L-2-(N-叔丁氧酰基)-3′,4′-二甲氧基苯丙氨酸乙酯的合成
An efficient method for the synthesis of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester
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摘要: 目的:改进L-2-(N-叔丁氧酰基)-3′,4′-二甲氧基苯丙氨酸乙酯的合成工艺。方法:以左旋多巴为起始原料,采用"半分离纯化"的制备方法进行合成,并对处理工艺进行优化。结果:通过此法制备步骤简单,后处理容易,可有效减少原料及中间体的氧化程度。总收率达到45.4%。结论:这是一种易于操作、适合规模化生产的制备工艺。
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关键词:
- 左旋多巴 /
- L-2-(N-叔丁氧酰基)-3′,4′-二甲氧基苯丙氨酸乙酯 /
- 合成
Abstract: Objective :To improve the synthetic process of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester. Methods :The target molecular was prepared from L-DOPA by using a "half-purified" method.The disposition technics were optimized. Results :The synthetic process offers a simple,easy disposal procedure which can effectively reduce the oxidation of raw material and intermediate.The overall yield is 45.4%. Conclusion :The optimized synthetic process is easy to operate and suitable for large-scale production.-
Key words:
- L-DOPA /
- L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester /
- synthesis
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