留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

应中央军委要求,2022年9月起,《药学实践杂志》将更名为《药学实践与服务》,双月刊,正文96页;2023年1月起,拟出版月刊,正文64页,数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿!

西沙群岛隋氏蒂壳海绵Theonella swinhoei的化学成分研究

李彦赟 徐彬 程春伟 林厚文 杨帆

李彦赟, 徐彬, 程春伟, 林厚文, 杨帆. 西沙群岛隋氏蒂壳海绵Theonella swinhoei的化学成分研究[J]. 药学实践与服务, 2018, 36(1): 55-60. doi: 10.3969/j.issn.1006-0111.2018.01.011
引用本文: 李彦赟, 徐彬, 程春伟, 林厚文, 杨帆. 西沙群岛隋氏蒂壳海绵Theonella swinhoei的化学成分研究[J]. 药学实践与服务, 2018, 36(1): 55-60. doi: 10.3969/j.issn.1006-0111.2018.01.011
LI Yanyun, XU Bin, CHENG Chunwei, LIN Houwen, YANG Fan. Chemical constituents from the marine sponge Theonella swinhoei[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 55-60. doi: 10.3969/j.issn.1006-0111.2018.01.011
Citation: LI Yanyun, XU Bin, CHENG Chunwei, LIN Houwen, YANG Fan. Chemical constituents from the marine sponge Theonella swinhoei[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 55-60. doi: 10.3969/j.issn.1006-0111.2018.01.011

西沙群岛隋氏蒂壳海绵Theonella swinhoei的化学成分研究

doi: 10.3969/j.issn.1006-0111.2018.01.011
基金项目: 国家自然科学基金项目(U1605221,41476121,81602981)

Chemical constituents from the marine sponge Theonella swinhoei

  • 摘要: 目的 对采自西沙群岛的隋氏蒂壳海绵(Theonella swinhoei)的次生代谢产物进行研究。 方法 运用溶剂分步萃取以及减压柱色谱、中压柱色谱、薄层色谱、Sephadex LH-20凝胶柱色谱、高效液相色谱及液质联用等多种色谱分离与分析手段,对隋氏蒂壳海绵的石油醚和二氯甲烷萃取部位进行分离纯化,通过化合物的理化性质及波谱数据,结合文献进行结构鉴定。 结果 共分离得到8个化合物,分别鉴定为cholest-7-ene-3β,5α,6β-triol( 1 ),ergosta-7,22-diene-3β,5α,6β-triol( 2 ),25-norcycloartane-3β,6α,16β,24-tetraol( 3 ),sinuflexibilin D( 4 ),14-deoxycrassin( 5 ),N-(2-phenylethyl)-(9Z)-tetradecanamide( 6 ),N-(2-phenylethyl)-tetradecanamide( 7 ),7,8-dimethyl-isoalloxazine( 8 )。 结论 化合物 1 ~ 7 首次从Theonella属海绵中分离得到。
  • [1] 釜野德明,张惠平. 海洋抗肿瘤活性大环内酯类化合物化学成分研究近况[J].天然产物研究与开发,1992,4(3):48-72.
    [2] Sinisi A, Calcinai B, Cerrano C, et al. New tridecapeptides of the theonellapeptolide family from the Indonesian sponge Theonella swinhoei[J]. Beilstein J Org Chem, 2013, 9:1643-1651.
    [3] Gong J, Sun P, Jiang N, et al. New steroids with a rearranged skeleton as (h)P300 inhibitors from the sponge Theonella swinhoei[J]. Org Lett, 2014, 16(8):2224-2227.
    [4] Gerwick WH, Moore BS. Lessons from the past and charting the future of marine natural products drug discovery and chemical biology[J]. Chem Biol, 2012, 19(1):85-98.
    [5] Keren R, Lavy A, Mayzel B, et al. Culturable associated-bacteria of the sponge Theonella swinhoei show tolerance to high arsenic concentrations[J]. Front Microbiol, 2015, 6:154-163.
    [6] Keren R, Mayzel B, Lavy A. Sponge-associated bacteria mineralize arsenic and barium on intracellular vesicles[J]. Nat Commun, 2017, 8:14393-14405.
    [7] Wilson MC, Mori T, Ruckert C, et al. An environmental bacterial taxon with a large and distinct metabolic repertoire[J]. Nature, 2014, 506(7486):58-62.
    [8] Jin L, Liu F, Sun W, et al. Pezizomycotina dominates the fungal communities of South China sea sponges Theonella swinhoei and Xestospongia testudinaria[J]. FEMS Microbiol Ecol, 2014, 90(3):935-945.
    [9] 张红军. 三种西沙海绵化学成分和生物活性研究[D]. 上海:第二军医大学, 2009.
    [10] Zhang HJ, Yi YH, Lin HW. Oxygenated 4-methylidene sterols from the south China sea sponge Theonella swinhoei[J]. Helv Chim Acta, 2010, 93(6):1120-1126.
    [11] Zipser B, Bradford JJ, Hollingsworth RI. Cholesterol and its derivatives, are the principal steroids isolated from the leech species Hirudo medicinalis[J]. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol, 1998, 120(2):269-282.
    [12] Musumeci D, Sica D. CH(3)ReO(3)-catalyzed oxidation of cholesta-5,7-dien-3beta-yl acetate with the urea-hydrogen peroxide adduct under various conditions. Synthesis of the natural epoxy sterol 9alpha,11alpha-epoxy-5alpha-cholest-7-en-3beta,5,6beta-triol[J]. Steroids, 2002, 67(7):661-668.
    [13] 高慧敏, 吴喜燕, 李宗云,等. 蟾衣化学成分及体外抗肿瘤活性研究[J]. 中国中药杂志, 2011, 36(16):2207-2210.
    [14] Kwon HC, Zee SD, Cho SY, et al. Cytotoxic ergosterols from Paecilomyces sp. J300[J]. Arch Pharm Res, 2002, 25(6):851-855.
    [15] Agzamova MA, Isaev MI. Triterpene glycosides of Astragalus and their genins. LVI. cyclopycnanthoside-a new cycloartane glycoside[J]. Chem of Nat Compd, 1998, 34(2):155-159.
    [16] Yang B, Zhou X, Huang H, et al. New cembrane diterpenoids from a Hainan soft coral Sinularia sp[J]. Mar Drugs, 2012, 10(9):2023-2032.
    [17] Rodr guez AD, Mart nez N. Marine antitumor agents:14-deoxycrassin and pseudoplexaurol, new cembranoid diterpenes from the Caribbean gorgonian Pseudoplexaura porosa[J]. Experientia, 49(2):179-181.
    [18] Shih HJ, Tseng YJ, Huang CY, et al. Cytotoxic and anti-inflammatory diterpenoids from the Dongsha Atoll soft coral Sinularia flexibilis[J]. Tetrahedron, 2012, 68(1):244-249.
    [19] Boeroeczky K, Laatsch H, Wagnerdoebler I, et al. Cluster analysis as selection and dereplication tool for the identification of new natural compounds from large sample sets[J]. Chem Biodivers, 2006, 3(6):622-634.
    [20] Hill AJ, Hall GE. Some sulfanilamide derivatives of the isoquinoline series[J]. J Am Chem Soc, 1952, 74(3):666-668.
    [21] 甘建红,席达,于豪冰,等. 中国南海隋氏蒂壳海绵Theonella swinhoei的化学成分研究[J]. 天然产物研究与开发,2014, (2):209-211.
  • [1] 毛智毅, 王筱燕, 陈晓颖, 汤逸斐.  度拉糖肽联合二甲双胍对肥胖型2型糖尿病患者机体代谢、体脂成分及血清脂肪因子的影响 . 药学实践与服务, 2024, 42(7): 305-309. doi: 10.12206/j.issn.2097-2024.202305032
    [2] 陈方剑, 骆锦前, 王志君, 胡叶帅, 孙煜昕, 宋洪杰.  HPLC-MS/MS同时测定感冒安颗粒中5种黄酮成分的含量 . 药学实践与服务, 2024, 42(9): 402-406. doi: 10.12206/j.issn.2097-2024.202403030
    [3] 李丹, 戴贤春, 王芳珍, 陈奕含, 杨萍, 刘继勇.  HPLC-MS/MS测定当归六黄汤中4种不同成分的含量 . 药学实践与服务, 2024, 42(6): 248-252, 266. doi: 10.12206/j.issn.2097-2024.202305007
  • 加载中
计量
  • 文章访问数:  3581
  • HTML全文浏览量:  310
  • PDF下载量:  989
  • 被引次数: 0
出版历程
  • 收稿日期:  2017-04-06
  • 修回日期:  2017-09-12

