留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

应中央军委要求,2022年9月起,《药学实践杂志》将更名为《药学实践与服务》,双月刊,正文96页;2023年1月起,拟出版月刊,正文64页,数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿!

中国西沙群岛沐浴海绵的化学成分研究

田园 徐彬 王景凤 林厚文 杨连娟 杨帆

田园, 徐彬, 王景凤, 林厚文, 杨连娟, 杨帆. 中国西沙群岛沐浴海绵的化学成分研究[J]. 药学实践与服务, 2017, 35(4): 315-320,382. doi: 10.3969/j.issn.1006-0111.2017.04.007
引用本文: 田园, 徐彬, 王景凤, 林厚文, 杨连娟, 杨帆. 中国西沙群岛沐浴海绵的化学成分研究[J]. 药学实践与服务, 2017, 35(4): 315-320,382. doi: 10.3969/j.issn.1006-0111.2017.04.007
TIAN Yuan, XU Bin, WANG Jingfeng, LIN Houwen, YANG Lianjuan, YANG Fan. Chemical constituents from Spongia sp., a marine sponge in Xisha Islands[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 315-320,382. doi: 10.3969/j.issn.1006-0111.2017.04.007
Citation: TIAN Yuan, XU Bin, WANG Jingfeng, LIN Houwen, YANG Lianjuan, YANG Fan. Chemical constituents from Spongia sp., a marine sponge in Xisha Islands[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 315-320,382. doi: 10.3969/j.issn.1006-0111.2017.04.007

中国西沙群岛沐浴海绵的化学成分研究

doi: 10.3969/j.issn.1006-0111.2017.04.007
基金项目: 北京医学奖励基金(YJHYXKYJJ-125);上海市科委科技支撑项目(15431900900)

