]. Anesthesiology,2009,111(2):356-365.
    [15] Ingram PR, Lye DC, Fisher DA, et al. Nephrotoxicity of continuous versus intermittent infusion of vancomycin in outpatient parenteral antimicrobial therapy[J]. Int J Antimicrob Agents, 2009,34(6):570-574.
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  • 收稿日期:  2017-06-30
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比较万古霉素持续输注与间断输注引起肾毒性的荟萃分析

doi: 10.3969/j.issn.1006-0111.2018.02.009
    基金项目:  国家自然科学基金(81460603)

摘要: 目的 比较万古霉素两种给药方式(持续输注与间断输注)引起的肾毒性。 方法 计算机检索Embase、PubMed、The Cochrane Register of Controlled Trials和CBM、CNKI、万方数据库。采用Cochrane协作网提供的Revman5.2软件进行Meta分析。 结果 共纳入2篇随机对照试验(RCT)和8篇观察性研究,共纳入患者1 764例,其中持续输注1 037例,间断输注727例。持续输注与间断输注引起的肾毒性发生率无显著性差异(P>0.05)。 结论 万古霉素持续输注较间断输注不能有效降低肾毒性的发生率。

English Abstract

郑丽丽, 轩辕欢, 姜倩, 范芳芳, 姚莉, 赵生俊. 比较万古霉素持续输注与间断输注引起肾毒性的荟萃分析[J]. 药学实践与服务, 2018, 36(2): 136-139,146. doi: 10.3969/j.issn.1006-0111.2018.02.009
引用本文: 郑丽丽, 轩辕欢, 姜倩, 范芳芳, 姚莉, 赵生俊. 比较万古霉素持续输注与间断输注引起肾毒性的荟萃分析[J]. 药学实践与服务, 2018, 36(2): 136-139,146. doi: 10.3969/j.issn.1006-0111.2018.02.009
ZHENG Lili, XUAN Yuanhuan, JIANG Qian, FAN Fangfang, YAO Li, ZHAO Shengjun. Meta-analysis on renal toxicity of vancomycin given by continuous infusion vs intermittent infusion[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(2): 136-139,146. doi: 10.3969/j.issn.1006-0111.2018.02.009
Citation: ZHENG Lili, XUAN Yuanhuan, JIANG Qian, FAN Fangfang, YAO Li, ZHAO Shengjun. Meta-analysis on renal toxicity of vancomycin given by continuous infusion vs intermittent infusion[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(2): 136-139,146. doi: 10.3969/j.issn.1006-0111.2018.02.009
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