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UGT1A1基因多态性对药物代谢和临床作用影响的进展

张喆 蔡卫民

张喆, 蔡卫民. UGT1A1基因多态性对药物代谢和临床作用影响的进展[J]. 药学实践与服务, 2018, 36(6): 488-492. doi: 10.3969/j.issn.1006-0111.2018.06.003
引用本文: 张喆, 蔡卫民. UGT1A1基因多态性对药物代谢和临床作用影响的进展[J]. 药学实践与服务, 2018, 36(6): 488-492. doi: 10.3969/j.issn.1006-0111.2018.06.003
ZHANG Zhe, CAI Weimin. Research progress on the effect of UGT1A1 gene polymorphisms on drug metabolism and clinical efficacy[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 488-492. doi: 10.3969/j.issn.1006-0111.2018.06.003
Citation: ZHANG Zhe, CAI Weimin. Research progress on the effect of UGT1A1 gene polymorphisms on drug metabolism and clinical efficacy[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 488-492. doi: 10.3969/j.issn.1006-0111.2018.06.003

UGT1A1基因多态性对药物代谢和临床作用影响的进展

doi: 10.3969/j.issn.1006-0111.2018.06.003

Research progress on the effect of UGT1A1 gene polymorphisms on drug metabolism and clinical efficacy

  • 摘要: UGT1A1基因是参与人体代谢循环的重要基因,随着药物基因组学的发展,发现其基因多态性与某些药物代谢水平相关,进而影响疾病的发生、发展及治疗等诸多方面。随着研究进展,UGT1A1的底物在不断扩展,包括胆红素、雌激素、伊立替康及其他一些药物已有研究。研究UGT1A1基因多态性对药物代谢情况的影响,在临床疾病的诊治、预后判断及药物不良反应等方面有重要的指导意义。
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    [2] 李登,王潞. UGT1A1基因多态性与伊立替康致迟发性腹泻及治疗的研究进展[J]. 科技信息, 2014(3):271-272.
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    [5] 侯慧轩. 亚洲人群晚期结直肠癌UGT1A1基因多态性与伊立替康相关毒性的meta分析[D]. 乌鲁木齐:新疆医科大学, 2016.
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    [8] FUKUDA M,OKUMURA M,IWAKIRI T,et al. Relationship between UGT1A1*27 and UGT1A1*7 polymorphisms and irinotecan-related toxicities in patients with lung cancer[J]. Thorac Cancer, 2018, 9(1):51-58.
    [9] MCLEOD HL,SARGENT DJ,MARSH S,et al. Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer:results from North American gastrointestinal intergroup trial N9741[J]. J Clin Oncol, 2010, 28(20):3227-3233.
    [10] 衡雪源,车峰远,来向阳,等. 中国部分地区肿瘤患者UGT1A1*28和UGT1A1*6位点基因多态性分布的差异研究[J]. 2016, 19(30):3705-3710.
    [11] LI GY,DUAN JF,LI WJ,et al. DPYD*2A/*5A/*9A and UGT1A1*6/*28 polymorphisms in Chinese colorectal cancer patients[J]. J Cancer Res Ther, 2016, 12(2):782-786.
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    [13] 栾家杰,刘俊,汪琳,等. 安徽地区汉族人群肿瘤患者UGT1A1*6基因多态性分布的差异性研究[J]. 中国药理学通报, 2018, 34(6):857-862.
    [14] NAKAMURA Y,SODA H,OKA M,et al. Randomized phase Ⅱ trial of irinotecan with paclitaxel or gemcitabine for non-small cell lung cancer:association of UGT1A1*6 and UGT1A1*27 with severe neutropenia[J]. J Thorac Oncol, 2011, 6(1):121-127.
    [15] RADOI VE,URSU RI,POENARU E,et al. Frequency of the UGT1A1*28 polymorphism in a Romanian Cohort of Gilbert syndrome individuals[J]. J Gastrointestin Liver Dis, 2017, 26(1):25-28.
    [16] MAZUR-KOMINEK K,ROMANOWSKI T,BIELAWSKI K,et al. Association between uridin diphosphate glucuronosylotransferase 1A1(UGT1A1) gene polymorphism and neonatal hyperbilirubinemia.[J]. Acta Biochim Pol, 2017,64(2):351-356.
    [17] KUO S,YANG S,YOU S,et al. Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer[J]. Oncotarget, 2017, 8(13):20925-20938.
    [18] ADEGOKE OJ,SHU XO,GAO YT,et al. Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1(UGT1A1) and risk of breast cancer[J]. Breast Cancer Res Treat, 2004, 85(3):239-245.
    [19] 田玉廷. UGT1A1基因多态性与乳腺癌发病风险的关系[D]. 石家庄:河北医科大学,2013.
    [20] DEMING SL,ZHENG W,XU WH,et al. UGT1A1 genetic polymorphisms, endogenous estrogen exposure, soy food intake, and endometrial cancer risk[J]. Cancer Epidemiol Biomark Prev, 2008, 17(3):563-570.
    [21] YOKOTA M,HIRASAWA A,MAKITA K,et al. Polymorphisms of estrogen metabolism-related genes ESR1, UGT2B17, and UGT1A1 are not associated with osteoporosis in surgically menopausal Japanese women.[J]. Menop Rev, 2015, 14(3):161-167.
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    [24] 张君孝,王晨亮,黄美近,等. UGT1A1基因多态性与转移性结直肠癌伊立替康化疗毒性及疗效的关系[J]. 中国病理生理杂志, 2012,28(5):823-828.
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    [30] XU CL,TANG XS,QU YL,et al. UGT1A1 gene polymorphism is associated with toxicity and clinical efficacy of irinotecan-based chemotherapy in patients with advanced colorectal cancer[J]. Cancer Chemother Pharmacol, 2016, 78(1):119-130.
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    [35] IGARASHI R,INOUE T,FUJIYAMA N,et al. Contribution of UGT1A1 genetic polymorphisms related to axitinib pharmacokinetics to safety and efficacy in patients with renal cell carcinoma[J]. Med Oncol, 2018, 35(4):51.
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  • 收稿日期:  2018-07-17
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UGT1A1基因多态性对药物代谢和临床作用影响的进展

