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肿瘤坏死因子及其受体在类风湿性关节炎中的研究进展

王洁 卞莹莹 张川 开国银 陆一鸣

王洁, 卞莹莹, 张川, 开国银, 陆一鸣. 肿瘤坏死因子及其受体在类风湿性关节炎中的研究进展[J]. 药学实践与服务, 2017, 35(4): 289-293. doi: 10.3969/j.issn.1006-0111.2017.04.001
引用本文: 王洁, 卞莹莹, 张川, 开国银, 陆一鸣. 肿瘤坏死因子及其受体在类风湿性关节炎中的研究进展[J]. 药学实践与服务, 2017, 35(4): 289-293. doi: 10.3969/j.issn.1006-0111.2017.04.001
WANG Jie, BIAN Yingying, ZHANG Chuan, KAI Guoyin, LU Yiming. Research progress of TNF-α and its receptors in rheumatoid arthritis[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 289-293. doi: 10.3969/j.issn.1006-0111.2017.04.001
Citation: WANG Jie, BIAN Yingying, ZHANG Chuan, KAI Guoyin, LU Yiming. Research progress of TNF-α and its receptors in rheumatoid arthritis[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 289-293. doi: 10.3969/j.issn.1006-0111.2017.04.001

肿瘤坏死因子及其受体在类风湿性关节炎中的研究进展

doi: 10.3969/j.issn.1006-0111.2017.04.001
基金项目: 国家自然科学基金资助项目(30500093,81274162);国家科技部"重大新药创制"专项(2009ZX09103-690);上海市科委生物医药领域科技支撑项目(16431904400);上海市教委科研创新项目(14ZZ077)

Research progress of TNF-α and its receptors in rheumatoid arthritis

  • 摘要: 肿瘤坏死因子α(TNF-α)信号通路是治疗自身免疫性疾病的重要靶点。TNF-α能够结合到2个不同的受体上,通过与受体的结合发挥抗炎、抗风湿的作用。抗TNF-α的药物被广泛应用于类风湿性关节炎(RA)的治疗,如英夫利昔单抗、阿达木单抗等。其在抑制炎症引起的损伤及受损组织的恢复等方面具有重要作用,但是也会引起一定的副作用,如增加感染和恶性肿瘤的风险、引起新的自身免疫性疾病等。这些副作用可能是由于封闭了TNF-α的有益信号引起的,而选择性拮抗肿瘤坏死因子受体(tumor necrosis factor receptor,TNFR)可能是解决TNF-α抗体副作用的一个重要途径,特异性地作用于TNFR的药物具有更加广阔的实用性和安全性。针对TNF-α及其受体的药物在RA中的研究进展进行综述。
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  • 收稿日期:  2017-05-31
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肿瘤坏死因子及其受体在类风湿性关节炎中的研究进展

doi: 10.3969/j.issn.1006-0111.2017.04.001
    基金项目:  国家自然科学基金资助项目(30500093,81274162);国家科技部"重大新药创制"专项(2009ZX09103-690);上海市科委生物医药领域科技支撑项目(16431904400);上海市教委科研创新项目(14ZZ077)

摘要: 肿瘤坏死因子α(TNF-α)信号通路是治疗自身免疫性疾病的重要靶点。TNF-α能够结合到2个不同的受体上,通过与受体的结合发挥抗炎、抗风湿的作用。抗TNF-α的药物被广泛应用于类风湿性关节炎(RA)的治疗,如英夫利昔单抗、阿达木单抗等。其在抑制炎症引起的损伤及受损组织的恢复等方面具有重要作用,但是也会引起一定的副作用,如增加感染和恶性肿瘤的风险、引起新的自身免疫性疾病等。这些副作用可能是由于封闭了TNF-α的有益信号引起的,而选择性拮抗肿瘤坏死因子受体(tumor necrosis factor receptor,TNFR)可能是解决TNF-α抗体副作用的一个重要途径,特异性地作用于TNFR的药物具有更加广阔的实用性和安全性。针对TNF-α及其受体的药物在RA中的研究进展进行综述。

English Abstract

王洁, 卞莹莹, 张川, 开国银, 陆一鸣. 肿瘤坏死因子及其受体在类风湿性关节炎中的研究进展[J]. 药学实践与服务, 2017, 35(4): 289-293. doi: 10.3969/j.issn.1006-0111.2017.04.001
引用本文: 王洁, 卞莹莹, 张川, 开国银, 陆一鸣. 肿瘤坏死因子及其受体在类风湿性关节炎中的研究进展[J]. 药学实践与服务, 2017, 35(4): 289-293. doi: 10.3969/j.issn.1006-0111.2017.04.001
WANG Jie, BIAN Yingying, ZHANG Chuan, KAI Guoyin, LU Yiming. Research progress of TNF-α and its receptors in rheumatoid arthritis[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 289-293. doi: 10.3969/j.issn.1006-0111.2017.04.001
Citation: WANG Jie, BIAN Yingying, ZHANG Chuan, KAI Guoyin, LU Yiming. Research progress of TNF-α and its receptors in rheumatoid arthritis[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 289-293. doi: 10.3969/j.issn.1006-0111.2017.04.001
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