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应中央军委要求,2022年9月起,《药学实践杂志》将更名为《药学实践与服务》,双月刊,正文96页;2023年1月起,拟出版月刊,正文64页,数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿!

靶向肿瘤微环境的紫杉醇前药研究进展

程丹 许幼发 傅志勤 陈建明

程丹, 许幼发, 傅志勤, 陈建明. 靶向肿瘤微环境的紫杉醇前药研究进展[J]. 药学实践与服务, 2018, 36(1): 1-8. doi: 10.3969/j.issn.1006-0111.2018.01.001
引用本文: 程丹, 许幼发, 傅志勤, 陈建明. 靶向肿瘤微环境的紫杉醇前药研究进展[J]. 药学实践与服务, 2018, 36(1): 1-8. doi: 10.3969/j.issn.1006-0111.2018.01.001
CHENG Dan, XU Youfa, FU Zhiqin, CHEN Jianming. Research progress on tumor-targeting paclitaxel prodrugs[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 1-8. doi: 10.3969/j.issn.1006-0111.2018.01.001
Citation: CHENG Dan, XU Youfa, FU Zhiqin, CHEN Jianming. Research progress on tumor-targeting paclitaxel prodrugs[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 1-8. doi: 10.3969/j.issn.1006-0111.2018.01.001

靶向肿瘤微环境的紫杉醇前药研究进展

doi: 10.3969/j.issn.1006-0111.2018.01.001

Research progress on tumor-targeting paclitaxel prodrugs

  • 摘要: 紫杉醇前药(paclitaxel prodrugs)的设计是一种提高药物制剂成药性、降低其毒副作用、增强抗肿瘤效果的有效手段。随着对前药研究的深入,利用肿瘤过表达的受体、酶、转运蛋白、谷胱甘肽及活性氧自由基以及肿瘤组织弱酸性及低氧环境等作为靶标进行的紫杉醇靶向性前药的研究已取得极大进展。综述近年来以肿瘤微环境特殊的病理与生理特征为靶标的紫杉醇前药的研究进展。
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  • 收稿日期:  2017-09-13
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靶向肿瘤微环境的紫杉醇前药研究进展

doi: 10.3969/j.issn.1006-0111.2018.01.001

摘要: 紫杉醇前药(paclitaxel prodrugs)的设计是一种提高药物制剂成药性、降低其毒副作用、增强抗肿瘤效果的有效手段。随着对前药研究的深入,利用肿瘤过表达的受体、酶、转运蛋白、谷胱甘肽及活性氧自由基以及肿瘤组织弱酸性及低氧环境等作为靶标进行的紫杉醇靶向性前药的研究已取得极大进展。综述近年来以肿瘤微环境特殊的病理与生理特征为靶标的紫杉醇前药的研究进展。

English Abstract

程丹, 许幼发, 傅志勤, 陈建明. 靶向肿瘤微环境的紫杉醇前药研究进展[J]. 药学实践与服务, 2018, 36(1): 1-8. doi: 10.3969/j.issn.1006-0111.2018.01.001
引用本文: 程丹, 许幼发, 傅志勤, 陈建明. 靶向肿瘤微环境的紫杉醇前药研究进展[J]. 药学实践与服务, 2018, 36(1): 1-8. doi: 10.3969/j.issn.1006-0111.2018.01.001
CHENG Dan, XU Youfa, FU Zhiqin, CHEN Jianming. Research progress on tumor-targeting paclitaxel prodrugs[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 1-8. doi: 10.3969/j.issn.1006-0111.2018.01.001
Citation: CHENG Dan, XU Youfa, FU Zhiqin, CHEN Jianming. Research progress on tumor-targeting paclitaxel prodrugs[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 1-8. doi: 10.3969/j.issn.1006-0111.2018.01.001
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