Chemical constituents from Spongia sp., a marine sponge in Xisha Islands

  • 摘要: 目的 研究中国西沙群岛沐浴海绵Spongia sp.的化学成分。 方法 运用正相硅胶柱色谱、反相ODS柱色谱、Sephadex LH-20凝胶柱色谱以及半制备高效液相色谱等多种色谱学分离手段,对沐浴海绵Spongia sp.的石油醚萃取层进行分离纯化;通过理化性质、波谱学数据并结合文献报道鉴定化合物的结构,采用微量稀释法评价化合物的体外抗真菌活性。 结果 从海绵Spongia sp.中分离并鉴定了9个化合物,分别为smenodiol( 1 )、smenospongorine( 2 )、5-epi-smenospongorine( 3 )、dictyoceratin C( 4 )、epi-smenospongidine( 5 )、 dictyoceratin A( 6 )、stigmasta-4,6,8(14 ),22-tetraen-3-one( 7 )、3-oxo-4,6,8(14 )-triunsaturated steroid( 8 )、ergosta-4,6,8(14 ),22-tetraen-3-one( 9 )。 结论 化合物 1 ~ 9 均为首次从该属海绵中分离得到,体外抗真菌活性测试显示,化合物 2359 对3种受试菌株(白色念珠菌、须癣毛癣菌和红色毛癣菌)表现出程度不等的抑制活性,MIC值范围在12.5~25 μg/ml。
  • [1] Rueda A,Zubía E,Ortega MJ,et al.New metabolites from the sponge Spongia agaricina[J].J Nat Prod,1998,61(2):258-261.
    [2] Li CJ,Schmitz FJ,Kelly-Borges M.Six new spongian diterpenes from the sponge spongia matamat [J].J Nat Prod,1999,62(2):287-290.
    [3] Garrido L,Zubía E,Ortega MJ,et al.New furanoterpenoids from the sponge spongia officinalis[J].J Nat Prod,1997,60(8):794-797.
    [4] Guella G,Mancini I,Chiasera G,et al.Rogiolol acetate: A novel β-chamigrene-type sesquiterpeneisolated from a marine sponge[J].Helv Chim Acta,1990,73(6):1612-1620.
    [5] Utkina NK,Denisenko VA,Scholokova OV,et al.Cyclosmenospongine,a new sesquiterpenoid aminoquinone from an Australian marine sponge spongia sp.[J].Tetrahedron Lett,2003,44(1):101-102.
    [6] Sunassee SN,Davies-Coleman MT.Cytotoxic and antioxidant marine prenylated quinones and hydroquinones[J].Nat Prod Rep,2012,29(5):513-535.
    [7] Sladic D,Gasic MJ.Reactivity and biological activity of the marine sesquiterpene hydroquinone avarol and related compounds from sponges of the order dictyoceratida[J].Molecules,2006,11(1):1-33.
    [8] Yamakawa Y,Kato T,Ito J,et al.Identification of growth-promoting factors from various glioma cell lines and partial purification of the factor from C6 solid tumor[J].Neurochem Int,2014,4(5):367-373.
    [9] Qiu Y,Wang XM.A new sesquiterpenoid hydroquinone from the marine sponge Dysidea arenaria[J].Molecules,2008,13(6):1275-1281.
    [10] Nguyen HM,Ito T,Win NN,et al.New antibacterial sesquiterpene aminoquinones from a Vietnamese marine sponge of Spongia sp.[J].Phytochem Lett,2016,17(3):288-292.
    [11] Kondracki ML,Guyot M.Biologically active quinone and hydroquinone sesquiterpenoids from the sponge Smenospongia sp.[J].Tetrahedron,1989,45(7):1995-2004.
    [12] Zhang Y,Li Y,Guo YW,et al.A sesquiterpene quinone,dysidine,from the sponge Dysidea villosa,activates the insulin pathway through inhibition of PTPases[J].Acta Pharmacol Sin,2009,30(3):333-345.
    [13] Liu H,Wang G,Namikoshi M,et al.Sesquiterpene quinones from a marine sponge Hippospongia sp.that inhibit maturation of starfish oocytes and induce cell cycle arrest with HepG2 cells[J].Pharm Biol,2006,44(7):522-527.
    [14] Laube T,Bernet A,Dahse HM,et al.Synthesis and pharmacological activities of some sesquiterpene quinones and hydroquinones[J].Bioorg Med Chem,2009,17(4):1422-1427.
    [15] Bernet A,Schr der J,Seifert K.Total synthesis of the marine sesquiterpene quinones hyatellaquinone and spongiaquinone[J].Helv Chim Acta,2003,86(6):2009-2020.
    [16] Marcos IS,Conde A,Moro RF,et al.Synthesis of quinone/hydroquinone sesquiterpenes[J].Tetrahedron,2010,66(42):8280-8290.
    [17] Venkateswarlu Y,Faulkner DJ,Steiner JLR,et al.Smenochromenes,unusual macrocyclic sesquiterpene hydroquinone derivatives from a Seychelles sponge of the genus Smenospongia[J].J Org Chem,1991,56(22):6271-6274.
    [18] Kondracki ML,Guyot M.Smenospongine: acytotoxic and antimicrobial aminoquinone isolated from smenospongia sp.[J].Tetrahedron Lett,28(47):5815-5818.
    [19] Aoki S,Kong D,Matsui K,et al.Sesquiterpene aminoquinones,from a marine sponge,induce erythroid differentiation in human chronic myelogenous leukemia,K562 cells[J].Chem Pharm Bull,2004,52(8):935-937.
    [20] Mitome H,Nagasawa T,Miyaoka H,et al.Dactyloquinones C,D and E novel sesquiterpenoid quinones,from the Okinawan marine sponge,Dactylospongia elegans[J].J Nat Prod,2002,58(9):1693-1696.
    [21] Rodriguez J,Quinoa E,Riguera R,et al. The structures and stereochemistry of cytotoxic sesquiterpene quinones from dactylospongia elegans[J].Tetrahedron,1992,48(32):6667-6680.
    [22] Ibrahim SRM, Elkhayat ES, Mohamed GA,et al.Aspernolides F and G,new butyrolactones from the endophytic fungus Aspergillus terreus[J].Phytochem Lett,2015,14(4):84-90.
    [23] Kobayashi M,Krishna MM,Ishida K,et al.Marine sterols.XXⅡ.occurrence of 3-oxo-4,6,8(14)-triunsaturated steroids in the sponge dysidea herbacea[J].Chem Pharm Bull,1992,40(1):72-74.
    [24] Fujimoto H, Nakamura E, Okuyama E,et al.Six immunosuppressive features from an ascomycete,Zopfiella longicaudata,found in a screening study monitored by immunomodulatory activity[J].Chem Pharm Bull,2004,52(8):1005-1008.
    [25] Pierce CG,Uppuluri P,Tristan AR,et al.A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing[J].Nat Protoc,2008,3(9):1494-1500.
    [26] Espinel-Ingroff A,Fothergill A,Fuller J,et al.Wild-type MIC distributions and epidemiological cutoff values for caspofungin and Aspergillus spp.for the CLSI broth microdilution method(M38-A2 document)[J].Antimicrob Agents Chemother,2011,55(6):2855-2859.
  • [1] 毛智毅, 王筱燕, 陈晓颖, 汤逸斐.  度拉糖肽联合二甲双胍对肥胖型2型糖尿病患者机体代谢、体脂成分及血清脂肪因子的影响 . 药学实践与服务, 2024, 42(7): 305-309. doi: 10.12206/j.issn.2097-2024.202305032
    [2] 李丹, 戴贤春, 王芳珍, 陈奕含, 杨萍, 刘继勇.  HPLC-MS/MS测定当归六黄汤中4种不同成分的含量 . 药学实践与服务, 2024, 42(6): 248-252, 266. doi: 10.12206/j.issn.2097-2024.202305007
    [3] 赖立勇, 夏天爽, 徐圣焱, 蒋益萍, 岳小强, 辛海量.  中药青蒿抗氧化活性的谱效关系研究 . 药学实践与服务, 2024, 42(5): 203-210, 216. doi: 10.12206/j.issn.2097-2024.202211012
  • 加载中
计量
  • 文章访问数:  3330
  • HTML全文浏览量:  292
  • PDF下载量:  1098
  • 被引次数: 0
出版历程
  • 收稿日期:  2017-01-17
  • 修回日期:  2017-04-14

