国产加替沙星与左氧氟沙星双盲随机对照治疗细菌感染的Meta分析
A meta-analysis of treatment of bacterial infections with double-blind randomized clinical study of indigenous gatifloxcin versus levofloxacin
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摘要: 目的: 探讨国产加替沙星治疗细菌感染的有效性和安全性。 方法: 按照系统评价的要求全面检索了中国数字医院图书馆(www.chkd.cnki.net)、中国医学科学院的中国生物医学文献光盘数据库(CBM disk),对符合纳入标准的18篇文献共计2253名患者进行了Meta分析。 结果: 国产加替沙星组临床有效率与左氧氟沙星组临床有效率OR合并值1.42(95%CI为1.03~1.98),Z=2.11,P=0.03,差异有显著性;痊愈率、细菌清除率和不良反应发生率没有显著差异。 结论: 国产加替沙星治疗细菌感染的有效率比左氧氟沙星高。Abstract: Objective: To estimate the efficacy and safety of indigenous gatifloxacin and levofloxacin on bacterial infection. Methods: According to the requirements of Cochrane systematic review,a thorough literature search was performed among Chinese digital Hospital Library(www.chkd.cnki.net) and Chinese Biomedical Literature Disk Database(CBM disk).A meta analysis was per- formed on a total of 2 253 patients involved in 18 papers which met the inclusion criteria. Results: The clinical effective rate of indige- nous gatifloxacin treatment group versus levofloxacin treatment group was found between the two groups( OR 1.42,95% CI 1.03~1.98,Z=2.11 P=0.03) have significant difference.Clinical cure rates、corresponding bacterial eradication rates and adverse reac- tion rates have no significant difference. Conclusions: Indigenous gatifloxacin treatment bacterial infection effectivenessis higher than levofloxacin.
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Key words:
- gastifloxacin /
- levofloxacin /
- double-blind randomized /
- bacterial infections /
- meta-analysis
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