西沙群岛隋氏蒂壳海绵Theonella swinhoei的化学成分研究

doi: 10.3969/j.issn.1006-0111.2018.01.011
    基金项目:  国家自然科学基金项目(U1605221,41476121,81602981)

摘要: 目的 对采自西沙群岛的隋氏蒂壳海绵(Theonella swinhoei)的次生代谢产物进行研究。 方法 运用溶剂分步萃取以及减压柱色谱、中压柱色谱、薄层色谱、Sephadex LH-20凝胶柱色谱、高效液相色谱及液质联用等多种色谱分离与分析手段,对隋氏蒂壳海绵的石油醚和二氯甲烷萃取部位进行分离纯化,通过化合物的理化性质及波谱数据,结合文献进行结构鉴定。 结果 共分离得到8个化合物,分别鉴定为cholest-7-ene-3β,5α,6β-triol( 1 ),ergosta-7,22-diene-3β,5α,6β-triol( 2 ),25-norcycloartane-3β,6α,16β,24-tetraol( 3 ),sinuflexibilin D( 4 ),14-deoxycrassin( 5 ),N-(2-phenylethyl)-(9Z)-tetradecanamide( 6 ),N-(2-phenylethyl)-tetradecanamide( 7 ),7,8-dimethyl-isoalloxazine( 8 )。 结论 化合物 1 ~ 7 首次从Theonella属海绵中分离得到。

English Abstract

李彦赟, 徐彬, 程春伟, 林厚文, 杨帆. 西沙群岛隋氏蒂壳海绵Theonella swinhoei的化学成分研究[J]. 药学实践与服务, 2018, 36(1): 55-60. doi: 10.3969/j.issn.1006-0111.2018.01.011
引用本文: 李彦赟, 徐彬, 程春伟, 林厚文, 杨帆. 西沙群岛隋氏蒂壳海绵Theonella swinhoei的化学成分研究[J]. 药学实践与服务, 2018, 36(1): 55-60. doi: 10.3969/j.issn.1006-0111.2018.01.011
LI Yanyun, XU Bin, CHENG Chunwei, LIN Houwen, YANG Fan. Chemical constituents from the marine sponge Theonella swinhoei[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 55-60. doi: 10.3969/j.issn.1006-0111.2018.01.011
Citation: LI Yanyun, XU Bin, CHENG Chunwei, LIN Houwen, YANG Fan. Chemical constituents from the marine sponge Theonella swinhoei[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 55-60. doi: 10.3969/j.issn.1006-0111.2018.01.011
参考文献 (21)

目录

    /

    返回文章
    返回