中国西沙群岛沐浴海绵的化学成分研究

doi: 10.3969/j.issn.1006-0111.2017.04.007
    基金项目:  北京医学奖励基金(YJHYXKYJJ-125);上海市科委科技支撑项目(15431900900)

摘要: 目的 研究中国西沙群岛沐浴海绵Spongia sp.的化学成分。 方法 运用正相硅胶柱色谱、反相ODS柱色谱、Sephadex LH-20凝胶柱色谱以及半制备高效液相色谱等多种色谱学分离手段,对沐浴海绵Spongia sp.的石油醚萃取层进行分离纯化;通过理化性质、波谱学数据并结合文献报道鉴定化合物的结构,采用微量稀释法评价化合物的体外抗真菌活性。 结果 从海绵Spongia sp.中分离并鉴定了9个化合物,分别为smenodiol( 1 )、smenospongorine( 2 )、5-epi-smenospongorine( 3 )、dictyoceratin C( 4 )、epi-smenospongidine( 5 )、 dictyoceratin A( 6 )、stigmasta-4,6,8(14 ),22-tetraen-3-one( 7 )、3-oxo-4,6,8(14 )-triunsaturated steroid( 8 )、ergosta-4,6,8(14 ),22-tetraen-3-one( 9 )。 结论 化合物 1 ~ 9 均为首次从该属海绵中分离得到,体外抗真菌活性测试显示,化合物 2359 对3种受试菌株(白色念珠菌、须癣毛癣菌和红色毛癣菌)表现出程度不等的抑制活性,MIC值范围在12.5~25 μg/ml。

English Abstract

田园, 徐彬, 王景凤, 林厚文, 杨连娟, 杨帆. 中国西沙群岛沐浴海绵的化学成分研究[J]. 药学实践与服务, 2017, 35(4): 315-320,382. doi: 10.3969/j.issn.1006-0111.2017.04.007
引用本文: 田园, 徐彬, 王景凤, 林厚文, 杨连娟, 杨帆. 中国西沙群岛沐浴海绵的化学成分研究[J]. 药学实践与服务, 2017, 35(4): 315-320,382. doi: 10.3969/j.issn.1006-0111.2017.04.007
TIAN Yuan, XU Bin, WANG Jingfeng, LIN Houwen, YANG Lianjuan, YANG Fan. Chemical constituents from Spongia sp., a marine sponge in Xisha Islands[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 315-320,382. doi: 10.3969/j.issn.1006-0111.2017.04.007
Citation: TIAN Yuan, XU Bin, WANG Jingfeng, LIN Houwen, YANG Lianjuan, YANG Fan. Chemical constituents from Spongia sp., a marine sponge in Xisha Islands[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 315-320,382. doi: 10.3969/j.issn.1006-0111.2017.04.007
参考文献 (26)

目录

    /

    返回文章
    返回