doi: 10.3969/j.issn.1006-0111.2018.06.003

摘要: UGT1A1基因是参与人体代谢循环的重要基因,随着药物基因组学的发展,发现其基因多态性与某些药物代谢水平相关,进而影响疾病的发生、发展及治疗等诸多方面。随着研究进展,UGT1A1的底物在不断扩展,包括胆红素、雌激素、伊立替康及其他一些药物已有研究。研究UGT1A1基因多态性对药物代谢情况的影响,在临床疾病的诊治、预后判断及药物不良反应等方面有重要的指导意义。

English Abstract

张喆, 蔡卫民. UGT1A1基因多态性对药物代谢和临床作用影响的进展[J]. 药学实践与服务, 2018, 36(6): 488-492. doi: 10.3969/j.issn.1006-0111.2018.06.003
引用本文: 张喆, 蔡卫民. UGT1A1基因多态性对药物代谢和临床作用影响的进展[J]. 药学实践与服务, 2018, 36(6): 488-492. doi: 10.3969/j.issn.1006-0111.2018.06.003
ZHANG Zhe, CAI Weimin. Research progress on the effect of UGT1A1 gene polymorphisms on drug metabolism and clinical efficacy[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 488-492. doi: 10.3969/j.issn.1006-0111.2018.06.003
Citation: ZHANG Zhe, CAI Weimin. Research progress on the effect of UGT1A1 gene polymorphisms on drug metabolism and clinical efficacy[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(6): 488-492. doi: 10.3969/j.issn.1006-0111.2018.06.003
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